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Angiomodulators in cancer therapy: New perspectives
L. Varinska, P. Kubatka, J. Mojzis, A. Zulli, K. Gazdikova, P. Zubor, D. Büsselberg, M. Caprnda, R. Opatrilova, I. Gasparova, M. Klabusay, M. Pec, E. Fibach, M. Adamek, P. Kruzliak,
Jazyk angličtina Země Francie
Typ dokumentu časopisecké články, přehledy
- MeSH
- antitumorózní látky farmakologie MeSH
- biologické přípravky farmakologie MeSH
- galektiny účinky léků MeSH
- inhibitory angiogeneze farmakologie MeSH
- látky modulující angiogenezi farmakologie MeSH
- lidé MeSH
- mikro RNA účinky léků MeSH
- mořské toxiny farmakologie MeSH
- nádory farmakoterapie MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
The formation of new blood vessels plays a crucial for the development and progression of pathophysiological changes associated with a variety of disorders, including carcinogenesis. Angiogenesis inhibitors (anti-angiogenics) are an important part of treatment for some types of cancer. Some natural products isolated from marine invertebrates have revealed antiangiogenic activities, which are diverse in structure and mechanisms of action. Many preclinical studies have generated new models for further modification and optimization of anti-angiogenic substances, and new information for mechanistic studies and new anti-cancer drug candidates for clinical practice. Moreover, in the last decade it has become apparent that galectins are important regulators of tumor angiogenesis, as well as microRNA. MicroRNAs have been validated to modulate endothelial cell migration or endothelial tube organization. In the present review we summarize the current knowledge regarding the role of marine-derived natural products, galectins and microRNAs in tumor angiogenesis.
2nd Department of Internal Medicine Faculty of Medicine Comenius University Bratislava Slovakia
Department of Hematology Hadassah Hebrew University Medical Center Jerusalem Israel
Department of Pharmacology Faculty of Medicine Pavol Jozef Safarik University Kosice Slovakia
Weill Cornell Medicine in Qatar Qatar Foundation Education City Doha Qatar
Citace poskytuje Crossref.org
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- $a Varinska, Lenka $u Department of Pharmacology, Faculty of Medicine, Pavol Jozef Safarik University, Kosice, Slovakia.
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- $a The formation of new blood vessels plays a crucial for the development and progression of pathophysiological changes associated with a variety of disorders, including carcinogenesis. Angiogenesis inhibitors (anti-angiogenics) are an important part of treatment for some types of cancer. Some natural products isolated from marine invertebrates have revealed antiangiogenic activities, which are diverse in structure and mechanisms of action. Many preclinical studies have generated new models for further modification and optimization of anti-angiogenic substances, and new information for mechanistic studies and new anti-cancer drug candidates for clinical practice. Moreover, in the last decade it has become apparent that galectins are important regulators of tumor angiogenesis, as well as microRNA. MicroRNAs have been validated to modulate endothelial cell migration or endothelial tube organization. In the present review we summarize the current knowledge regarding the role of marine-derived natural products, galectins and microRNAs in tumor angiogenesis.
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- $a Kubatka, Peter $u Department of Medical Biology, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin, Slovakia; Division of Oncology, Biomedical Center Martin, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin, Slovakia. Electronic address: kubatka@jfmed.uniba.sk.
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