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Endothelin and diabetic complications: a brain-centric view
W. Li, Y. Abdul, R. Ward, A. Ergul
Language English Country Czech Republic
Document type Journal Article, Review
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- MeSH
- Endothelin A Receptor Antagonists administration & dosage metabolism MeSH
- Endothelin B Receptor Antagonists administration & dosage metabolism MeSH
- Endothelins agonists antagonists & inhibitors metabolism MeSH
- Diabetes Complications drug therapy metabolism MeSH
- Humans MeSH
- Brain drug effects metabolism MeSH
- Cerebrovascular Circulation drug effects physiology MeSH
- Receptor, Endothelin A metabolism MeSH
- Receptor, Endothelin B metabolism MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
The global epidemic of diabetes is of significant concern. Diabetes associated vascular disease signifies the principal cause of morbidity and mortality in diabetic patients. It is also the most rapidly increasing risk factor for cognitive impairment, a silent disease that causes loss of creativity, productivity, and quality of life. Small vessel disease in the cerebral vasculature plays a major role in the pathogenesis of cognitive impairment in diabetes. Endothelin system, including endothelin-1 (ET-1) and the receptors (ET(A) and ET(B)), is a likely candidate that may be involved in many aspects of the diabetes cerebrovascular disease. In this review, we took a brain-centric approach and discussed the role of the ET system in cerebrovascular and cognitive dysfunction in diabetes.
Charlie Norwood Veterans Affairs Medical Center Augusta Georgia USA
Department of Neuroscience and Regenerative Medicine Augusta University Augusta Georgia USA
Department of Physiology Augusta University Augusta Georgia USA
References provided by Crossref.org
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