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The EuroMyositis registry: an international collaborative tool to facilitate myositis research
JB. Lilleker, J. Vencovsky, G. Wang, LR. Wedderburn, LP. Diederichsen, J. Schmidt, P. Oakley, O. Benveniste, MG. Danieli, K. Danko, NTP. Thuy, M. Vazquez-Del Mercado, H. Andersson, B. De Paepe, JL. deBleecker, B. Maurer, LJ. McCann, N. Pipitone,...
Jazyk angličtina Země Velká Británie
Typ dokumentu časopisecké články, multicentrická studie
NLK
ProQuest Central
od 1939-01-01 do Před 6 měsíci
Health & Medicine (ProQuest)
od 1939-01-01 do Před 6 měsíci
Family Health Database (ProQuest)
od 1939-01-01 do Před 6 měsíci
ROAD: Directory of Open Access Scholarly Resources
- MeSH
- biomedicínský výzkum metody MeSH
- kohortové studie MeSH
- kouření škodlivé účinky MeSH
- lidé MeSH
- mezinárodní spolupráce * MeSH
- myozitida epidemiologie etiologie patologie MeSH
- prognóza MeSH
- průřezové studie MeSH
- průzkumy a dotazníky MeSH
- registrace statistika a číselné údaje MeSH
- stupeň závažnosti nemoci MeSH
- zdravotní stav MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- multicentrická studie MeSH
AIMS: The EuroMyositis Registry facilitates collaboration across the idiopathic inflammatory myopathy (IIM) research community. This inaugural report examines pooled Registry data. METHODS: Cross-sectional analysis of IIM cases from 11 countries was performed. Associations between clinical subtypes, extramuscular involvement, environmental exposures and medications were investigated. RESULTS: Of 3067 IIM cases, 69% were female. The most common IIM subtype was dermatomyositis (DM) (31%). Smoking was more frequent in connective tissue disease overlap cases (45%, OR 1.44, 95% CI 1.09 to 1.90, p=0.012). Smoking was associated with interstitial lung disease (ILD) (OR 1.32, 95% CI 1.06 to 1.65, p=0.013), dysphagia (OR 1.43, 95% CI 1.16 to 1.77, p=0.001), malignancy ever (OR 1.78, 95% CI 1.36 to 2.33, p<0.001) and cardiac involvement (OR 2.40, 95% CI 1.60 to 3.60, p<0.001).Dysphagia occurred in 39% and cardiac involvement in 9%; either occurrence was associated with higher Health Assessment Questionnaire (HAQ) scores (adjusted OR 1.79, 95% CI 1.43 to 2.23, p<0.001). HAQ scores were also higher in inclusion body myositis cases (adjusted OR 3.85, 95% CI 2.52 to 5.90, p<0.001). Malignancy (ever) occurred in 13%, most commonly in DM (20%, OR 2.06, 95% CI 1.65 to 2.57, p<0.001).ILD occurred in 30%, most frequently in antisynthetase syndrome (71%, OR 10.7, 95% CI 8.6 to 13.4, p<0.001). Rash characteristics differed between adult-onset and juvenile-onset DM cases ('V' sign: 56% DM vs 16% juvenile-DM, OR 0.16, 95% CI 0.07 to 0.36, p<0.001). Glucocorticoids were used in 98% of cases, methotrexate in 71% and azathioprine in 51%. CONCLUSION: This large multicentre cohort demonstrates the importance of extramuscular involvement in patients with IIM, its association with smoking and its influence on disease severity. Our findings emphasise that IIM is a multisystem inflammatory disease and will help inform prognosis and clinical management of patients.
Department of Neurology Ghent University Hospital Ghent Belgium
Department of Neurology University Medical Center Göttingen Göttingen Germany
Department of Rheumatology Alder Hey Children's NHS Foundation Trust Liverpool UK
Department of Rheumatology Arcispedale S Maria Nuova IRCCS of Reggio Emilia Reggio Emilia Italy
Department of Rheumatology China Japan Friendship Hospital Beijing China
Department of Rheumatology Odense University Hospital Odense Denmark
Department of Rheumatology Oslo University Hospital Oslo Norway
Department of Rheumatology University Hospital Zurich Zurich Switzerland
División de Medicina Interna Universidad de Guadalajara Guadalajara Jalisco Mexico
Division of Immunology University of Debrecen Debrecen Hungary
Institute of Rheumatology Prague Czech Republic
MRC ARUK Institute of Ageing and Chronic Disease University of Liverpool Liverpool UK
Citace poskytuje Crossref.org
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- $a Lilleker, James B $u Division of Musculoskeletal and Dermatological Sciences, Centre for Musculoskeletal Research, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK. Greater Manchester Neurosciences Centre, Salford Royal NHS Foundation Trust, Salford, UK.
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