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Glycosylation in human colorectal mucosa during tumor development studied by lectins
Z. Kolár, G. Altavilla,
Jazyk angličtina Země Česko
Typ dokumentu časopisecké články
Odkazy
PubMed
2530809
Knihovny.cz E-zdroje
- MeSH
- glykosylace MeSH
- histocytochemie MeSH
- kolon metabolismus patologie MeSH
- lidé MeSH
- nádory tračníku metabolismus patologie MeSH
- receptory mitogenů metabolismus MeSH
- rektum metabolismus patologie MeSH
- střevní sliznice metabolismus patologie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
The panel of six lectins was used for demonstration of glycosylative changes in the hyperplastic, adenomatous and carcinomatous mucosa of large bowel. The obtained results were rather heterogeneous with regard to lectin binding capacity in the single cases but they proved a certain uniformity of changes inside every tested group. These changes cohered with decrease of capability dysplastic and neoplastic cells to produce of normal goblets and with loss of cell polarity. Possible causes of these alterations are discussed.
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- $a The panel of six lectins was used for demonstration of glycosylative changes in the hyperplastic, adenomatous and carcinomatous mucosa of large bowel. The obtained results were rather heterogeneous with regard to lectin binding capacity in the single cases but they proved a certain uniformity of changes inside every tested group. These changes cohered with decrease of capability dysplastic and neoplastic cells to produce of normal goblets and with loss of cell polarity. Possible causes of these alterations are discussed.
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