• Je něco špatně v tomto záznamu ?

Functional Evolution of Subolesin/Akirin

S. Artigas-Jerónimo, M. Villar, A. Cabezas-Cruz, JJ. Valdés, A. Estrada-Peña, P. Alberdi, J. de la Fuente,

. 2018 ; 9 (-) : 1612. [pub] 20181113

Jazyk angličtina Země Švýcarsko

Typ dokumentu časopisecké články, přehledy

Perzistentní odkaz   https://www.medvik.cz/link/bmc19001448

The Subolesin/Akirin constitutes a good model for the study of functional evolution because these proteins have been conserved throughout the metazoan and play a role in the regulation of different biological processes. Here, we investigated the evolutionary history of Subolesin/Akirin with recent results on their structure, protein-protein interactions and function in different species to provide insights into the functional evolution of these regulatory proteins, and their potential as vaccine antigens for the control of ectoparasite infestations and pathogen infection. The results suggest that Subolesin/Akirin evolved conserving not only its sequence and structure, but also its function and role in cell interactome and regulome in response to pathogen infection and other biological processes. This functional conservation provides a platform for further characterization of the function of these regulatory proteins, and how their evolution can meet species-specific demands. Furthermore, the conserved functional evolution of Subolesin/Akirin correlates with the protective capacity shown by these proteins in vaccine formulations for the control of different arthropod and pathogen species. These results encourage further research to characterize the structure and function of these proteins, and to develop new vaccine formulations by combining Subolesin/Akirin with interacting proteins for the control of multiple ectoparasite infestations and pathogen infection.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc19001448
003      
CZ-PrNML
005      
20190107105726.0
007      
ta
008      
190107s2018 sz f 000 0|eng||
024    7_
$a 10.3389/fphys.2018.01612 $2 doi
035    __
$a (PubMed)30542290
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a sz
100    1_
$a Artigas-Jerónimo, Sara $u SaBio, Instituto de Investigación en Recursos Cinegéticos (IREC), CSIC, Universidad de Castilla-La Mancha (UCLM), Junta de Comunidades de Castilla - La Mancha (JCCM), Ciudad Real, Spain.
245    10
$a Functional Evolution of Subolesin/Akirin / $c S. Artigas-Jerónimo, M. Villar, A. Cabezas-Cruz, JJ. Valdés, A. Estrada-Peña, P. Alberdi, J. de la Fuente,
520    9_
$a The Subolesin/Akirin constitutes a good model for the study of functional evolution because these proteins have been conserved throughout the metazoan and play a role in the regulation of different biological processes. Here, we investigated the evolutionary history of Subolesin/Akirin with recent results on their structure, protein-protein interactions and function in different species to provide insights into the functional evolution of these regulatory proteins, and their potential as vaccine antigens for the control of ectoparasite infestations and pathogen infection. The results suggest that Subolesin/Akirin evolved conserving not only its sequence and structure, but also its function and role in cell interactome and regulome in response to pathogen infection and other biological processes. This functional conservation provides a platform for further characterization of the function of these regulatory proteins, and how their evolution can meet species-specific demands. Furthermore, the conserved functional evolution of Subolesin/Akirin correlates with the protective capacity shown by these proteins in vaccine formulations for the control of different arthropod and pathogen species. These results encourage further research to characterize the structure and function of these proteins, and to develop new vaccine formulations by combining Subolesin/Akirin with interacting proteins for the control of multiple ectoparasite infestations and pathogen infection.
655    _2
$a časopisecké články $7 D016428
655    _2
$a přehledy $7 D016454
700    1_
$a Villar, Margarita $u SaBio, Instituto de Investigación en Recursos Cinegéticos (IREC), CSIC, Universidad de Castilla-La Mancha (UCLM), Junta de Comunidades de Castilla - La Mancha (JCCM), Ciudad Real, Spain.
700    1_
$a Cabezas-Cruz, Alejandro $u UMR BIPAR, INRA, ANSES, Ecole Nationale Vétérinaire d'Alfort, Université Paris-Est, Paris, France.
700    1_
$a Valdés, James J $u Faculty of Science, University of South Bohemia, České Budějovice, Czechia. Institute of Parasitology, Biology Centre, Czech Academy of Sciences, České Budějovice, Czechia. Department of Virology, Veterinary Research Institute, Brno, Czechia.
700    1_
$a Estrada-Peña, Agustín $u Facultad de Veterinaria, Universidad de Zaragoza, Zaragoza, Spain.
700    1_
$a Alberdi, Pilar $u SaBio, Instituto de Investigación en Recursos Cinegéticos (IREC), CSIC, Universidad de Castilla-La Mancha (UCLM), Junta de Comunidades de Castilla - La Mancha (JCCM), Ciudad Real, Spain.
700    1_
$a de la Fuente, José $u SaBio, Instituto de Investigación en Recursos Cinegéticos (IREC), CSIC, Universidad de Castilla-La Mancha (UCLM), Junta de Comunidades de Castilla - La Mancha (JCCM), Ciudad Real, Spain. Department of Veterinary Pathobiology, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, OK, United States.
773    0_
$w MED00174601 $t Front Physiol $x 1664-042X $g Roč. 9, č. - (2018), s. 1612
856    41
$u https://pubmed.ncbi.nlm.nih.gov/30542290 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a
990    __
$a 20190107 $b ABA008
999    __
$a ind $b bmc $g 1365280 $s 1039571
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2018 $b 9 $c - $d 1612 $e 20181113 $i 1664-042X $m Frontiers in physiology $n Front. physiol. $x MED00174601
LZP    __
$a Pubmed-20190107

Najít záznam

Citační ukazatele

    Možnosti archivace