• Je něco špatně v tomto záznamu ?

HDAC1 and HDAC3 underlie dynamic H3K9 acetylation during embryonic neurogenesis and in schizophrenia-like animals

J. Večeřa, E. Bártová, J. Krejčí, S. Legartová, D. Komůrková, J. Rudá-Kučerová, T. Štark, E. Dražanová, T. Kašpárek, A. Šulcová, FJ. Dekker, W. Szymanski, C. Seiser, G. Weitzer, R. Mechoulam, V. Micale, S. Kozubek,

. 2018 ; 233 (1) : 530-548. [pub] 20170503

Jazyk angličtina Země Spojené státy americké

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc18016721

Although histone acetylation is one of the most widely studied epigenetic modifications, there is still a lack of information regarding how the acetylome is regulated during brain development and pathophysiological processes. We demonstrate that the embryonic brain (E15) is characterized by an increase in H3K9 acetylation as well as decreases in the levels of HDAC1 and HDAC3. Moreover, experimental induction of H3K9 hyperacetylation led to the overexpression of NCAM in the embryonic cortex and depletion of Sox2 in the subventricular ependyma, which mimicked the differentiation processes. Inducing differentiation in HDAC1-deficient mouse ESCs resulted in early H3K9 deacetylation, Sox2 downregulation, and enhanced astrogliogenesis, whereas neuro-differentiation was almost suppressed. Neuro-differentiation of (wt) ESCs was characterized by H3K9 hyperacetylation that was associated with HDAC1 and HDAC3 depletion. Conversely, the hippocampi of schizophrenia-like animals showed H3K9 deacetylation that was regulated by an increase in both HDAC1 and HDAC3. The hippocampi of schizophrenia-like brains that were treated with the cannabinoid receptor-1 inverse antagonist AM251 expressed H3K9ac at the level observed in normal brains. Together, the results indicate that co-regulation of H3K9ac by HDAC1 and HDAC3 is important to both embryonic brain development and neuro-differentiation as well as the pathophysiology of a schizophrenia-like phenotype.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc18016721
003      
CZ-PrNML
005      
20230315103015.0
007      
ta
008      
180515s2018 xxu f 000 0|eng||
009      
AR
024    7_
$a 10.1002/jcp.25914 $2 doi
035    __
$a (PubMed)28300292
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxu
100    1_
$a Večeřa, Josef $u Faculty of Science, Department of Experimental Biology, Masaryk University, Brno, Czech Republic.
245    10
$a HDAC1 and HDAC3 underlie dynamic H3K9 acetylation during embryonic neurogenesis and in schizophrenia-like animals / $c J. Večeřa, E. Bártová, J. Krejčí, S. Legartová, D. Komůrková, J. Rudá-Kučerová, T. Štark, E. Dražanová, T. Kašpárek, A. Šulcová, FJ. Dekker, W. Szymanski, C. Seiser, G. Weitzer, R. Mechoulam, V. Micale, S. Kozubek,
520    9_
$a Although histone acetylation is one of the most widely studied epigenetic modifications, there is still a lack of information regarding how the acetylome is regulated during brain development and pathophysiological processes. We demonstrate that the embryonic brain (E15) is characterized by an increase in H3K9 acetylation as well as decreases in the levels of HDAC1 and HDAC3. Moreover, experimental induction of H3K9 hyperacetylation led to the overexpression of NCAM in the embryonic cortex and depletion of Sox2 in the subventricular ependyma, which mimicked the differentiation processes. Inducing differentiation in HDAC1-deficient mouse ESCs resulted in early H3K9 deacetylation, Sox2 downregulation, and enhanced astrogliogenesis, whereas neuro-differentiation was almost suppressed. Neuro-differentiation of (wt) ESCs was characterized by H3K9 hyperacetylation that was associated with HDAC1 and HDAC3 depletion. Conversely, the hippocampi of schizophrenia-like animals showed H3K9 deacetylation that was regulated by an increase in both HDAC1 and HDAC3. The hippocampi of schizophrenia-like brains that were treated with the cannabinoid receptor-1 inverse antagonist AM251 expressed H3K9ac at the level observed in normal brains. Together, the results indicate that co-regulation of H3K9ac by HDAC1 and HDAC3 is important to both embryonic brain development and neuro-differentiation as well as the pathophysiology of a schizophrenia-like phenotype.
650    _2
$a acetylace $7 D000107
650    _2
$a zvířata $7 D000818
650    _2
$a antipsychotika $x farmakologie $7 D014150
650    _2
$a mozek $x účinky léků $x embryologie $x enzymologie $x patologie $7 D001921
650    _2
$a antagonisté kanabinoidních receptorů $x farmakologie $7 D063387
650    _2
$a modely nemocí na zvířatech $7 D004195
650    _2
$a epigeneze genetická $7 D044127
650    _2
$a vývojová regulace genové exprese $7 D018507
650    _2
$a gestační stáří $7 D005865
650    _2
$a histondeacetylasa 1 $x antagonisté a inhibitory $x genetika $x metabolismus $7 D056284
650    _2
$a inhibitory histondeacetylas $x farmakologie $7 D056572
650    _2
$a histondeacetylasy $x genetika $x metabolismus $7 D006655
650    _2
$a histony $x metabolismus $7 D006657
650    _2
$a methylazoxymethanolacetát $7 D008746
650    _2
$a myši inbrední C57BL $7 D008810
650    _2
$a molekuly buněčné adheze nervové $x genetika $x metabolismus $7 D019006
650    12
$a neurogeneze $x účinky léků $7 D055495
650    _2
$a neurony $x účinky léků $x enzymologie $x patologie $7 D009474
650    _2
$a posttranslační úpravy proteinů $7 D011499
650    _2
$a potkani Sprague-Dawley $7 D017207
650    _2
$a receptor kanabinoidní CB1 $x antagonisté a inhibitory $x metabolismus $7 D043884
650    _2
$a transkripční faktory SOXB1 $x genetika $x metabolismus $7 D055748
650    _2
$a schizofrenie $x chemicky indukované $x farmakoterapie $x enzymologie $x genetika $7 D012559
650    _2
$a signální transdukce $7 D015398
650    _2
$a časové faktory $7 D013997
655    _2
$a časopisecké články $7 D016428
700    1_
$a Bártová, Eva $u Institute of Biophysics of the Czech Academy of Sciences, v.v.i., Brno, Czech Republic.
700    1_
$a Krejčí, Jana $u Institute of Biophysics of the Czech Academy of Sciences, v.v.i., Brno, Czech Republic.
700    1_
$a Legartová, Soňa $u Institute of Biophysics of the Czech Academy of Sciences, v.v.i., Brno, Czech Republic.
700    1_
$a Komůrková, Denisa $u Institute of Biophysics of the Czech Academy of Sciences, v.v.i., Brno, Czech Republic.
700    1_
$a Rudá-Kučerová, Jana $u Faculty of Medicine, Department of Pharmacology, Masaryk University, Brno, Czech Republic.
700    1_
$a Štark, Tibor $u Faculty of Medicine, Department of Pharmacology, Masaryk University, Brno, Czech Republic.
700    1_
$a Dražanová, Eva $u Faculty of Medicine, Department of Pharmacology, Masaryk University, Brno, Czech Republic. Institute of Scientific Instruments of the Czech Academy of Sciences, v.v.i., Brno, Czech Republic.
700    1_
$a Kašpárek, Tomáš $u Behavioral and Social Neuroscience Group, CEITEC-Central European Institute of Technology, Masaryk University, Brno, Czech Republic.
700    1_
$a Šulcová, Alexandra $u Behavioral and Social Neuroscience Group, CEITEC-Central European Institute of Technology, Masaryk University, Brno, Czech Republic.
700    1_
$a Dekker, Frank J $u Chemical and Pharmaceutical Biology, University of Groningen, Groningen, The Netherlands.
700    1_
$a Szymanski, Wiktor $u Department of Radiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
700    1_
$a Seiser, Christian $u Max F. Perutz Laboratories, Vienna Biocenter (VBC), Vienna, Austria.
700    1_
$a Weitzer, Georg $u Max F. Perutz Laboratories, Vienna Biocenter (VBC), Vienna, Austria.
700    1_
$a Mechoulam, Raphael, $u Faculty of Medicine, Institute for Drug Research, Hebrew University of Jerusalem, Jerusalem, Israel. $d 1930-2023 $7 xx0283446
700    1_
$a Micale, Vincenzo $u Behavioral and Social Neuroscience Group, CEITEC-Central European Institute of Technology, Masaryk University, Brno, Czech Republic. Department of Biomedical and Biotechnological Sciences, Section of Pharmacology, School of Medicine, University of Catania, Catania, Italy.
700    1_
$a Kozubek, Stanislav $u Faculty of Science, Department of Experimental Biology, Masaryk University, Brno, Czech Republic.
773    0_
$w MED00009981 $t Journal of cellular physiology $x 1097-4652 $g Roč. 233, č. 1 (2018), s. 530-548
856    41
$u https://pubmed.ncbi.nlm.nih.gov/28300292 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20180515 $b ABA008
991    __
$a 20230315103010 $b ABA008
999    __
$a ok $b bmc $g 1300345 $s 1013561
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2018 $b 233 $c 1 $d 530-548 $e 20170503 $i 1097-4652 $m Journal of cellular physiology $n J Cell Physiol $x MED00009981
LZP    __
$a Pubmed-20180515

Najít záznam

Citační ukazatele

Možnosti archivace