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The burden and epidemiology of community-acquired central nervous system infections: a multinational study
H. Erdem, A. Inan, E. Guven, S. Hargreaves, L. Larsen, G. Shehata, E. Pernicova, E. Khan, L. Bastakova, S. Namani, A. Harxhi, T. Roganovic, B. Lakatos, S. Uysal, OR. Sipahi, A. Crisan, E. Miftode, R. Stebel, B. Jegorovic, Z. Fehér, C. Jekkel, N....
Jazyk angličtina Země Německo
Typ dokumentu časopisecké články, multicentrická studie
NLK
ProQuest Central
od 1997-01-01 do Před 1 rokem
Medline Complete (EBSCOhost)
od 2000-01-01 do Před 1 rokem
Health & Medicine (ProQuest)
od 1997-01-01 do Před 1 rokem
- MeSH
- dospělí MeSH
- hodnocení výsledků zdravotní péče MeSH
- infekce centrálního nervového systému epidemiologie etiologie mortalita MeSH
- infekce získané v komunitě epidemiologie etiologie mortalita MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladý dospělý MeSH
- průřezové studie MeSH
- retrospektivní studie MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- surveillance populace * MeSH
- věkové faktory MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- multicentrická studie MeSH
Risk assessment of central nervous system (CNS) infection patients is of key importance in predicting likely pathogens. However, data are lacking on the epidemiology globally. We performed a multicenter study to understand the burden of community-acquired CNS (CA-CNS) infections between 2012 and 2014. A total of 2583 patients with CA-CNS infections were included from 37 referral centers in 20 countries. Of these, 477 (18.5%) patients survived with sequelae and 227 (8.8%) died, and 1879 (72.7%) patients were discharged with complete cure. The most frequent infecting pathogens in this study were Streptococcus pneumoniae (n = 206, 8%) and Mycobacterium tuberculosis (n = 152, 5.9%). Varicella zoster virus and Listeria were other common pathogens in the elderly. Although staphylococci and Listeria resulted in frequent infections in immunocompromised patients, cryptococci were leading pathogens in human immunodeficiency virus (HIV)-positive individuals. Among the patients with any proven etiology, 96 (8.9%) patients presented with clinical features of a chronic CNS disease. Neurosyphilis, neurobrucellosis, neuroborreliosis, and CNS tuberculosis had a predilection to present chronic courses. Listeria monocytogenes, Staphylococcus aureus, M. tuberculosis, and S. pneumoniae were the most fatal forms, while sequelae were significantly higher for herpes simplex virus type 1 (p < 0.05 for all). Tackling the high burden of CNS infections globally can only be achieved with effective pneumococcal immunization and strategies to eliminate tuberculosis, and more must be done to improve diagnostic capacity.
Antalya Education and Research Hospital Antalya Turkey
Beytepe Murat Erdi Eker State Hospital Ankara Turkey
Clinic for Infectious Diseases University Hospital of Mostar Mostar Bosnia and Herzegovina
Department Maladies Infectieuses Institut Pasteur de Paris HPA Paris France
Department of Clinical Pathology Pamela Youde Nethersole Eastern Hospital Hong Kong SAR China
Department of Immunology and Allergy Losante Hospital Ankara Turkey
Department of Infectious Diseases Astana Medical University Astana Kazakhstan
Department of Infectious Diseases General Hospital Dubrovnik Dubrovnik Croatia
Department of Infectious Diseases Markusovszky University Teaching Hospital Szombathely Hungary
Department of Infectious Diseases Q Odense University Hospital Odense Denmark
Department of Infectious Diseases Saint Laszlo Hospital Budapest Hungary
Department of Infectious Diseases Tenon University Hospital Paris France
Department of Infectious Diseases Victor Babes University of Medicine and Pharmacy Timisoara Romania
Department of Infectious Diseases Zenica Cantonal Hospital Zenica Bosnia and Herzegovina
Department of Neurology and Psychiatry Assiut University Hospital Assiut Egypt
Department of Neurology Damascus Hospital Damascus Syria
Gulhane Medical Academy Blood Bank Clinical Microbiology Division Ankara Turkey
Hospital of Infectious Diseases Gr T Popa University of Medicine and Pharmacy Iasi Romania
Infection Control Department Saudi German Hospital Group Jeddah Saudi Arabia
Infectious Diseases Clinic University Clinical Center of Kosovo Prishtina Kosovo
Infectious Diseases Department Nouvel Hôpital Civil Strasbourg France
Infectious Diseases Team Department of Medicine Queen Elizabeth Hospital Hong Kong China
Infectious Diseases Unit CHU Bicètre Paris France
Neurology Team Department of Medicine Queen Elizabeth Hospital Hong Kong China
Service of Infectious Disease University Hospital Center of Tirana Tirana Albania
Shifa International Hospital Islamabad Pakistan
Unit of Infectious Diseases Azienda Ospedaliera Universitaria Integrata Verona Italy
University Clinical Center Tuzla Tuzla Bosnia and Herzegovina
University Division of Infectious and Tropical Diseases Piazza Spedali Civili 25123 Brescia Italy
Citace poskytuje Crossref.org
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- $a Erdem, H $u Principal Coordinator of ID-IRI, Ankara, Turkey. hakanerdem1969@yahoo.com. Department of Infectious Diseases and Clinical Microbiology, Gulhane Medical Academy, 06010, Etlik, Ankara, Turkey. hakanerdem1969@yahoo.com.
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- $a The burden and epidemiology of community-acquired central nervous system infections: a multinational study / $c H. Erdem, A. Inan, E. Guven, S. Hargreaves, L. Larsen, G. Shehata, E. Pernicova, E. Khan, L. Bastakova, S. Namani, A. Harxhi, T. Roganovic, B. Lakatos, S. Uysal, OR. Sipahi, A. Crisan, E. Miftode, R. Stebel, B. Jegorovic, Z. Fehér, C. Jekkel, N. Pandak, A. Moravveji, H. Yilmaz, A. Khalifa, U. Musabak, S. Yilmaz, A. Jouhar, N. Oztoprak, X. Argemi, M. Baldeyrou, G. Bellaud, RV. Moroti, R. Hasbun, L. Salazar, R. Tekin, A. Canestri, L. Čalkić, L. Praticò, F. Yilmaz-Karadag, L. Santos, A. Pinto, F. Kaptan, P. Bossi, J. Aron, A. Duissenova, G. Shopayeva, B. Utaganov, S. Grgic, G. Ersoz, AKL. Wu, KC. Lung, A. Bruzsa, LB. Radic, H. Kahraman, M. Momen-Heravi, S. Kulzhanova, F. Rigo, M. Konkayeva, Z. Smagulova, T. Tang, P. Chan, S. Ahmetagic, H. Porobic-Jahic, F. Moradi, S. Kaya, Y. Cag, A. Bohr, C. Artuk, I. Celik, M. Amsilli, HC. Gul, A. Cascio, M. Lanzafame, M. Nassar,
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- $a Risk assessment of central nervous system (CNS) infection patients is of key importance in predicting likely pathogens. However, data are lacking on the epidemiology globally. We performed a multicenter study to understand the burden of community-acquired CNS (CA-CNS) infections between 2012 and 2014. A total of 2583 patients with CA-CNS infections were included from 37 referral centers in 20 countries. Of these, 477 (18.5%) patients survived with sequelae and 227 (8.8%) died, and 1879 (72.7%) patients were discharged with complete cure. The most frequent infecting pathogens in this study were Streptococcus pneumoniae (n = 206, 8%) and Mycobacterium tuberculosis (n = 152, 5.9%). Varicella zoster virus and Listeria were other common pathogens in the elderly. Although staphylococci and Listeria resulted in frequent infections in immunocompromised patients, cryptococci were leading pathogens in human immunodeficiency virus (HIV)-positive individuals. Among the patients with any proven etiology, 96 (8.9%) patients presented with clinical features of a chronic CNS disease. Neurosyphilis, neurobrucellosis, neuroborreliosis, and CNS tuberculosis had a predilection to present chronic courses. Listeria monocytogenes, Staphylococcus aureus, M. tuberculosis, and S. pneumoniae were the most fatal forms, while sequelae were significantly higher for herpes simplex virus type 1 (p < 0.05 for all). Tackling the high burden of CNS infections globally can only be achieved with effective pneumococcal immunization and strategies to eliminate tuberculosis, and more must be done to improve diagnostic capacity.
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- $a Inan, A $u Department of Infectious Diseases and Clinical Microbiology, Haydarpasa Numune Training and Research Hospital, Istanbul, Turkey.
- 700 1_
- $a Guven, E $u Beytepe Murat Erdi Eker State Hospital, Ankara, Turkey.
- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
- $a Moravveji, A $u Social Determinants of Health Research Center, Department of Community Medicine, Kashan University of Medical Sciences, Kashan, Iran.
- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
- $a Yilmaz, S $u Gulhane Medical Academy, Blood Bank, Clinical Microbiology Division, Ankara, Turkey.
- 700 1_
- $a Jouhar, A $u Department of Neurology, Damascus Hospital, Damascus, Syria.
- 700 1_
- $a Oztoprak, N $u Antalya Education and Research Hospital, Antalya, Turkey.
- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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