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In Vivo Evaluation of Short-Term Performance of New Three-Layer Collagen-Based Vascular Graft Designed for Low-Flow Peripheral Vascular Reconstructions

T. Grus, L. Lambert, M. Mlcek, H. Chlup, E. Honsova, M. Spacek, A. Burgetova, J. Lindner,

. 2018 ; 2018 (-) : 3519596. [pub] 20180227

Jazyk angličtina Země Spojené státy americké

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc18033136

Grantová podpora
NV15-27941A MZ0 CEP - Centrální evidence projektů

Aim: The aim of this study was to evaluate short-term patency of the new prosthetic graft and its structural changes after explantation. Methods: The study team developed a three-layer conduit composed of a scaffold made from polyester coated with collagen from the inner and outer side with an internal diameter of 6 mm. The conduit was implanted as a bilateral bypass to the carotid artery in 7 sheep and stenosis was created in selected animals. After a period of 161 days, the explants were evaluated as gross and microscopic specimens. Results: The initial flow rate (median ± IQR) in grafts with and without artificial stenosis was 120 ± 79 ml/min and 255 ± 255 ml/min, respectively. Graft occlusion occurred after 99 days in one of 13 conduits (patency rate: 92%). Wall-adherent thrombi occurred only in sharp curvatures in two grafts. Microscopic evaluation showed good engraftment and preserved structure in seven conduits; inflammatory changes with foci of bleeding, necrosis, and disintegration in four conduits; and narrowing of the graft due to thickening of the wall with multifocal separation of the outer layer in two conduits. Conclusions: This study demonstrates good short-term patency rates of a newly designed three-layer vascular graft even in low-flow conditions in a sheep model.

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$a Lambert, Lukas $u Department of Radiology, First Faculty of Medicine, Charles University and General University Hospital in Prague, U Nemocnice 2, 128 08 Prague 2, Czech Republic.
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$a Mlcek, Mikulas $u Institute of Physiology, First Faculty of Medicine, Charles University in Prague, Albertov 5, 128 00 Prague 2, Czech Republic.
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$a Chlup, Hynek $u Department of Mechanics, Biomechanics and Mechatronics, Faculty of Mechanical Engineering, Czech Technical University in Prague, Technicka 4, 166 07 Prague 6, Czech Republic.
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$a Honsova, Eva $u Department Pathology, Institute for Clinical and Experimental Medicine, Vídeňská 9, 140 21 Prague 4, Czech Republic.
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$a Spacek, Miroslav $u Department of Cardiovascular Surgery, First Faculty of Medicine, Charles University and General University Hospital in Prague, U Nemocnice 2, 128 08 Prague 2, Czech Republic.
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$a Burgetova, Andrea $u Department of Radiology, First Faculty of Medicine, Charles University and General University Hospital in Prague, U Nemocnice 2, 128 08 Prague 2, Czech Republic.
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$a Lindner, Jaroslav $u Department of Cardiovascular Surgery, First Faculty of Medicine, Charles University and General University Hospital in Prague, U Nemocnice 2, 128 08 Prague 2, Czech Republic.
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