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Determinants of occurrence and survival after sudden cardiac arrest-A European perspective: The ESCAPE-NET project

JP. Empana, MT. Blom, BW. Bӧttiger, N. Dagres, JM. Dekker, G. Gislason, X. Jouven, T. Meitinger, G. Ristagno, PJ. Schwartz, M. Jonsson, J. Tfelt-Hansen, A. Truhlar, HL. Tan, . ,

. 2018 ; 124 (-) : 7-13. [pub] 20171212

Language English Country Ireland

Document type Journal Article, Observational Study, Research Support, Non-U.S. Gov't

Persistent link   https://www.medvik.cz/link/bmc19001034

AIMS: The ESCAPE-NET project ("European Sudden Cardiac Arrest network- towards Prevention, Education and New Effective Treatments") aims to study: (1) risk factors and mechanisms for the occurrence of sudden cardiac arrest (SCA) in the population, and (2) risk factors and treatment strategies for survival after SCA on a European scale. METHODS: This is an Horizon2020 funded program of the European Union, performed by a European public-private consortium of 16 partners across 10 EU countries. There are 11 deep-phenotyped SCA cohorts for the study of risk factors and treatment strategies for survival after SCA, and 5 deep-phenotyped observational prospective population cohorts for the study of risk factors for occurrence of SCA. Personalized risk scores for predicting SCA onset and for predicting survival after SCA will be derived and validated. RESULTS: The 11 clinical studies with SCA cases comprise 85,790 SCA cases; the 5 observational prospective population cohorts include 53,060 subjects. A total of 15,000 SCA samples will be genotyped for common and rare variants at the Helmholtz Zentrum München (Germany) using the Illumina Global Screening Array which contains > 770,000 SNPs, and after imputation, a database of an estimated > 9 million variants will be available for genome wide association studies. Standardization of risk factors definition and outcomes is ongoing. An Executive Committee has been created along with a Collaboration Policy document. CONCLUSION: ESCAPE-NET will complement ongoing efforts on SCA outside Europe and within Europe including the EuReCa project.

References provided by Crossref.org

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$a Empana, Jean-Philippe $u Université Paris Descartes, INSERM UMRS-970, Paris Cardiovascular Research Centre, Paris, France.
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$a AIMS: The ESCAPE-NET project ("European Sudden Cardiac Arrest network- towards Prevention, Education and New Effective Treatments") aims to study: (1) risk factors and mechanisms for the occurrence of sudden cardiac arrest (SCA) in the population, and (2) risk factors and treatment strategies for survival after SCA on a European scale. METHODS: This is an Horizon2020 funded program of the European Union, performed by a European public-private consortium of 16 partners across 10 EU countries. There are 11 deep-phenotyped SCA cohorts for the study of risk factors and treatment strategies for survival after SCA, and 5 deep-phenotyped observational prospective population cohorts for the study of risk factors for occurrence of SCA. Personalized risk scores for predicting SCA onset and for predicting survival after SCA will be derived and validated. RESULTS: The 11 clinical studies with SCA cases comprise 85,790 SCA cases; the 5 observational prospective population cohorts include 53,060 subjects. A total of 15,000 SCA samples will be genotyped for common and rare variants at the Helmholtz Zentrum München (Germany) using the Illumina Global Screening Array which contains > 770,000 SNPs, and after imputation, a database of an estimated > 9 million variants will be available for genome wide association studies. Standardization of risk factors definition and outcomes is ongoing. An Executive Committee has been created along with a Collaboration Policy document. CONCLUSION: ESCAPE-NET will complement ongoing efforts on SCA outside Europe and within Europe including the EuReCa project.
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$a Blom, Marieke T $u Department of Cardiology, Heart Center, Academic Medical Center, Amsterdam, The Netherlands.
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$a Bӧttiger, Bernd W $u European Resuscitation Council, Brussels, Belgium; Department of Anesthesiology and Intensive Care Medicine, University Hospital of Cologne, Cologne, Germany.
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$a Dagres, Nikolaos $u European Heart Rhythm Association, representing the European Society of Cardiology, Sophia Antipolis, France.
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$a Dekker, Jacqueline M $u VU University Medical Center, Amsterdam, The Netherlands.
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$a Gislason, Gunnar $u Department of Cardiology, Copenhagen University Hospital, Gentofte, Denmark and Danish Heart Foundation.
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$a Jouven, Xavier $u Université Paris Descartes, INSERM UMRS-970, Paris Cardiovascular Research Centre, Paris, France.
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$a Meitinger, Thomas $u Department of Human Genetics, Helmholtz Center, Munich, Germany.
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$a Ristagno, Giuseppe $u IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy; Italian Resuscitation Council, Bologna, Italy.
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$a Schwartz, Peter J $u IRCCS Istituto Auxologico Italiano, Reference Network for Rare and Low Prevalence Complexe Diseases of the Heart (ERN GUARD-HEART), Italy.
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$a Jonsson, Martin $u Center for Resuscitation Science, Department of Medicine, Solna, Karolinska Institute, Stockholm, Sweden.
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$a Tfelt-Hansen, Jacob $u The Department of Cardiology, The Heart Centre, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark and Department of Forensic Medicine, Faculty of Medical Sciences, University of Copenhagen, Denmark and Reference Network for Rare and Low Prevalence Complexe Diseases of the Heart (ERN GUARD-HEART).
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$a Truhlar, Anatolij $u Emergency Medical Services of the Hradec Kralove Region, Czech Republic.
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$a Tan, Hanno L $u Department of Cardiology, Heart Center, Academic Medical Center, Amsterdam, The Netherlands. Electronic address: h.l.tan@amc.nl.
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