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Silica-based nanoparticles are efficient delivery systems for temoporfin

I. Brezániová, K. Záruba, J. Králová, A. Sinica, H. Adámková, P. Ulbrich, P. Poučková, M. Hrubý, P. Štěpánek, V. Král,

. 2018 ; 21 (-) : 275-284. [pub] 20171227

Jazyk angličtina Země Nizozemsko

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc18033418

Grantová podpora
NV16-30544A MZ0 CEP - Centrální evidence projektů

BACKGROUND: Drug targeting using functionalized nanoparticles to advance their transport to the dedicated site became a new standard in novel anticancer methods Anticancer photodynamic therapy also takes benefit from using nanoparticles by means of increasing targeting efficiency and decreased side effect. With this in mind, the silica-based nanoparticles, as drug delivery systems for the second-generation photosensitizer 5,10,15,20-tetrakis(m-hydroxyphenyl) chlorin (temoporfin) were developed. METHODS: In order to determine the stability and therapeutic performance of the selected nanomaterials in physiological fluids, their physicochemical properties (i.e. size, polydispersity, zeta potential) were measured by dynamic light scattering technique and the diameter and the morphology of the individual particles were visualized by a transmission electron microscopy. Their efficacy was compared with commercial temoporfin formulation in terms of in vitro phototoxicity in 4T1 (murine mammary carcinoma) and of in vivo anticancer effect in Nu/Nu mice bearing MDA-MB-231 tumors. RESULTS AND CONCLUSIONS: The two types of silica nanoparticles, porous and non-porous and with different surface chemical modification, were involved and critically compared within the study. Their efficacy was successfully demonstrated and was shown to be superior in comparison with commercial temoporfin formulation in terms of in vitro phototoxicity and cellular uptake as well as in terms of in vivo anticancer effect on human breast cancer model. Temoporfin-loaded silica nanoparticles also passed through the blood-brain barrier showing potential for the treatment of brain metastases.

Citace poskytuje Crossref.org

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$a Záruba, Kamil $u Department of Analytical Chemistry, University of Chemistry and Technology Prague, Technicka 5, 166 28 Prague 6, Czech Republic.
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$a Sinica, Alla $u Department of Analytical Chemistry, University of Chemistry and Technology Prague, Technicka 5, 166 28 Prague 6, Czech Republic.
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$a Adámková, Hana $u Department of Analytical Chemistry, University of Chemistry and Technology Prague, Technicka 5, 166 28 Prague 6, Czech Republic.
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$a Ulbrich, Pavel $u Department of Biochemistry and Microbiology, University of Chemistry and Technology Prague, Technicka 5, 166 28 Prague 6, Czech Republic.
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$a Poučková, Pavla $u First Faculty of Medicine, Charles University in Prague, Kateřinská 32, Prague 2, Czech Republic.
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$a Hrubý, Martin $u Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, Heyrovsky sq. 2, 162 06 Prague 6, Czech Republic.
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$a Král, Vladimír $u Department of Analytical Chemistry, University of Chemistry and Technology Prague, Technicka 5, 166 28 Prague 6, Czech Republic; BIOCEV, Průmyslová 595, 252 50Vestec, Czech Republic. Electronic address: vladimir.kral@vscht.cz.
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