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Do human B-lymphocytes avoid aging until 60 years

A. Knight, P. Nemec, S. Bretzova, L. Valkova, M. Kolmanova, R. Vytopilova, M. Havelka, P. Vsianska, L. Rihova, M. Krejci, M. Piskacek,

. 2016 ; 7 (28) : 42873-42880.

Language English Country United States

Document type Journal Article

Persistent link   https://www.medvik.cz/link/bmc18011144

Grant support
NT14310 MZ0 CEP Register
NV15-32935A MZ0 CEP Register

Broad changes in human innate and adaptive immunity are associated with advanced age. The age-related alteration of gene expression was reported for both T and B lymphocytes. We analysed the genome-wide expression profiles (n=20) of naive and whole B cell populations from young and early aged healthy donors under 60 years. We revealed large homogeneity of all analysed genome-wide expression profiles but did not identified any significant gene deregulation between young (30-45 years) and early aged healthy donors (50-60 years). We argue that B cells avoid the aging program on molecular level until 60 years of age. Our results demonstrate the potential of hematopoietic stem cells to generate uncompromised lymphocytes in early elderly. These are very encouraging findings for the general health and the immunity maintenance would not need any intervention to naive B cells. Rather, a suitable immune stimulation in healthy body environment warrants further research into aging of older elderly.

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$a Knight, Andrea $u Department of Pathological Physiology, Faculty of Medicine, Masaryk University Brno, Brno, Czech Republic. Gamma-Delta T Cell Laboratory, University Hospital Brno, Brno, Czech Republic.
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$a Broad changes in human innate and adaptive immunity are associated with advanced age. The age-related alteration of gene expression was reported for both T and B lymphocytes. We analysed the genome-wide expression profiles (n=20) of naive and whole B cell populations from young and early aged healthy donors under 60 years. We revealed large homogeneity of all analysed genome-wide expression profiles but did not identified any significant gene deregulation between young (30-45 years) and early aged healthy donors (50-60 years). We argue that B cells avoid the aging program on molecular level until 60 years of age. Our results demonstrate the potential of hematopoietic stem cells to generate uncompromised lymphocytes in early elderly. These are very encouraging findings for the general health and the immunity maintenance would not need any intervention to naive B cells. Rather, a suitable immune stimulation in healthy body environment warrants further research into aging of older elderly.
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$a Nemec, Pavel $u Department of Pathological Physiology, Faculty of Medicine, Masaryk University Brno, Brno, Czech Republic.
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$a Bretzova, Sona $u Department of Pathological Physiology, Faculty of Medicine, Masaryk University Brno, Brno, Czech Republic. Laboratory of Cancer Biology and Genetics, University Hospital Brno, Brno, Czech Republic.
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$a Valkova, Lucie $u Department of Pathological Physiology, Faculty of Medicine, Masaryk University Brno, Brno, Czech Republic. Laboratory of Cancer Biology and Genetics, University Hospital Brno, Brno, Czech Republic.
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$a Vsianska, Pavla $u Department of Clinical Haematology, University Hospital Brno, Brno, Czech Republic.
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