Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

Unique white matter microstructural patterns in ADHD presentations-a diffusion tensor imaging study

A. Svatkova, I. Nestrasil, K. Rudser, J. Goldenring Fine, J. Bledsoe, M. Semrud-Clikeman,

. 2016 ; 37 (9) : 3323-36. [pub] 20160509

Jazyk angličtina Země Spojené státy americké

Typ dokumentu časopisecké články, Research Support, N.I.H., Extramural, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc18011223

Attention-deficit/hyperactivity disorder predominantly inattentive (ADHD-PI) and combined (ADHD-C) presentations are likely distinct disorders that differ neuroanatomically, neurochemically, and neuropsychologically. However, to date, little is known about specific white matter (WM) regions differentiating ADHD presentations. This study examined differences in WM microstructure using diffusion tensor imaging (DTI) data from 20 ADHD-PI, 18 ADHD-C, and 27 typically developed children. Voxel-wise analysis of DTI measurements in major fiber bundles was carried out using tract-based spatial statistics (TBSS). Clusters showing diffusivity abnormalities were used as regions of interest for regression analysis between fractional anisotropy (FA) and neuropsychological outcomes. Compared to neurotypicals, ADHD-PI children showed higher FA in the anterior thalamic radiations (ATR), bilateral inferior longitudinal fasciculus (ILF), and in the left corticospinal tract (CST). In contrast, the ADHD-C group exhibited higher FA in the bilateral cingulum bundle (CB). In the ADHD-PI group, differences in FA in the left ILF and ATR were accompanied by axial diffusivity (AD) abnormalities. In addition, the ADHD-PI group exhibited atypical mean diffusivity in the forceps minor (FMi) and left ATR and AD differences in right CB compared to healthy subjects. Direct comparison between ADHD presentations demonstrated radial diffusivity differences in FMi. WM clusters with FA irregularities in ADHD were associated with neurobehavioral performance across groups. In conclusion, differences in WM microstructure in ADHD presentations strengthen the theory that ADHD-PI and ADHD-C are two distinct disorders. Regions with WM irregularity seen in both ADHD presentations might serve as predictors of executive and behavioral functioning across groups. Hum Brain Mapp 37:3323-3336, 2016. © 2016 Wiley Periodicals, Inc.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc18011223
003      
CZ-PrNML
005      
20180404142642.0
007      
ta
008      
180404s2016 xxu f 000 0|eng||
009      
AR
024    7_
$a 10.1002/hbm.23243 $2 doi
035    __
$a (PubMed)27159198
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxu
100    1_
$a Svatkova, Alena $u Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota. Multimodal and Functional Neuroimaging Research Group, CEITEC-Central European Institute of Technology, Masaryk University, Brno, Czech Republic.
245    10
$a Unique white matter microstructural patterns in ADHD presentations-a diffusion tensor imaging study / $c A. Svatkova, I. Nestrasil, K. Rudser, J. Goldenring Fine, J. Bledsoe, M. Semrud-Clikeman,
520    9_
$a Attention-deficit/hyperactivity disorder predominantly inattentive (ADHD-PI) and combined (ADHD-C) presentations are likely distinct disorders that differ neuroanatomically, neurochemically, and neuropsychologically. However, to date, little is known about specific white matter (WM) regions differentiating ADHD presentations. This study examined differences in WM microstructure using diffusion tensor imaging (DTI) data from 20 ADHD-PI, 18 ADHD-C, and 27 typically developed children. Voxel-wise analysis of DTI measurements in major fiber bundles was carried out using tract-based spatial statistics (TBSS). Clusters showing diffusivity abnormalities were used as regions of interest for regression analysis between fractional anisotropy (FA) and neuropsychological outcomes. Compared to neurotypicals, ADHD-PI children showed higher FA in the anterior thalamic radiations (ATR), bilateral inferior longitudinal fasciculus (ILF), and in the left corticospinal tract (CST). In contrast, the ADHD-C group exhibited higher FA in the bilateral cingulum bundle (CB). In the ADHD-PI group, differences in FA in the left ILF and ATR were accompanied by axial diffusivity (AD) abnormalities. In addition, the ADHD-PI group exhibited atypical mean diffusivity in the forceps minor (FMi) and left ATR and AD differences in right CB compared to healthy subjects. Direct comparison between ADHD presentations demonstrated radial diffusivity differences in FMi. WM clusters with FA irregularities in ADHD were associated with neurobehavioral performance across groups. In conclusion, differences in WM microstructure in ADHD presentations strengthen the theory that ADHD-PI and ADHD-C are two distinct disorders. Regions with WM irregularity seen in both ADHD presentations might serve as predictors of executive and behavioral functioning across groups. Hum Brain Mapp 37:3323-3336, 2016. © 2016 Wiley Periodicals, Inc.
650    _2
$a hyperkinetická porucha $x patologie $7 D001289
650    _2
$a mozek $x patologie $7 D001921
650    _2
$a mapování mozku $7 D001931
650    _2
$a dítě $7 D002648
650    _2
$a zobrazování difuzních tenzorů $7 D056324
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a lidé $7 D006801
650    _2
$a interpretace obrazu počítačem $7 D007090
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a nervové dráhy $x patologie $7 D009434
650    _2
$a neuropsychologické testy $7 D009483
650    _2
$a bílá hmota $x patologie $7 D066127
655    _2
$a časopisecké články $7 D016428
655    _2
$a Research Support, N.I.H., Extramural $7 D052061
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Nestrasil, Igor $u Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota.
700    1_
$a Rudser, Kyle $u Division of Biostatistics, University of Minnesota, Minneapolis, Minnesota.
700    1_
$a Goldenring Fine, Jodene $u Department of Counseling, Educational Psychology, and Special Education, Michigan State University, East Lansing, Michigan.
700    1_
$a Bledsoe, Jesse $u Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, Washington.
700    1_
$a Semrud-Clikeman, Margaret $u Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota.
773    0_
$w MED00002066 $t Human brain mapping $x 1097-0193 $g Roč. 37, č. 9 (2016), s. 3323-36
856    41
$u https://pubmed.ncbi.nlm.nih.gov/27159198 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20180404 $b ABA008
991    __
$a 20180404142722 $b ABA008
999    __
$a ok $b bmc $g 1288708 $s 1008035
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2016 $b 37 $c 9 $d 3323-36 $e 20160509 $i 1097-0193 $m Human brain mapping $n Hum Brain Mapp $x MED00002066
LZP    __
$a Pubmed-20180404

Najít záznam

Citační ukazatele

Možnosti archivace