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Tungsten (VI) based "molecular puzzle" photoluminescent nanoparticles easily covered with biocompatible natural polysaccharides via direct chelation
V. Lobaz, M. Hladik, M. Steinhart, A. Paruzel, P. Černoch, J. Pánek, M. Vetrík, D. Jirák, M. Jirátová, O. Pop-Georgievski, M. Šlouf, S. Garcia-Argote, G. Pieters, E. Doris, M. Hrubý,
Language English Country United States
Document type Journal Article
Grant support
NV15-25781A
MZ0
CEP Register
- MeSH
- Biocompatible Materials chemistry MeSH
- Hep G2 Cells MeSH
- Endocytosis physiology MeSH
- Microscopy, Confocal MeSH
- Humans MeSH
- Luminescence * MeSH
- Nanoparticles administration & dosage chemistry radiation effects MeSH
- Polysaccharides chemistry MeSH
- Terbium chemistry MeSH
- Tungsten chemistry MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
Multimodal probes, which can be simultaneously visualized by multiple imaging modalities, enable the cellular uptake, intracellular fate, biodistribution and elimination to be tracked in organisms. In this study, we report the synthesis of crystalline WO3 and CaWO4 doped with Eu3+ or Tb3+ nanoparticles (size range of 10-160 nm) coated with polysaccharides, and these nanoparticles constitute a versatile easy-to-construct modular toolbox for multimodal imaging. The particles adsorb significant amounts of polysaccharides from the solution, providing biocompatibility and may serve as a platform for labeling. For WO3, the sorption is reversible. However, on CaWO4, stable coating is formed. CaWO4/Tb3+ coated with chemisorbed dextrin, mannan, guar gum and sodium alginate successfully underwent endocytosis with HepG2 cells and was visualized using confocal microscopy.
Institute for Clinical and Experimental Medicine Vídeňská str 1958 9 140 21 Prague 4 Czech Republic
Institute of Macromolecular Chemistry AS CR Heyrovsky Sq 1888 2 162 06 Prague 6 Czech Republic
References provided by Crossref.org
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