Detail
Article
Online article
FT
Medvik - BMC
  • Something wrong with this record ?

Novel patterns of left ventricular mechanical activity during experimental cardiac arrest in pigs

R. Skulec, D. Astapenko, R. Cerna Parizkova, B. Furst, M. Bilska, T. Parizek, T. Hovanec, N. Pinterova, J. Knor, J. Dudakova, A. Truhlar, V. Radochova, Z. Zadak, V. Cerny

. 2018 ; 67 (3) : 391-399. [pub] 20180312

Language English Country Czech Republic

Document type Journal Article

Persistent link   https://www.medvik.cz/link/bmc18040234

We conducted an experimental study to evaluate the presence of coordinated left ventricular mechanical myocardial activity (LVMA) in two types of experimentally induced cardiac arrest: ventricular fibrillation (VF) and pulseless electrical activity (PEA). Twenty anesthetized domestic pigs were randomized 1:1 either to induction of VF or PEA. They were left in nonresuscitated cardiac arrest until the cessation of LVMA and microcirculation. Surface ECG, presence of LVMA by transthoracic echocardiography and sublingual microcirculation were recorded. One minute after induction of cardiac arrest, LVMA was identified in all experimental animals. In the PEA group, rate of LVMA was of 106+/-12/min. In the VF group, we identified two patterns of LVMA. Six animals exhibited contractions of high frequency (VFhigh group), four of low frequency (VFlow group) (334+/-12 vs. 125+/-32/min, p<0.001). A time from cardiac arrest induction to asystole (19.2+/-7.2 vs. 7.3+/-2.2 vs. 8.3+/-5.5 min, p=0.003), cessation of LVMA (11.3+/-5.6 vs. 4.4+/-0.4 vs. 7.4+/-2.9 min, p=0.027) and cessation of microcirculation (25.3+/-12.6 vs. 13.4+/-2.4 vs. 23.2+/-8.7 min, p=0.050) was significantly longer in VFlow group than in VFhigh and PEA group, respectively. Thus, LVMA is present in both VF and PEA type of induced cardiac arrest and moreover, VF may exhibit various patterns of LVMA.

References provided by Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc18040234
003      
CZ-PrNML
005      
20191106121724.0
007      
ta
008      
181214s2018 xr d f 000 0|eng||
009      
AR
024    7_
$a 10.33549/physiolres.933716 $2 doi
035    __
$a (PubMed)29527908
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xr
100    1_
$a Škulec, Roman, $u Department of Anesthesiology and Intensive Care, Charles University in Prague, Faculty of Medicine in Hradec Kralove, University Hospital Hradec Kralove, Hradec Kralove Czech Republic; Department of Anesthesiology, Perioperative Medicine and Intensive Care, J.E. Purkinje University, Masaryk Hospital Usti nad Labem, Usti nad Labem, Czech Republic; Emergency Medical Service of the Central Bohemian Region, Kladno, Czech Republic $d 1972- $7 xx0071053
245    10
$a Novel patterns of left ventricular mechanical activity during experimental cardiac arrest in pigs / $c R. Skulec, D. Astapenko, R. Cerna Parizkova, B. Furst, M. Bilska, T. Parizek, T. Hovanec, N. Pinterova, J. Knor, J. Dudakova, A. Truhlar, V. Radochova, Z. Zadak, V. Cerny
520    9_
$a We conducted an experimental study to evaluate the presence of coordinated left ventricular mechanical myocardial activity (LVMA) in two types of experimentally induced cardiac arrest: ventricular fibrillation (VF) and pulseless electrical activity (PEA). Twenty anesthetized domestic pigs were randomized 1:1 either to induction of VF or PEA. They were left in nonresuscitated cardiac arrest until the cessation of LVMA and microcirculation. Surface ECG, presence of LVMA by transthoracic echocardiography and sublingual microcirculation were recorded. One minute after induction of cardiac arrest, LVMA was identified in all experimental animals. In the PEA group, rate of LVMA was of 106+/-12/min. In the VF group, we identified two patterns of LVMA. Six animals exhibited contractions of high frequency (VFhigh group), four of low frequency (VFlow group) (334+/-12 vs. 125+/-32/min, p<0.001). A time from cardiac arrest induction to asystole (19.2+/-7.2 vs. 7.3+/-2.2 vs. 8.3+/-5.5 min, p=0.003), cessation of LVMA (11.3+/-5.6 vs. 4.4+/-0.4 vs. 7.4+/-2.9 min, p=0.027) and cessation of microcirculation (25.3+/-12.6 vs. 13.4+/-2.4 vs. 23.2+/-8.7 min, p=0.050) was significantly longer in VFlow group than in VFhigh and PEA group, respectively. Thus, LVMA is present in both VF and PEA type of induced cardiac arrest and moreover, VF may exhibit various patterns of LVMA.
650    _2
$a zvířata $7 D000818
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a srdeční zástava $x patofyziologie $7 D006323
650    _2
$a srdeční komory $x patofyziologie $7 D006352
650    _2
$a prasata $7 D013552
650    _2
$a fibrilace komor $x patofyziologie $7 D014693
655    _2
$a časopisecké články $7 D016428
700    1_
$a Astapenko, David $7 xx0232618 $u Department of Anesthesiology and Intensive Care, Charles University in Prague, Faculty of Medicine in Hradec Kralove, University Hospital Hradec Kralove, Hradec Kralove Czech Republic
700    1_
$a Černá Pařízková, Renata, $d 1962- $7 xx0018873 $u Department of Anesthesiology and Intensive Care, Charles University in Prague, Faculty of Medicine in Hradec Kralove, University Hospital Hradec Kralove, Hradec Kralove Czech Republic
700    1_
$a Furst, B. $u Department of Anesthesiology, Albany Medical College, NY, USA
700    1_
$a Bilska, M. $u Department of Anesthesiology and Intensive Care, Charles University in Prague, Faculty of Medicine in Hradec Kralove, University Hospital Hradec Kralove, Hradec Kralove Czech Republic
700    1_
$a Pařízek, Tomáš $7 xx0241533 $u Department of Anesthesiology and Intensive Care, Charles University in Prague, Faculty of Medicine in Hradec Kralove, University Hospital Hradec Kralove, Hradec Kralove Czech Republic
700    1_
$a Hovanec, Tomáš. $7 xx0258133 $u Faculty of Medicine in Hradec Kralove, Charles University in Prague, Hradec Kralove, Czech Republic
700    1_
$a Pinterová, Nikola. $7 xx0258135 $u Faculty of Science, Charles University in Prague, Prague, Czech Republic
700    1_
$a Knor, Jiří, $d 1966- $7 xx0070804 $u Emergency Medical Service of the Central Bohemian Region, Kladno, Czech Republic; Third Medical Faculty, Charles University in Prague, Prague, Czech Republic
700    1_
$a Dudáková, Jaroslava. $7 xx0258129 $u Emergency Medical Service of the Central Bohemian Region, Kladno, Czech Republic
700    1_
$a Truhlář, Anatolij $7 xx0106452 $u Department of Anesthesiology and Intensive Care, Charles University in Prague, Faculty of Medicine in Hradec Kralove, University Hospital Hradec Kralove, Hradec Kralove Czech Republic; Hradec Kralove Region Emergency Medical Services, Hradec Kralove, Czech Republic
700    1_
$a Radochová, Věra $7 xx0258128 $u Faculty of Military Health Sciences, University of Defence, Brno, Czech Republic
700    1_
$a Zadák, Zdeněk, $d 1937- $7 nlk19990074064 $u Department of Research and Development, Charles University in Prague, Faculty of Medicinein Hradec Kralove, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic; Third Department of Internal Medicine –Metabolic Care and Gerontology, Charles University in Prague, Faculty of Medicine in Hradec Kralove, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic
700    1_
$a Černý, Vladimír, $d 1960- $7 nlk19990074192 $u Department of Anesthesiology and Intensive Care, Charles University in Prague, Faculty of Medicine in Hradec Kralove, University Hospital Hradec Kralove, Hradec Kralove Czech Republic; Department of Anesthesiology, Perioperative Medicine and Intensive Care, J.E. Purkinje University, Masaryk Hospital Usti nad Labem, Usti nad Labem, Czech Republic; Department of Research and Development, Charles University in Prague, Faculty of Medicinein Hradec Kralove, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic; Department of Anesthesia, Pain Management and Perioperative Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
773    0_
$w MED00003824 $t Physiological research $x 1802-9973 $g Roč. 67, č. 3 (2018), s. 391-399
856    41
$u https://pubmed.ncbi.nlm.nih.gov/29527908 $y Pubmed
910    __
$a ABA008 $b A 4120 $c 266 $y 4 $z 0
990    __
$a 20181214 $b ABA008
991    __
$a 20191106121955 $b ABA008
999    __
$a ok $b bmc $g 1369657 $s 1037297
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2018 $b 67 $c 3 $d 391-399 $e 20180312 $i 1802-9973 $m Physiological research $n Physiol. Res. (Print) $x MED00003824
LZP    __
$b NLK118 $a Pubmed-20181214

Find record

Citation metrics

Archiving options