Detail
Article
Online article
FT
Medvik - BMC
  • Something wrong with this record ?

Subversion of innate immune responses by Francisella involves the disruption of TRAF3 and TRAF6 signalling complexes

D. Putzova, S. Panda, A. Härtlova, J. Stulík, NO. Gekara,

. 2017 ; 19 (11) : . [pub] 20170816

Language English Country England, Great Britain

Document type Journal Article, Research Support, Non-U.S. Gov't

Persistent link   https://www.medvik.cz/link/bmc18033807

The success of pathogens depends on their ability to circumvent immune defences. Francisella tularensis is one of the most infectious bacteria known. The remarkable virulence of Francisella is believed to be due to its capacity to evade or subvert the immune system, but how remains obscure. Here, we show that Francisella triggers but concomitantly inhibits the Toll-like receptor, RIG-I-like receptor, and cytoplasmic DNA pathways. Francisella subverts these pathways at least in part by inhibiting K63-linked polyubiquitination and assembly of TRAF6 and TRAF3 complexes that control the transcriptional responses of pattern recognition receptors. We show that this mode of inhibition requires a functional type VI secretion system and/or the presence of live bacteria in the cytoplasm. The ability of Francisella to enter the cytosol while simultaneously inhibiting multiple pattern recognition receptor pathways may account for the notable capacity of this bacterium to invade and proliferate in the host without evoking a self-limiting innate immune response.

References provided by Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc18033807
003      
CZ-PrNML
005      
20181023105445.0
007      
ta
008      
181008s2017 enk f 000 0|eng||
009      
AR
024    7_
$a 10.1111/cmi.12769 $2 doi
035    __
$a (PubMed)28745813
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a enk
100    1_
$a Putzova, Daniela $u Department of Molecular Biology, The Laboratory for Molecular Infection Medicine Sweden (MIMS), Umeå Centre for Microbial Research (UCMR), Umeå University, Umeå, Sweden. Department of Molecular Pathology and Biology, Faculty of Military Health Sciences, University of Defense, Hradec Králové, Czech Republic.
245    10
$a Subversion of innate immune responses by Francisella involves the disruption of TRAF3 and TRAF6 signalling complexes / $c D. Putzova, S. Panda, A. Härtlova, J. Stulík, NO. Gekara,
520    9_
$a The success of pathogens depends on their ability to circumvent immune defences. Francisella tularensis is one of the most infectious bacteria known. The remarkable virulence of Francisella is believed to be due to its capacity to evade or subvert the immune system, but how remains obscure. Here, we show that Francisella triggers but concomitantly inhibits the Toll-like receptor, RIG-I-like receptor, and cytoplasmic DNA pathways. Francisella subverts these pathways at least in part by inhibiting K63-linked polyubiquitination and assembly of TRAF6 and TRAF3 complexes that control the transcriptional responses of pattern recognition receptors. We show that this mode of inhibition requires a functional type VI secretion system and/or the presence of live bacteria in the cytoplasm. The ability of Francisella to enter the cytosol while simultaneously inhibiting multiple pattern recognition receptor pathways may account for the notable capacity of this bacterium to invade and proliferate in the host without evoking a self-limiting innate immune response.
650    _2
$a adaptorové proteiny signální transdukční $x genetika $7 D048868
650    _2
$a adaptorové proteiny vezikulární transportní $x genetika $7 D033942
650    _2
$a zvířata $7 D000818
650    _2
$a Francisella tularensis $x imunologie $x patogenita $7 D005604
650    _2
$a imunitní únik $x imunologie $7 D057131
650    _2
$a přirozená imunita $x imunologie $7 D007113
650    _2
$a myši $7 D051379
650    _2
$a myši inbrední C57BL $7 D008810
650    _2
$a myši knockoutované $7 D018345
650    _2
$a myeloidní diferenciační faktor 88 $x genetika $7 D053594
650    _2
$a receptory rozpoznávající vzory $x antagonisté a inhibitory $7 D051192
650    _2
$a faktor 3 asociovaný s receptory TNF $x metabolismus $7 D048008
650    _2
$a faktor 6 asociovaný s receptory TNF $x metabolismus $7 D048029
650    _2
$a tularemie $x imunologie $x mikrobiologie $x patologie $7 D014406
650    _2
$a sekreční systém typu VI $x metabolismus $7 D000069376
650    _2
$a ubikvitinace $x imunologie $7 D054875
655    _2
$a časopisecké články $7 D016428
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Panda, Swarupa $u Department of Molecular Biology, The Laboratory for Molecular Infection Medicine Sweden (MIMS), Umeå Centre for Microbial Research (UCMR), Umeå University, Umeå, Sweden.
700    1_
$a Härtlova, Anetta $u Department of Molecular Biology, The Laboratory for Molecular Infection Medicine Sweden (MIMS), Umeå Centre for Microbial Research (UCMR), Umeå University, Umeå, Sweden.
700    1_
$a Stulík, Jiří $u Department of Molecular Pathology and Biology, Faculty of Military Health Sciences, University of Defense, Hradec Králové, Czech Republic.
700    1_
$a Gekara, Nelson O $u Department of Molecular Biology, The Laboratory for Molecular Infection Medicine Sweden (MIMS), Umeå Centre for Microbial Research (UCMR), Umeå University, Umeå, Sweden.
773    0_
$w MED00007154 $t Cellular microbiology $x 1462-5822 $g Roč. 19, č. 11 (2017)
856    41
$u https://pubmed.ncbi.nlm.nih.gov/28745813 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20181008 $b ABA008
991    __
$a 20181023105952 $b ABA008
999    __
$a ok $b bmc $g 1340305 $s 1030801
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2017 $b 19 $c 11 $e 20170816 $i 1462-5822 $m Cellular microbiology $n Cell Microbiol $x MED00007154
LZP    __
$a Pubmed-20181008

Find record

Citation metrics

Archiving options