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Subclinical Cardiac Dysfunction and Brain Health in Midlife: CARDIA (Coronary Artery Risk Development in Young Adults) Brain Magnetic Resonance Imaging Substudy
P. Cermakova, M. Muller, AC. Armstrong, D. Religa, RN. Bryan, JAC. Lima, LJ. Launer,
Language English Country England, Great Britain
Document type Journal Article, Multicenter Study
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- MeSH
- Global Health MeSH
- Adult MeSH
- Ventricular Dysfunction, Left complications diagnosis physiopathology MeSH
- Echocardiography MeSH
- Ventricular Function, Left physiology MeSH
- Risk Assessment methods MeSH
- Brain Ischemia diagnosis epidemiology etiology MeSH
- Coronary Vessels diagnostic imaging MeSH
- Humans MeSH
- Magnetic Resonance Imaging methods MeSH
- Young Adult MeSH
- Morbidity trends MeSH
- Brain MeSH
- Risk Factors MeSH
- Heart Ventricles diagnostic imaging physiopathology MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Young Adult MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Multicenter Study MeSH
BACKGROUND: We investigated whether cardiac parameters in young adulthood are associated with indicators of brain health in midlife. METHODS AND RESULTS: This study includes 648 participants from the CARDIA (Coronary Artery Risk Development in Young Adults) study (52% women, 38% black). We studied associations of cardiac parameters assessed by echocardiography (left ventricular ejection fraction, left atrial volume, and left ventricular mass) in young adulthood (mean age: 30 years) with brain measures obtained by magnetic resonance imaging (total brain, gray and white matter volume, white matter integrity, abnormal white matter) in midlife (mean age: 50 years). In 406 individuals with complete measurements, higher left atrial volume was associated with lower white matter fractional anisotropy, independent of traditional cardiovascular risk factors (β=-0.002; P <0.02). The association was strongest in black participants and in men. CONCLUSIONS: Higher left atrial volume in early adulthood is associated with impairment of white matter integrity in midlife. Interventions to improve cardiac function in young adults may benefit brain health and should be targeted in particular at black men.
Department of Radiology University of Pennsylvania Philadelphia PA
Division of Cardiology Johns Hopkins University School of Medicine Baltimore MD
Laboratory of Epidemiology and Population Sciences National Institute on Aging Bethesda MD
References provided by Crossref.org
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- $a BACKGROUND: We investigated whether cardiac parameters in young adulthood are associated with indicators of brain health in midlife. METHODS AND RESULTS: This study includes 648 participants from the CARDIA (Coronary Artery Risk Development in Young Adults) study (52% women, 38% black). We studied associations of cardiac parameters assessed by echocardiography (left ventricular ejection fraction, left atrial volume, and left ventricular mass) in young adulthood (mean age: 30 years) with brain measures obtained by magnetic resonance imaging (total brain, gray and white matter volume, white matter integrity, abnormal white matter) in midlife (mean age: 50 years). In 406 individuals with complete measurements, higher left atrial volume was associated with lower white matter fractional anisotropy, independent of traditional cardiovascular risk factors (β=-0.002; P <0.02). The association was strongest in black participants and in men. CONCLUSIONS: Higher left atrial volume in early adulthood is associated with impairment of white matter integrity in midlife. Interventions to improve cardiac function in young adults may benefit brain health and should be targeted in particular at black men.
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