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ABCE1: A special factor that orchestrates translation at the crossroad between recycling and initiation
E. Mancera-Martínez, J. Brito Querido, LS. Valasek, A. Simonetti, Y. Hashem,
Language English Country United States
Document type Journal Article, Review, Research Support, Non-U.S. Gov't
NLK
Free Medical Journals
from 2004 to 1 year ago
Freely Accessible Science Journals
from 2004
PubMed Central
from 2009 to 1 year ago
Europe PubMed Central
from 2009 to 1 year ago
- MeSH
- ATP-Binding Cassette Transporters chemistry metabolism MeSH
- Peptide Elongation Factors MeSH
- Hydrolysis MeSH
- Peptide Chain Initiation, Translational * MeSH
- Peptide Initiation Factors metabolism MeSH
- Rabbits MeSH
- Models, Molecular MeSH
- Nucleosides chemistry MeSH
- Ribosomes metabolism MeSH
- Peptide Chain Termination, Translational MeSH
- Protein Binding MeSH
- Binding Sites MeSH
- Animals MeSH
- Check Tag
- Rabbits MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
For many years initiation and termination of mRNA translation have been studied separately. However, a direct link between these 2 isolated stages has been suggested by the fact that some initiation factors also control termination and can even promote ribosome recycling; i.e. the last stage where post-terminating 80S ribosomes are split to start a new round of initiation. Notably, it is now firmly established that, among other factors, ribosomal recycling critically requires the NTPase ABCE1. However, several earlier reports have proposed that ABCE1 also somehow participates in the initiation complex assembly. Based on an extended analysis of our recently published late-stage 48S initiation complex from rabbit, here we provide new mechanistic insights into this putative role of ABCE1 in initiation. This point of view represents the first structural evidence in which the regulatory role of the recycling factor ABCE1 in initiation is discussed and establishes a corner stone for elucidating the interplay between ABCE1 and several initiation factors during the transit from ribosomal recycling to formation of the elongation competent 80S initiation complex.
b Laboratory of Regulation of Gene Expression Institute of Microbiology ASCR Prague Czech Republic
CNRS Architecture et Réactivité de l'ARN UPR9002 Université de Strasbourg Strasbourg France
References provided by Crossref.org
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