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Je něco špatně v tomto záznamu ?
Lack of association between ENAM gene polymorphism and dental caries in primary and permanent teeth in Czech children
P. Borilova Linhartova, T. Deissova, K. Musilova, L. Zackova, M. Kukletova, L. Kukla, L. Izakovicova Holla,
Jazyk angličtina Země Německo
Typ dokumentu časopisecké články
Grantová podpora
NV17-30439A
MZ0
CEP - Centrální evidence projektů
Digitální knihovna NLK
Plný text - Článek
NLK
ProQuest Central
od 1997-03-01 do Před 1 rokem
Health & Medicine (ProQuest)
od 1997-03-01 do Před 1 rokem
Public Health Database (ProQuest)
od 1997-03-01 do Před 1 rokem
- MeSH
- dentice trvalá MeSH
- dítě MeSH
- DMF Index MeSH
- extracelulární matrix - proteiny genetika MeSH
- genotyp MeSH
- jednonukleotidový polymorfismus * MeSH
- kojenec MeSH
- lidé MeSH
- mladiství MeSH
- předškolní dítě MeSH
- zubní kaz epidemiologie genetika MeSH
- zuby mléčné MeSH
- Check Tag
- dítě MeSH
- kojenec MeSH
- lidé MeSH
- mladiství MeSH
- mužské pohlaví MeSH
- předškolní dítě MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Geografické názvy
- Česká republika epidemiologie MeSH
OBJECTIVES: The enamelin gene (ENAM) polymorphism (rs12640848) was recently associated with dental caries in primary teeth in Polish children. The aims of the present study were to prove this association in primary dentition and to find a possible effect of this variant on caries development in permanent dentition in Czech children. MATERIALS AND METHODS: This study comprised 905 Czech children. Totally, 187 children aged 2-6 years with primary dentition [78 healthy subjects (with decayed/missing/filled teeth, dmft = 0) and 109 patients with early childhood caries (ECC; dmft ≥ 1)] were included in this case-control study. In addition, 177 subjects aged 13-15 years without caries (DMFT = 0) and 541 children with dental caries (DMFT ≥ 1) in permanent dentition were selected from the ELSPAC study. Genotype determination of the ENAM polymorphism (rs12640848) was based on the TaqMan method. RESULTS: No significant differences in the allele or genotype frequencies between the caries-free children and those affected by dental caries were observed in both primary and permanent dentitions. CONCLUSIONS: Lack of association between the ENAM polymorphism (rs12640848) and dental caries in Czech children was detected. CLINICAL RELEVANCE: Although ENAM is considered as a candidate gene for dental caries, the presence of the ENAM variant (rs12640848) cannot be used as a risk factor of this multifactorial disease in the Czech population.
Citace poskytuje Crossref.org
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- $a Borilova Linhartova, Petra $u Clinic of Stomatology, Institution Shared with St. Anne's Faculty Hospital, Faculty of Medicine, Masaryk University, Pekarska 664/53, 60200, Brno, Czech Republic. Department of Pathophysiology, Faculty of Medicine, Masaryk University, Kamenice 5, 62500, Brno, Czech Republic.
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- $a Lack of association between ENAM gene polymorphism and dental caries in primary and permanent teeth in Czech children / $c P. Borilova Linhartova, T. Deissova, K. Musilova, L. Zackova, M. Kukletova, L. Kukla, L. Izakovicova Holla,
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- $a OBJECTIVES: The enamelin gene (ENAM) polymorphism (rs12640848) was recently associated with dental caries in primary teeth in Polish children. The aims of the present study were to prove this association in primary dentition and to find a possible effect of this variant on caries development in permanent dentition in Czech children. MATERIALS AND METHODS: This study comprised 905 Czech children. Totally, 187 children aged 2-6 years with primary dentition [78 healthy subjects (with decayed/missing/filled teeth, dmft = 0) and 109 patients with early childhood caries (ECC; dmft ≥ 1)] were included in this case-control study. In addition, 177 subjects aged 13-15 years without caries (DMFT = 0) and 541 children with dental caries (DMFT ≥ 1) in permanent dentition were selected from the ELSPAC study. Genotype determination of the ENAM polymorphism (rs12640848) was based on the TaqMan method. RESULTS: No significant differences in the allele or genotype frequencies between the caries-free children and those affected by dental caries were observed in both primary and permanent dentitions. CONCLUSIONS: Lack of association between the ENAM polymorphism (rs12640848) and dental caries in Czech children was detected. CLINICAL RELEVANCE: Although ENAM is considered as a candidate gene for dental caries, the presence of the ENAM variant (rs12640848) cannot be used as a risk factor of this multifactorial disease in the Czech population.
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