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Major transcriptional changes observed in the Fulani, an ethnic group less susceptible to malaria

JE. Quin, I. Bujila, M. Chérif, GS. Sanou, Y. Qu, M. Vafa Homann, A. Rolicka, SB. Sirima, MA. O'Connell, A. Lennartsson, M. Troye-Blomberg, I. Nebie, AK. Östlund Farrants,

. 2017 ; 6 (-) : . [pub] 20170919

Language English Country England, Great Britain

Document type Journal Article, Research Support, Non-U.S. Gov't

Persistent link   https://www.medvik.cz/link/bmc18024634

The Fulani ethnic group has relatively better protection from Plasmodium falciparum malaria, as reflected by fewer symptomatic cases of malaria, lower infection rates, and lower parasite densities compared to sympatric ethnic groups. However, the basis for this lower susceptibility to malaria by the Fulani is unknown. The incidence of classic malaria resistance genes are lower in the Fulani than in other sympatric ethnic populations, and targeted SNP analyses of other candidate genes involved in the immune response to malaria have not been able to account for the observed difference in the Fulani susceptibility to P.falciparum. Therefore, we have performed a pilot study to examine global transcription and DNA methylation patterns in specific immune cell populations in the Fulani to elucidate the mechanisms that confer the lower susceptibility to P.falciparum malaria. When we compared uninfected and infected Fulani individuals, in contrast to uninfected and infected individuals from the sympatric ethnic group Mossi, we observed a key difference: a strong transcriptional response was only detected in the monocyte fraction of the Fulani, where over 1000 genes were significantly differentially expressed upon P.falciparum infection.

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$a The Fulani ethnic group has relatively better protection from Plasmodium falciparum malaria, as reflected by fewer symptomatic cases of malaria, lower infection rates, and lower parasite densities compared to sympatric ethnic groups. However, the basis for this lower susceptibility to malaria by the Fulani is unknown. The incidence of classic malaria resistance genes are lower in the Fulani than in other sympatric ethnic populations, and targeted SNP analyses of other candidate genes involved in the immune response to malaria have not been able to account for the observed difference in the Fulani susceptibility to P.falciparum. Therefore, we have performed a pilot study to examine global transcription and DNA methylation patterns in specific immune cell populations in the Fulani to elucidate the mechanisms that confer the lower susceptibility to P.falciparum malaria. When we compared uninfected and infected Fulani individuals, in contrast to uninfected and infected individuals from the sympatric ethnic group Mossi, we observed a key difference: a strong transcriptional response was only detected in the monocyte fraction of the Fulani, where over 1000 genes were significantly differentially expressed upon P.falciparum infection.
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$a Bujila, Ioana $u Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden.
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$a Chérif, Mariama $u Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou, Burkina Faso. Université Polytechnique de Bobo-Dioulasso, Bobo-Dioulasso, Burkina Faso.
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$a Sanou, Guillaume S $u Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou, Burkina Faso.
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$a Qu, Ying $u Department of Biosciences and Nutrition, Karolinska Institute, Stockholm, Sweden.
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$a Vafa Homann, Manijeh $u Unit of Infectious Diseases, Department of Medicine, Karolinska Institute, Stockholm, Sweden.
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$a Rolicka, Anna $u Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden.
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$a Sirima, Sodiomon B $u Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou, Burkina Faso.
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$a O'Connell, Mary A $u Central European Institute of Technology, Brno, Czech Republic.
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$a Lennartsson, Andreas $u Department of Biosciences and Nutrition, Karolinska Institute, Stockholm, Sweden.
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$a Troye-Blomberg, Marita $u Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden.
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$a Nebie, Issa $u Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou, Burkina Faso.
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$a Östlund Farrants, Ann-Kristin $u Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden.
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