Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

Do human B-lymphocytes avoid aging until 60 years

A. Knight, P. Nemec, S. Bretzova, L. Valkova, M. Kolmanova, R. Vytopilova, M. Havelka, P. Vsianska, L. Rihova, M. Krejci, M. Piskacek,

. 2016 ; 7 (28) : 42873-42880.

Jazyk angličtina Země Spojené státy americké

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc18011144

Grantová podpora
NT14310 MZ0 CEP - Centrální evidence projektů
NV15-32935A MZ0 CEP - Centrální evidence projektů

Broad changes in human innate and adaptive immunity are associated with advanced age. The age-related alteration of gene expression was reported for both T and B lymphocytes. We analysed the genome-wide expression profiles (n=20) of naive and whole B cell populations from young and early aged healthy donors under 60 years. We revealed large homogeneity of all analysed genome-wide expression profiles but did not identified any significant gene deregulation between young (30-45 years) and early aged healthy donors (50-60 years). We argue that B cells avoid the aging program on molecular level until 60 years of age. Our results demonstrate the potential of hematopoietic stem cells to generate uncompromised lymphocytes in early elderly. These are very encouraging findings for the general health and the immunity maintenance would not need any intervention to naive B cells. Rather, a suitable immune stimulation in healthy body environment warrants further research into aging of older elderly.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc18011144
003      
CZ-PrNML
005      
20201111091051.0
007      
ta
008      
180404s2016 xxu f 000 0|eng||
009      
AR
024    7_
$a 10.18632/oncotarget.10146 $2 doi
035    __
$a (PubMed)27344181
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxu
100    1_
$a Knight, Andrea $u Department of Pathological Physiology, Faculty of Medicine, Masaryk University Brno, Brno, Czech Republic. Gamma-Delta T Cell Laboratory, University Hospital Brno, Brno, Czech Republic.
245    10
$a Do human B-lymphocytes avoid aging until 60 years / $c A. Knight, P. Nemec, S. Bretzova, L. Valkova, M. Kolmanova, R. Vytopilova, M. Havelka, P. Vsianska, L. Rihova, M. Krejci, M. Piskacek,
520    9_
$a Broad changes in human innate and adaptive immunity are associated with advanced age. The age-related alteration of gene expression was reported for both T and B lymphocytes. We analysed the genome-wide expression profiles (n=20) of naive and whole B cell populations from young and early aged healthy donors under 60 years. We revealed large homogeneity of all analysed genome-wide expression profiles but did not identified any significant gene deregulation between young (30-45 years) and early aged healthy donors (50-60 years). We argue that B cells avoid the aging program on molecular level until 60 years of age. Our results demonstrate the potential of hematopoietic stem cells to generate uncompromised lymphocytes in early elderly. These are very encouraging findings for the general health and the immunity maintenance would not need any intervention to naive B cells. Rather, a suitable immune stimulation in healthy body environment warrants further research into aging of older elderly.
650    _2
$a adaptivní imunita $x genetika $x imunologie $7 D056704
650    _2
$a dospělí $7 D000328
650    _2
$a stárnutí $x genetika $x imunologie $7 D000375
650    _2
$a B-lymfocyty $x imunologie $x metabolismus $7 D001402
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a stanovení celkové genové exprese $x metody $7 D020869
650    _2
$a lidé $7 D006801
650    _2
$a přirozená imunita $x genetika $x imunologie $7 D007113
650    _2
$a receptor interleukinu-7 - alfa-podjednotka $x genetika $x imunologie $x metabolismus $7 D053699
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a lidé středního věku $7 D008875
650    _2
$a transkriptom $x genetika $x imunologie $7 D059467
655    _2
$a časopisecké články $7 D016428
700    1_
$a Nemec, Pavel $u Department of Pathological Physiology, Faculty of Medicine, Masaryk University Brno, Brno, Czech Republic.
700    1_
$a Bretzova, Sona $u Department of Pathological Physiology, Faculty of Medicine, Masaryk University Brno, Brno, Czech Republic. Laboratory of Cancer Biology and Genetics, University Hospital Brno, Brno, Czech Republic.
700    1_
$a Valkova, Lucie $u Department of Pathological Physiology, Faculty of Medicine, Masaryk University Brno, Brno, Czech Republic. Laboratory of Cancer Biology and Genetics, University Hospital Brno, Brno, Czech Republic.
700    1_
$a Kolmanová, Markéta $u Department of Pathological Physiology, Faculty of Medicine, Masaryk University Brno, Brno, Czech Republic. Laboratory of Cancer Biology and Genetics, University Hospital Brno, Brno, Czech Republic. $7 xx0213402
700    1_
$a Vytopilova, Renata $u Department of Pathological Physiology, Faculty of Medicine, Masaryk University Brno, Brno, Czech Republic. Laboratory of Cancer Biology and Genetics, University Hospital Brno, Brno, Czech Republic.
700    1_
$a Havelka, Marek $u Department of Pathological Physiology, Faculty of Medicine, Masaryk University Brno, Brno, Czech Republic. Laboratory of Cancer Biology and Genetics, University Hospital Brno, Brno, Czech Republic.
700    1_
$a Vsianska, Pavla $u Department of Clinical Haematology, University Hospital Brno, Brno, Czech Republic.
700    1_
$a Říhová, Lucie $u Department of Clinical Haematology, University Hospital Brno, Brno, Czech Republic. $7 xx0081970
700    1_
$a Krejčí, Marta, $u Department of Internal Medicine, Haematology and Oncology, University Hospital Brno, Brno, Czech Republic. $d 1969- $7 jx20080512017
700    1_
$a Piskáček, Martin $u Department of Pathological Physiology, Faculty of Medicine, Masaryk University Brno, Brno, Czech Republic. Laboratory of Cancer Biology and Genetics, University Hospital Brno, Brno, Czech Republic. $7 xx0213400
773    0_
$w MED00184852 $t Oncotarget $x 1949-2553 $g Roč. 7, č. 28 (2016), s. 42873-42880
856    41
$u https://pubmed.ncbi.nlm.nih.gov/27344181 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20180404 $b ABA008
991    __
$a 20201111091047 $b ABA008
999    __
$a ok $b bmc $g 1288629 $s 1007956
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2016 $b 7 $c 28 $d 42873-42880 $i 1949-2553 $m Oncotarget $n Oncotarget $x MED00184852
GRA    __
$a NT14310 $p MZ0
GRA    __
$a NV15-32935A $p MZ0
LZP    __
$a Pubmed-20180404

Najít záznam

Citační ukazatele

Pouze přihlášení uživatelé

Možnosti archivace