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Comparative analysis of murine T-cell receptor repertoires
M. Izraelson, TO. Nakonechnaya, B. Moltedo, ES. Egorov, SA. Kasatskaya, EV. Putintseva, IZ. Mamedov, DB. Staroverov, II. Shemiakina, MY. Zakharova, AN. Davydov, DA. Bolotin, M. Shugay, DM. Chudakov, AY. Rudensky, OV. Britanova,
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články, práce podpořená grantem, přehledy
NLK
Free Medical Journals
od 1958 do Před 1 rokem
PubMed Central
od 1958 do 2021
Medline Complete (EBSCOhost)
od 1958-01-01 do Před 1 rokem
Wiley Free Content
od 1996 do Před 1 rokem
PubMed
29080364
DOI
10.1111/imm.12857
Knihovny.cz E-zdroje
- MeSH
- buněčná imunita fyziologie MeSH
- hypervariabilní oblasti genetika imunologie MeSH
- myši MeSH
- T-lymfocyty - podskupiny cytologie imunologie MeSH
- zvířata MeSH
- Check Tag
- myši MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
For understanding the rules and laws of adaptive immunity, high-throughput profiling of T-cell receptor (TCR) repertoires becomes a powerful tool. The structure of TCR repertoires is instructive even before the antigen specificity of each particular receptor becomes available. It embodies information about the thymic and peripheral selection of T cells; the readiness of an adaptive immunity to withstand new challenges; the character, magnitude and memory of immune responses; and the aetiological and functional proximity of T-cell subsets. Here, we describe our current analytical approaches for the comparative analysis of murine TCR repertoires, and show several examples of how these approaches can be applied for particular experimental settings. We analyse the efficiency of different metrics used for estimation of repertoire diversity, repertoire overlap, V-gene and J-gene segments usage similarity, and amino acid composition of CDR3. We discuss basic differences of these metrics and their advantages and limitations in different experimental models, and we provide guidelines for choosing an efficient way to lead a comparative analysis of TCR repertoires. Applied to the various known and newly developed mouse models, such analysis should allow us to disentangle multiple sophisticated puzzles in adaptive immunity.
Central European Institute of Technology Brno Czech Republic
Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry Moscow Russia
Citace poskytuje Crossref.org
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