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Post-WBRT cognitive impairment and hippocampal neuronal depletion measured by in vivo metabolic MR spectroscopy: Results of prospective investigational study

P. Pospisil, T. Kazda, L. Hynkova, M. Bulik, M. Dobiaskova, P. Burkon, NN. Laack, P. Slampa, R. Jancalek,

. 2017 ; 122 (3) : 373-379. [pub] 20170104

Jazyk angličtina Země Irsko

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc18016819

BACKGROUND AND PURPOSE: The aim of this prospective study is to evaluate post-whole brain radiotherapy (WBRT) changes in hippocampal concentration of N-acetylaspartate (h-tNAA) as a marker of neuronal loss and to correlate those changes to neurocognitive function. MATERIAL AND METHODS: Thirty-five patients with brain metastases underwent baseline single slice multi-voxel MR spectroscopy (MRS) examination for measurement of hippocampal h-tNAA together with baseline battery of neurocognitive tests focused on memory (Auditory Verbal Learning Test and Brief Visuospatial Memory Test - Revised) as well as quality of life questionnaires (EORTC QLQ-C30 a EORTC QLQ-BN20). Eighteen patients completed follow-up evaluation four months after standard WBRT (2 laterolateral fields, 10×3.0Gy, 6MV photons) and were included in this analysis. MRS and cognitive examinations were repeated and compared to baseline measurements. RESULTS: Statistically significant decreases in h-tNAA were observed in the right (8.52-7.42mM; -12.9%, 95%CI: -7.6 to -16.4%) as well as in the left hippocampus (8.64-7.60mM; -12%, 95%CI: -7.9 to -16.2%). Statistically significant decline was observed in all AVLT and BVMT-R subtests with exception of AVLT_Recognition. Quality of life declined after WBRT (mean Δ -14.1±20.3 points in transformed 0-100 point scale; p=0.018) with no correlation to changes in hippocampal metabolite concentrations. Moderate positive correlation was observed between left h-tNAA concentration decrease and AVLT_TR decline (r=+0.32; p=0.24) as well as with AVLT_DR (r=+0.33; p=0.22) decline. Changes in right h-tNAA/Cr negatively correlated with AVLT_DR (r=-0.48; p=0.061). No correlation between right hippocampus h-tNAA and memory decline (AVLT) was observed. CONCLUSIONS: Our results suggest hippocampal NAA concentrations decline after WBRT and MRS may be a useful biomarker for monitoring neuronal loss after radiotherapy.

Citace poskytuje Crossref.org

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$a BACKGROUND AND PURPOSE: The aim of this prospective study is to evaluate post-whole brain radiotherapy (WBRT) changes in hippocampal concentration of N-acetylaspartate (h-tNAA) as a marker of neuronal loss and to correlate those changes to neurocognitive function. MATERIAL AND METHODS: Thirty-five patients with brain metastases underwent baseline single slice multi-voxel MR spectroscopy (MRS) examination for measurement of hippocampal h-tNAA together with baseline battery of neurocognitive tests focused on memory (Auditory Verbal Learning Test and Brief Visuospatial Memory Test - Revised) as well as quality of life questionnaires (EORTC QLQ-C30 a EORTC QLQ-BN20). Eighteen patients completed follow-up evaluation four months after standard WBRT (2 laterolateral fields, 10×3.0Gy, 6MV photons) and were included in this analysis. MRS and cognitive examinations were repeated and compared to baseline measurements. RESULTS: Statistically significant decreases in h-tNAA were observed in the right (8.52-7.42mM; -12.9%, 95%CI: -7.6 to -16.4%) as well as in the left hippocampus (8.64-7.60mM; -12%, 95%CI: -7.9 to -16.2%). Statistically significant decline was observed in all AVLT and BVMT-R subtests with exception of AVLT_Recognition. Quality of life declined after WBRT (mean Δ -14.1±20.3 points in transformed 0-100 point scale; p=0.018) with no correlation to changes in hippocampal metabolite concentrations. Moderate positive correlation was observed between left h-tNAA concentration decrease and AVLT_TR decline (r=+0.32; p=0.24) as well as with AVLT_DR (r=+0.33; p=0.22) decline. Changes in right h-tNAA/Cr negatively correlated with AVLT_DR (r=-0.48; p=0.061). No correlation between right hippocampus h-tNAA and memory decline (AVLT) was observed. CONCLUSIONS: Our results suggest hippocampal NAA concentrations decline after WBRT and MRS may be a useful biomarker for monitoring neuronal loss after radiotherapy.
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$a Kazda, Tomas $u Department of Radiation Oncology, Faculty of Medicine, Masaryk University, Brno, Czech Republic; Department of Radiation Oncology, Masaryk Memorial Cancer Institute, Brno, Czech Republic; International Clinical Research Center, St. Anne's University Hospital Brno, Czech Republic.
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$a Hynkova, Ludmila $u Department of Radiation Oncology, Faculty of Medicine, Masaryk University, Brno, Czech Republic; Department of Radiation Oncology, Masaryk Memorial Cancer Institute, Brno, Czech Republic.
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$a Dobiaskova, Marie $u Department of Clinical Psychology, St. Anne's University Hospital Brno, Czech Republic.
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$a Burkon, Petr $u Department of Radiation Oncology, Faculty of Medicine, Masaryk University, Brno, Czech Republic; Department of Radiation Oncology, Masaryk Memorial Cancer Institute, Brno, Czech Republic.
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$a Laack, Nadia N $u Department of Radiation Oncology, Mayo Clinic, Rochester, United States.
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$a Slampa, Pavel $u Department of Radiation Oncology, Faculty of Medicine, Masaryk University, Brno, Czech Republic; Department of Radiation Oncology, Masaryk Memorial Cancer Institute, Brno, Czech Republic.
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$a Jancalek, Radim $u Department of Neurosurgery - St. Anne's University Hospital Brno, Faculty of Medicine, Masaryk University, Czech Republic; Department of Neurosurgery, St. Anne's University Hospital Brno, Czech Republic. Electronic address: radim.jancalek@fnusa.cz.
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