• Something wrong with this record ?

Searching for New Targets and Treatments in the Battle Against Squamous Cell Carcinoma of the Head and Neck, with Specific Focus on Tumours of the Tongue

N. Sgaramella, X. Gu, L. Boldrup, PJ. Coates, R. Fahraeus, L. Califano, G. Tartaro, G. Colella, LN. Spaak, A. Strom, T. Wilms, LL. Muzio, GD. Orabona, M. Santagata, L. Loljung, R. Rossiello, K. Danielsson, K. Strindlund, S. Lillqvist, K. Nylander,

. 2018 ; 18 (3) : 214-218.

Language English Country United Arab Emirates

Document type Journal Article, Review

Persistent link   https://www.medvik.cz/link/bmc18024387

Squamous cell carcinoma of the head and neck, SCCHN, is a heterogeneous group of tumours not only concerning the site of origin but also regarding aetiology. The 5-year survival for the whole group of SCCHN tumours has not significantly improved over the last 20-25 years. Apart from tumour spread to lymph nodes, N status, gains and losses of specific chromosomes are the only factors shown to be independent prognostic markers for these tumours. Worldwide, an increasing number of people ≤ 40 years are seen being affected by tongue SCC, the most common tumour within the SCCHN group. Even without any clinical signs of metastasis, up to 30% of all tongue SCC have histologically detectable spread to lymph nodes. In this mini review, field cancerization, tumour microenvironment, the so called EMT (epithelial mesenchymal transition) process and the role of viruses in development of SCCHN are discussed as well as potential new therapeutic targets. For the group of tongue SCC, with the increasing incidence seen in young patients and particularly women, new data with impact on prognosis and treatment are urgently needed. But as long as data from the analyses of several sub sites are presented as valid for the whole group of tumours, this vital point is missed.

References provided by Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc18024387
003      
CZ-PrNML
005      
20180712092738.0
007      
ta
008      
180709s2018 ts f 000 0|eng||
009      
AR
024    7_
$a 10.2174/1568026618666180116121624 $2 doi
035    __
$a (PubMed)29345578
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a ts
100    1_
$a Sgaramella, Nicola $u Department of Medical Biosciences, Umea University, Umea, Sweden. Department of Medical, Surgical and Dental Specialties, Second University of Naples, Multidisciplinary Naples, Italy. Department of Neuroscience Reproductive and Dentistry Sciences, University of Naples Federico II, Naples, Italy.
245    10
$a Searching for New Targets and Treatments in the Battle Against Squamous Cell Carcinoma of the Head and Neck, with Specific Focus on Tumours of the Tongue / $c N. Sgaramella, X. Gu, L. Boldrup, PJ. Coates, R. Fahraeus, L. Califano, G. Tartaro, G. Colella, LN. Spaak, A. Strom, T. Wilms, LL. Muzio, GD. Orabona, M. Santagata, L. Loljung, R. Rossiello, K. Danielsson, K. Strindlund, S. Lillqvist, K. Nylander,
520    9_
$a Squamous cell carcinoma of the head and neck, SCCHN, is a heterogeneous group of tumours not only concerning the site of origin but also regarding aetiology. The 5-year survival for the whole group of SCCHN tumours has not significantly improved over the last 20-25 years. Apart from tumour spread to lymph nodes, N status, gains and losses of specific chromosomes are the only factors shown to be independent prognostic markers for these tumours. Worldwide, an increasing number of people ≤ 40 years are seen being affected by tongue SCC, the most common tumour within the SCCHN group. Even without any clinical signs of metastasis, up to 30% of all tongue SCC have histologically detectable spread to lymph nodes. In this mini review, field cancerization, tumour microenvironment, the so called EMT (epithelial mesenchymal transition) process and the role of viruses in development of SCCHN are discussed as well as potential new therapeutic targets. For the group of tongue SCC, with the increasing incidence seen in young patients and particularly women, new data with impact on prognosis and treatment are urgently needed. But as long as data from the analyses of several sub sites are presented as valid for the whole group of tumours, this vital point is missed.
650    _2
$a protinádorové látky $x chemie $x farmakologie $7 D000970
650    _2
$a antivirové látky $x chemie $x farmakologie $7 D000998
650    _2
$a spinocelulární karcinom $x farmakoterapie $x virologie $7 D002294
650    _2
$a screeningové testy protinádorových léčiv $7 D004354
650    _2
$a nádory hlavy a krku $x farmakoterapie $x virologie $7 D006258
650    _2
$a virus Epsteinův-Barrové $x účinky léků $7 D004854
650    _2
$a lidé $7 D006801
650    _2
$a mikrobiální testy citlivosti $7 D008826
650    _2
$a Papillomaviridae $x účinky léků $7 D027383
650    _2
$a vztahy mezi strukturou a aktivitou $7 D013329
650    _2
$a nádory jazyka $x farmakoterapie $x virologie $7 D014062
650    _2
$a nádorové mikroprostředí $x účinky léků $7 D059016
655    _2
$a časopisecké články $7 D016428
655    _2
$a přehledy $7 D016454
700    1_
$a Gu, Xiaolian $u Department of Medical Biosciences, Umea University, Umea, Sweden.
700    1_
$a Boldrup, Linda $u Department of Medical Biosciences, Umea University, Umea, Sweden.
700    1_
$a Coates, Philip J $u RECAMO, Masaryk Memorial Cancer Institute, Zluty kopec 7, 656 53 Brno, Czech Republic.
700    1_
$a Fahraeus, Robin $u Department of Medical Biosciences, Umea University, Umea, Sweden. RECAMO, Masaryk Memorial Cancer Institute, Zluty kopec 7, 656 53 Brno, Czech Republic. University Paris Diderot, INSERM UMRS1162, 27 rue Juliette Dodu, Paris, 75010, France.
700    1_
$a Califano, Luigi $u Department of Neuroscience Reproductive and Dentistry Sciences, University of Naples Federico II, Naples, Italy.
700    1_
$a Tartaro, Gianpaolo $u Department of Medical, Surgical and Dental Specialties, Second University of Naples, Multidisciplinary Naples, Italy.
700    1_
$a Colella, Giuseppe $u Department of Medical, Surgical and Dental Specialties, Second University of Naples, Multidisciplinary Naples, Italy.
700    1_
$a Spaak, Lena Norberg $u Department of Clinical Sciences/ENT, Umea University, Umea, Sweden.
700    1_
$a Strom, Adrian $u Department of Clinical Sciences/ENT, Umea University, Umea, Sweden.
700    1_
$a Wilms, Torben $u Department of Clinical Sciences/ENT, Umea University, Umea, Sweden.
700    1_
$a Muzio, Lorenzo Lo $u Department of Clinical and Experimental Medicine, University of Foggia, 71122 Foggia, Italy.
700    1_
$a Orabona, Giovanni Dell'Aversana $u Department of Neuroscience Reproductive and Dentistry Sciences, University of Naples Federico II, Naples, Italy.
700    1_
$a Santagata, Mario $u Department of Medical, Surgical and Dental Specialties, Second University of Naples, Multidisciplinary Naples, Italy.
700    1_
$a Loljung, Lotta $u Department of Medical Biosciences, Umea University, Umea, Sweden.
700    1_
$a Rossiello, Riccardo $u Dipartimento Universitario di Anatomia Patologica, Seconda Universita' Degli Studi di Napoli, Piazza Miraglia, Naples, Italy.
700    1_
$a Danielsson, Karin $u Department of Odontology, Umea University, Umea, Sweden.
700    1_
$a Strindlund, Klas $u Department of Medical Biosciences, Umea University, Umea, Sweden.
700    1_
$a Lillqvist, Sandra $u Department of Medical Biosciences, Umea University, Umea, Sweden.
700    1_
$a Nylander, Karin $u Department of Medical Biosciences, Umea University, Umea, Sweden.
773    0_
$w MED00007896 $t Current topics in medicinal chemistry $x 1873-4294 $g Roč. 18, č. 3 (2018), s. 214-218
856    41
$u https://pubmed.ncbi.nlm.nih.gov/29345578 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20180709 $b ABA008
991    __
$a 20180712093031 $b ABA008
999    __
$a ok $b bmc $g 1316518 $s 1021308
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2018 $b 18 $c 3 $d 214-218 $i 1873-4294 $m Current topics in medicinal chemistry $n Curr Top Med Chem $x MED00007896
LZP    __
$a Pubmed-20180709

Find record

Citation metrics

Archiving options