-
Je něco špatně v tomto záznamu ?
Androst-5-ene-3β,7α/β,17β-triols, their plasma levels and dependence on the hypothalamic-pituitary-adrenal axis
L. Stárka, M. Hill, L. Kolatorova, M. Dušková,
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, práce podpořená grantem
- MeSH
- androsteron krev MeSH
- dospělí MeSH
- hypothalamus metabolismus MeSH
- lidé MeSH
- systém hypofýza - nadledviny metabolismus MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
Androst-5-ene-triols are metabolites of dehydroepiandrosterone, the most abundant steroid hormone in human circulation. Many observations in rodents have demonstrated the anti-inflammatory and immune modulating activity of 7β-hydroxy-androst-5-enes, and on the basis of these experiments androst-5-ene-3β,7β,17β-triol is considered as a potential agent in the treatment of autoimmune diseases. In contrast to the fairly abundant information on the levels and effects of androst-5-ene-triols in experimental animals and of their the pharmacological perspective, little is known about androst-5-ene-3β,7α/β,17β-triols circulating in human blood, their regulation by the hypothalamo-pituitary-adrenal axis, or their daily concentration variability. Here we provide some data on androst-5-ene-3β,7α/β,17β-triol concentrations under various conditions in men and women.
Citace poskytuje Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc19000897
- 003
- CZ-PrNML
- 005
- 20190122114054.0
- 007
- ta
- 008
- 190107s2018 xxu f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1016/j.steroids.2018.02.005 $2 doi
- 035 __
- $a (PubMed)29477344
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xxu
- 100 1_
- $a Stárka, Luboslav $u Institute of Endocrinology, Národní 8, 11694 Prague 1, Czech Republic. Electronic address: lstarka@endo.cz.
- 245 10
- $a Androst-5-ene-3β,7α/β,17β-triols, their plasma levels and dependence on the hypothalamic-pituitary-adrenal axis / $c L. Stárka, M. Hill, L. Kolatorova, M. Dušková,
- 520 9_
- $a Androst-5-ene-triols are metabolites of dehydroepiandrosterone, the most abundant steroid hormone in human circulation. Many observations in rodents have demonstrated the anti-inflammatory and immune modulating activity of 7β-hydroxy-androst-5-enes, and on the basis of these experiments androst-5-ene-3β,7β,17β-triol is considered as a potential agent in the treatment of autoimmune diseases. In contrast to the fairly abundant information on the levels and effects of androst-5-ene-triols in experimental animals and of their the pharmacological perspective, little is known about androst-5-ene-3β,7α/β,17β-triols circulating in human blood, their regulation by the hypothalamo-pituitary-adrenal axis, or their daily concentration variability. Here we provide some data on androst-5-ene-3β,7α/β,17β-triol concentrations under various conditions in men and women.
- 650 _2
- $a dospělí $7 D000328
- 650 _2
- $a androsteron $x krev $7 D000738
- 650 _2
- $a ženské pohlaví $7 D005260
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a hypothalamus $x metabolismus $7 D007031
- 650 _2
- $a mužské pohlaví $7 D008297
- 650 _2
- $a systém hypofýza - nadledviny $x metabolismus $7 D010913
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a práce podpořená grantem $7 D013485
- 700 1_
- $a Hill, Martin $u Institute of Endocrinology, Národní 8, 11694 Prague 1, Czech Republic. Electronic address: mhill@endo.cz.
- 700 1_
- $a Kolatorova, Lucie $u Institute of Endocrinology, Národní 8, 11694 Prague 1, Czech Republic. Electronic address: lkolatorova@endo.cz.
- 700 1_
- $a Dušková, Michaela $u Institute of Endocrinology, Národní 8, 11694 Prague 1, Czech Republic. Electronic address: mduskova@endo.cz.
- 773 0_
- $w MED00004438 $t Steroids $x 1878-5867 $g Roč. 134, č. - (2018), s. 88-95
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/29477344 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y a $z 0
- 990 __
- $a 20190107 $b ABA008
- 991 __
- $a 20190122114313 $b ABA008
- 999 __
- $a ok $b bmc $g 1363948 $s 1039020
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2018 $b 134 $c - $d 88-95 $e 20180223 $i 1878-5867 $m Steroids $n Steroids $x MED00004438
- LZP __
- $a Pubmed-20190107
