• Je něco špatně v tomto záznamu ?

Positioning Europe for the EPITRANSCRIPTOMICS challenge

MF. Jantsch, A. Quattrone, M. O'Connell, M. Helm, M. Frye, M. Macias-Gonzales, M. Ohman, S. Ameres, L. Willems, F. Fuks, A. Oulas, S. Vanacova, H. Nielsen, C. Bousquet-Antonelli, Y. Motorin, JY. Roignant, N. Balatsos, A. Dinnyes, P. Baranov, V....

. 2018 ; 15 (6) : 829-831. [pub] 20180509

Jazyk angličtina Země Spojené státy americké

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc19000795

The genetic alphabet consists of the four letters: C, A, G, and T in DNA and C,A,G, and U in RNA. Triplets of these four letters jointly encode 20 different amino acids out of which proteins of all organisms are built. This system is universal and is found in all kingdoms of life. However, bases in DNA and RNA can be chemically modified. In DNA, around 10 different modifications are known, and those have been studied intensively over the past 20 years. Scientific studies on DNA modifications and proteins that recognize them gave rise to the large field of epigenetic and epigenomic research. The outcome of this intense research field is the discovery that development, ageing, and stem-cell dependent regeneration but also several diseases including cancer are largely controlled by the epigenetic state of cells. Consequently, this research has already led to the first FDA approved drugs that exploit the gained knowledge to combat disease. In recent years, the ~150 modifications found in RNA have come to the focus of intense research. Here we provide a perspective on necessary and expected developments in the fast expanding area of RNA modifications, termed epitranscriptomics.

b Oslo University Hospital Oslo Norway

b UNIVERSITA DEGLI STUDI DI TRENTO Italy

ba University of Nottingham School of Biosceinces Nottingham United Kingdom

c CEITEC Masaryk University Brno Czech Republic

c International Institute of Molecular and Cell Biology in Warsaw Poland

e IPATIMUP Porto Portugal

e University of Cambridge Cambridge United Kingdom

f Hospital Complex of Malaga Malaga Spain

f Victor Babes National Institute of Pathology Bucharest Romania

g Faculty of Biology University o Bucharest Bucharest Romania

g Stockholm University Sweden

h IMBA Institute of Molecular Biotechnology Vienna Austria

h Institute for Biological Research Sinisa Stankovic Belgrade Serbia

i Institute of Molecular Genetics and Genetic Engineering University of Belgrade Belgrade Serbia

i Molecular and Cellular Epigenetics Interdisciplinary Cluster for Applied Genoproteomics University of Liege Sart Tilman Belgium

Instituto Portugues de Oncologia do Porto Porto Portugal

Istanbul Medipol University Istanbul Turkey

j Faculty of Pharmacy University of Bratislava Slovakia

j ULB Faculty of Medicine Brussels Belgium

Johannes Gutenberg Universitat Mainz Mainz Germany

k Fundacion para la Gestion de la Investigacion Biomedica de Cadiz Cadiz Spain al Polygene AG Zürich Switzerland am Gebze Technical University Gebze Turkey

k The Cyprus Institute of Neurology and Genetics Cyprus

l University of Copenhagen Copenhagen Denmark

Lorraine University CNRS Biopole UL Lorraine France

m CNRS University of Perpignan Perpignan France

m Gebze Technical University Gebze Turkey

Medical University of Vienna Department of Cell and Developmental Biology Vienna Austria

Norwegian University of Science and Technology Department of Cancer Research and Molecular Medicine Faculty of Medicine Norwegian Trondheim Norway

o Institute of Molecular Biology Mainz Germany

o University of Dundee Centre for Gene Regulation and Expression School of Life Sciences Dundee United Kingdom

p Universite Libre de Bruxelles Gosselies Belgium

p University of Thessaly Department of Biochemistry and Biotechnology Thessaly Greece

q Biotalentum Ltd Gödöllö Hungary

q Institut de Genomique Fonctionnelle Montpellier France

r Institut de Biologie Paris Seine Pierre et Marie Curie University Institut de Biologie Paris Paris France

r University College Cork Biochemistry Department Cork Ireland

s German Cancer Research Center Heidelberg Germany

s Trinity College Dublin Trinity Biomedical Sciences Institute Dublin Ireland

t Technion Israel institute of technology Haifa Israel

t University of Kassel Kassel Germany

u Tel Aviv University Tel Aviv Israel

u Weizmann Institute of Science Rehovot Israel

v Center for Genomic Science of Milano Italy

v Institute for Advanced Bioscience Grenoble France

w Fundacion IMDEA Alimentacion Ctra de Canto Blanco Madrid Spain

w University of Latvia Riga Latvia

x Germans Trias i Pujol Research Institute Barcelona Spain

x Riga Stradins University A Kirhensteins Institute of Microbiology Riga Latvia

y National Blood Transfusion Service St Luke's Hospital Malta

y University of Edinburgh MRC Centre for Regenerative Medicine Edinburgh United Kingdom

z The Francis Crick Institute London United Kingdom

z University of Malta Centre for Molecular Medicine and Biobanking Biomedical sciences Malta

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc19000795
003      
CZ-PrNML
005      
20190115120723.0
007      
ta
008      
190107s2018 xxu f 000 0|eng||
009      
AR
024    7_
$a 10.1080/15476286.2018.1460996 $2 doi
035    __
$a (PubMed)29671387
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxu
100    1_
$a Jantsch, Michael F $u a Medical University of Vienna , Department of Cell- and Developmental Biology , Vienna , Austria.
245    10
$a Positioning Europe for the EPITRANSCRIPTOMICS challenge / $c MF. Jantsch, A. Quattrone, M. O'Connell, M. Helm, M. Frye, M. Macias-Gonzales, M. Ohman, S. Ameres, L. Willems, F. Fuks, A. Oulas, S. Vanacova, H. Nielsen, C. Bousquet-Antonelli, Y. Motorin, JY. Roignant, N. Balatsos, A. Dinnyes, P. Baranov, V. Kelly, A. Lamm, G. Rechavi, M. Pelizzola, J. Liepins, I. Holodnuka Kholodnyuk, V. Zammit, D. Ayers, F. Drablos, JA. Dahl, J. Bujnicki, C. Jeronimo, R. Almeida, M. Neagu, M. Costache, J. Bankovic, B. Banovic, J. Kyselovic, LM. Valor, S. Selbert, P. Pir, T. Demircan, V. Cowling, M. Schäfer, W. Rossmanith, D. Lafontaine, A. David, C. Carre, F. Lyko, R. Schaffrath, S. Schwartz, A. Verdel, A. Klungland, E. Purta, G. Timotijevic, F. Cardona, A. Davalos, E. Ballana, D. O Carroll, J. Ule, R. Fray,
520    9_
$a The genetic alphabet consists of the four letters: C, A, G, and T in DNA and C,A,G, and U in RNA. Triplets of these four letters jointly encode 20 different amino acids out of which proteins of all organisms are built. This system is universal and is found in all kingdoms of life. However, bases in DNA and RNA can be chemically modified. In DNA, around 10 different modifications are known, and those have been studied intensively over the past 20 years. Scientific studies on DNA modifications and proteins that recognize them gave rise to the large field of epigenetic and epigenomic research. The outcome of this intense research field is the discovery that development, ageing, and stem-cell dependent regeneration but also several diseases including cancer are largely controlled by the epigenetic state of cells. Consequently, this research has already led to the first FDA approved drugs that exploit the gained knowledge to combat disease. In recent years, the ~150 modifications found in RNA have come to the focus of intense research. Here we provide a perspective on necessary and expected developments in the fast expanding area of RNA modifications, termed epitranscriptomics.
650    12
$a DNA nádorová $x genetika $x metabolismus $7 D004273
650    12
$a epigeneze genetická $7 D044127
650    _2
$a epigenomika $x normy $7 D057890
650    _2
$a Evropa $7 D005060
650    _2
$a stanovení celkové genové exprese $x metody $x normy $7 D020869
650    12
$a regulace genové exprese u nádorů $7 D015972
650    _2
$a lidé $7 D006801
650    12
$a nádory $x genetika $x metabolismus $7 D009369
650    12
$a RNA nádorová $x genetika $x metabolismus $7 D012334
650    12
$a transkriptom $7 D059467
655    _2
$a časopisecké články $7 D016428
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Quattrone, Alessandro $u b UNIVERSITA DEGLI STUDI DI TRENTO , Italy.
700    1_
$a O'Connell, Mary $u c CEITEC, Masaryk University , Brno , Czech Republic.
700    1_
$a Helm, Mark $u d Johannes Gutenberg Universitat Mainz , Mainz , Germany.
700    1_
$a Frye, Michaela $u e University of Cambridge , Cambridge , United Kingdom.
700    1_
$a Macias-Gonzales, Manuel $u f Hospital Complex of Malaga (Virgen de la Victoria) , Malaga , Spain.
700    1_
$a Ohman, Marie $u g Stockholm University , Sweden.
700    1_
$a Ameres, Stefan $u h IMBA - Institute of Molecular Biotechnology , Vienna , Austria.
700    1_
$a Willems, Luc $u i Molecular and Cellular Epigenetics, Interdisciplinary Cluster for Applied Genoproteomics (GIGA), University of Liege , Sart Tilman , Belgium.
700    1_
$a Fuks, Francois $u j ULB-Faculty of Medicine , Brussels , Belgium.
700    1_
$a Oulas, Anastasis $u k The Cyprus Institute of Neurology & Genetics (CING) , Cyprus.
700    1_
$a Vanacova, Stepanka $u c CEITEC, Masaryk University , Brno , Czech Republic.
700    1_
$a Nielsen, Henrik $u l University of Copenhagen , Copenhagen , Denmark.
700    1_
$a Bousquet-Antonelli, Cecile $u m CNRS, University of Perpignan , Perpignan , France.
700    1_
$a Motorin, Yuri $u n Lorraine University -CNRS Biopole UL , Lorraine , France.
700    1_
$a Roignant, Jean-Yves $u o Institute of Molecular Biology , Mainz , Germany.
700    1_
$a Balatsos, Nikolaos $u p University of Thessaly , Department of Biochemistry and Biotechnology Thessaly , Greece.
700    1_
$a Dinnyes, Andras $u q Biotalentum Ltd Gödöllö , Hungary.
700    1_
$a Baranov, Pavel $u r University College Cork Biochemistry Department , Cork , Ireland.
700    1_
$a Kelly, Vincent $u s Trinity College Dublin Trinity Biomedical Sciences Institute , Dublin , Ireland.
700    1_
$a Lamm, Ayelet $u t Technion - Israel institute of technology , Haifa , Israel.
700    1_
$a Rechavi, Gideon $u u Tel Aviv University , Tel Aviv , Israel.
700    1_
$a Pelizzola, Mattia $u v Center for Genomic Science of IIT@SEMM , Milano , Italy.
700    1_
$a Liepins, Janis $u w University of Latvia , Riga , Latvia.
700    1_
$a Holodnuka Kholodnyuk, Irina $u x Riga Stradins University A.Kirhensteins Institute of Microbiology , Riga , Latvia.
700    1_
$a Zammit, Vanessa $u y National Blood Transfusion Service, St. Luke's Hospital , Malta.
700    1_
$a Ayers, Duncan $u z University of Malta Centre for Molecular Medicine and Biobanking Biomedical sciences , Malta.
700    1_
$a Drablos, Finn $u aa Norwegian University of Science and Technology Department of Cancer Research and Molecular Medicine, Faculty of Medicine Norwegian , Trondheim , Norway.
700    1_
$a Dahl, John Arne $u ab Oslo University Hospital , Oslo , Norway.
700    1_
$a Bujnicki, Janusz $u ac International Institute of Molecular and Cell Biology in Warsaw , Poland.
700    1_
$a Jeronimo, Carmen $u ad Instituto Portugues de Oncologia do Porto , Porto , Portugal.
700    1_
$a Almeida, Raquel $u ae IPATIMUP , Porto , Portugal.
700    1_
$a Neagu, Monica $u af "Victor Babes" National Institute of Pathology Bucharest , Romania.
700    1_
$a Costache, Marieta $u ag Faculty of Biology , University o Bucharest , Bucharest , Romania.
700    1_
$a Bankovic, Jasna $u ah Institute for Biological Research "Sinisa Stankovic" , Belgrade , Serbia.
700    1_
$a Banovic, Bojana $u ai Institute of Molecular Genetics and Genetic Engineering, University of Belgrade , Belgrade , Serbia.
700    1_
$a Kyselovic, Jan $u aj Faculty of Pharmacy, University of Bratislava , Slovakia.
700    1_
$a Valor, Luis Miguel $u ak Fundacion para la Gestion de la Investigacion Biomedica de Cadiz , Cadiz , Spain. al Polygene AG , Zürich , Switzerland. am Gebze Technical University , Gebze , Turkey.
700    1_
$a Selbert, Stefan $u an Istanbul Medipol University , Istanbul , Turkey.
700    1_
$a Pir, Pinar $u am Gebze Technical University , Gebze , Turkey.
700    1_
$a Demircan, Turan $u an Istanbul Medipol University , Istanbul , Turkey.
700    1_
$a Cowling, Victoria $u ao University of Dundee Centre for Gene Regulation and Expression School of Life Sciences , Dundee , United Kingdom.
700    1_
$a Schäfer, Matthias $u a Medical University of Vienna , Department of Cell- and Developmental Biology , Vienna , Austria.
700    1_
$a Rossmanith, Walter $u a Medical University of Vienna , Department of Cell- and Developmental Biology , Vienna , Austria.
700    1_
$a Lafontaine, Denis $u ap Universite Libre de Bruxelles , Gosselies , Belgium.
700    1_
$a David, Alexandre $u aq Institut de Genomique Fonctionnelle , Montpellier , France.
700    1_
$a Carre, Clement $u ar Institut de Biologie Paris Seine - Pierre et Marie Curie University Institut de Biologie Paris , Paris , France.
700    1_
$a Lyko, Frank $u as German Cancer Research Center , Heidelberg , Germany.
700    1_
$a Schaffrath, Raffael $u at University of Kassel , Kassel , Germany.
700    1_
$a Schwartz, Schraga $u au Weizmann Institute of Science , Rehovot , Israel.
700    1_
$a Verdel, Andre $u av Institute for Advanced Bioscience , Grenoble , France.
700    1_
$a Klungland, Arne $u ab Oslo University Hospital , Oslo , Norway.
700    1_
$a Purta, Elzbieta $u ad Instituto Portugues de Oncologia do Porto , Porto , Portugal.
700    1_
$a Timotijevic, Gordana $u ai Institute of Molecular Genetics and Genetic Engineering, University of Belgrade , Belgrade , Serbia.
700    1_
$a Cardona, Fernando $u f Hospital Complex of Malaga (Virgen de la Victoria) , Malaga , Spain.
700    1_
$a Davalos, Alberto $u aw Fundacion IMDEA Alimentacion Ctra . de Canto Blanco, Madrid , Spain.
700    1_
$a Ballana, Ester $u ax Germans Trias i Pujol Research Institute , Barcelona , Spain.
700    1_
$a O Carroll, Donal $u ay University of Edinburgh MRC Centre for Regenerative Medicine , Edinburgh , United Kingdom.
700    1_
$a Ule, Jernej $u az The Francis Crick Institute , London , United Kingdom.
700    1_
$a Fray, Rupert $u ba University of Nottingham School of Biosceinces , Nottingham , United Kingdom.
773    0_
$w MED00181077 $t RNA biology $x 1555-8584 $g Roč. 15, č. 6 (2018), s. 829-831
856    41
$u https://pubmed.ncbi.nlm.nih.gov/29671387 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20190107 $b ABA008
991    __
$a 20190115120933 $b ABA008
999    __
$a ok $b bmc $g 1363924 $s 1038918
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2018 $b 15 $c 6 $d 829-831 $e 20180509 $i 1555-8584 $m RNA biology $n RNA Biol $x MED00181077
LZP    __
$a Pubmed-20190107
Zpět

Najít záznam

Citační ukazatele

Možnosti archivace