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Hop Phytochemicals and Their Potential Role in Metabolic Syndrome Prevention and Therapy
P. Dostálek, M. Karabín, L. Jelínek,
Language English Country Switzerland
Document type Journal Article, Review
NLK
Directory of Open Access Journals
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PubMed Central
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- MeSH
- Flavonoids chemistry pharmacology therapeutic use MeSH
- Phytochemicals chemistry pharmacology therapeutic use MeSH
- Glucose Tolerance Test MeSH
- Humulus chemistry MeSH
- Humans MeSH
- Metabolic Syndrome drug therapy prevention & control MeSH
- Lipid Metabolism drug effects MeSH
- Molecular Structure MeSH
- Propiophenones pharmacology therapeutic use MeSH
- Body Weight drug effects MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
Historically, hop cones (Humulus lupulus) have been used since ancient times as a remedy for many ailments and, as a source of polyphenols and bitter acids, is very effective in the treatment of metabolic syndrome (MS). Hop flavonoids, particularly xanthohumol (XN), are substances with hypoglycemic, antihyperlipidemic, and antiobesity activities. Iso-α-acids (IAA) and matured hop bitter acids (MHBA) improve health by influencing lipid metabolism, glucose tolerance, and body weight. The modulatory effect of IAA and MHBA on lipid metabolism may also be responsible for a loss in body weight. These results suggest promising applications for IAA, MHBA, and XN in humans, particularly in the prevention of diet-induced obesity and diabetes.
References provided by Crossref.org
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- $a Historically, hop cones (Humulus lupulus) have been used since ancient times as a remedy for many ailments and, as a source of polyphenols and bitter acids, is very effective in the treatment of metabolic syndrome (MS). Hop flavonoids, particularly xanthohumol (XN), are substances with hypoglycemic, antihyperlipidemic, and antiobesity activities. Iso-α-acids (IAA) and matured hop bitter acids (MHBA) improve health by influencing lipid metabolism, glucose tolerance, and body weight. The modulatory effect of IAA and MHBA on lipid metabolism may also be responsible for a loss in body weight. These results suggest promising applications for IAA, MHBA, and XN in humans, particularly in the prevention of diet-induced obesity and diabetes.
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