Detail
Article
Online article
FT
Medvik - BMC
  • Something wrong with this record ?

Cardiac morphofunctional characteristics of transgenic rats with overexpression of the bradykinin B1 receptor in the endothelium

R. F. Levy, A. J. Serra, E. L. Antonio, L. Dos Santos, D. S. Bocalini, J. B. Pesquero, M. Bader, V. F. Merino, H. A. de Oliveira, E. C. de Arruda Veiga, J. A. Silva, P. J. Tucci

. 2017 ; 66 (6) : 925-932. [pub] 20170922

Language English Country Czech Republic

Document type Journal Article

Persistent link   https://www.medvik.cz/link/bmc18027502

Our aim was to evaluate whether endothelial overexpressing of the bradykinin B1 receptor could be associated with altered left ventricular and myocardial performance. Echocardiography and hemodynamic were employed to assess left ventricular morphology and function in Sprague Dawley transgenic rats overexpressing the endothelial bradykinin B1 receptor (Tie2B1 rats). The myocardial inotropism was evaluated on papillary muscles contracting in vitro. In Tie2B1 animals, an enlarged left ventricular cavity and lower fractional shortening coupled with a lower rate of pressure change values indicated depressed left ventricular performance. Papillary muscle mechanics revealed that both Tie2B1 and wild-type rat groups had the same contractile capacities under basal conditions; however, in transgenic animals, there was accentuated inotropism due to post-pause potentiation. Following treatment with the Arg(9)-BK agonist, Tie2B1 papillary muscles displayed a reduction in myocardial inotropism. Endothelial B1 receptor overexpression has expanded the LV cavity and worsened its function. There was an exacerbated response of papillary muscle in vitro to a prolonged resting pause, and the use of a B1 receptor agonist impairs myocardial inotropism.

References provided by Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc18027502
003      
CZ-PrNML
005      
20180815074339.0
007      
ta
008      
180807s2017 xr d f 000 0|eng||
009      
AR
024    7_
$a 10.33549/physiolres.933596 $2 doi
035    __
$a (PubMed)28937259
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xr
100    1_
$a Levy, R. F. $u Universidade Federal da Paraíba, João Pessoa, Paraíba, Brazil
245    10
$a Cardiac morphofunctional characteristics of transgenic rats with overexpression of the bradykinin B1 receptor in the endothelium / $c R. F. Levy, A. J. Serra, E. L. Antonio, L. Dos Santos, D. S. Bocalini, J. B. Pesquero, M. Bader, V. F. Merino, H. A. de Oliveira, E. C. de Arruda Veiga, J. A. Silva, P. J. Tucci
520    9_
$a Our aim was to evaluate whether endothelial overexpressing of the bradykinin B1 receptor could be associated with altered left ventricular and myocardial performance. Echocardiography and hemodynamic were employed to assess left ventricular morphology and function in Sprague Dawley transgenic rats overexpressing the endothelial bradykinin B1 receptor (Tie2B1 rats). The myocardial inotropism was evaluated on papillary muscles contracting in vitro. In Tie2B1 animals, an enlarged left ventricular cavity and lower fractional shortening coupled with a lower rate of pressure change values indicated depressed left ventricular performance. Papillary muscle mechanics revealed that both Tie2B1 and wild-type rat groups had the same contractile capacities under basal conditions; however, in transgenic animals, there was accentuated inotropism due to post-pause potentiation. Following treatment with the Arg(9)-BK agonist, Tie2B1 papillary muscles displayed a reduction in myocardial inotropism. Endothelial B1 receptor overexpression has expanded the LV cavity and worsened its function. There was an exacerbated response of papillary muscle in vitro to a prolonged resting pause, and the use of a B1 receptor agonist impairs myocardial inotropism.
650    _2
$a zvířata $7 D000818
650    _2
$a endoteliální buňky $x metabolismus $7 D042783
650    _2
$a genetická predispozice k nemoci $7 D020022
650    _2
$a mužské pohlaví $7 D008297
650    12
$a kontrakce myokardu $7 D009200
650    _2
$a papilární svaly $x metabolismus $x patofyziologie $7 D010210
650    _2
$a fenotyp $7 D010641
650    _2
$a potkani Sprague-Dawley $7 D017207
650    _2
$a potkani transgenní $7 D055647
650    _2
$a receptor bradykininu B1 $x genetika $x metabolismus $7 D043783
650    _2
$a upregulace $7 D015854
650    _2
$a dysfunkce levé srdeční komory $x genetika $x metabolismus $x patofyziologie $7 D018487
650    12
$a funkce levé komory srdeční $7 D016277
650    _2
$a remodelace komor $7 D020257
655    _2
$a časopisecké články $7 D016428
700    1_
$a Serra, A. J. $u Universidade Nove de Julho, São Paulo, SP, Brazil
700    1_
$a Antonio, E. L. $u Universidade Federal de São Paulo, São Paulo, SP, Brazil
700    1_
$a Dos Santos, L. $u Universidade Federal do Espírito Santo, Vitória, Espírito Santo, Brazil
700    1_
$a Bocalini, D. S. $u Universidade São Judas Tadeu, São Paulo, SP, Brazil
700    1_
$a Pesquero, J. B. $u Universidade Federal de São Paulo, São Paulo, SP, Brazil
700    1_
$a Bader, M. $u Max-Delbrück-Center for Molecular Medicine (MDC), Berlin-Buch, Germany
700    1_
$a Merino, V. F. $u Johns Hopkins University School of Medicine, Baltimore, USA
700    1_
$a Oliveira, H. A. de $u Universidade Nove de Julho, São Paulo, SP, Brazil
700    1_
$a Arruda Veiga, E. C. de $u Universidade Federal de São Paulo, São Paulo, SP, Brazil
700    1_
$a Silva, J. A. $u Universidade Nove de Julho, São Paulo, SP, Brazil
700    1_
$a Tucci, P. Jf. $u Universidade Federal de São Paulo, São Paulo, SP, Brazil
773    0_
$w MED00003824 $t Physiological research $x 1802-9973 $g Roč. 66, č. 6 (2017), s. 925-932
856    41
$u https://pubmed.ncbi.nlm.nih.gov/28937259 $y Pubmed
910    __
$a ABA008 $b A 4120 $c 266 $y 4 $z 0
990    __
$a 20180807 $b ABA008
991    __
$a 20180810144722 $b ABA008
999    __
$a ok $b bmc $g 1326206 $s 1024450
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2017 $b 66 $c 6 $d 925-932 $e 20170922 $i 1802-9973 $m Physiological research $n Physiol. Res. (Print) $x MED00003824
LZP    __
$b NLK118 $a Pubmed-20180807

Find record

Citation metrics

Archiving options