• Something wrong with this record ?

Selective prebiotic conversion of pyrimidine and purine anhydronucleosides into Watson-Crick base-pairing arabino-furanosyl nucleosides in water

SJ. Roberts, R. Szabla, ZR. Todd, S. Stairs, DK. Bučar, J. Šponer, DD. Sasselov, MW. Powner,

. 2018 ; 9 (1) : 4073. [pub] 20181004

Language English Country England, Great Britain

Document type Journal Article, Research Support, Non-U.S. Gov't

Persistent link   https://www.medvik.cz/link/bmc19012299

Prebiotic nucleotide synthesis is crucial to understanding the origins of life on Earth. There are numerous candidates for life's first nucleic acid, however, currently no prebiotic method to selectively and concurrently synthesise the canonical Watson-Crick base-pairing pyrimidine (C, U) and purine (A, G) nucleosides exists for any genetic polymer. Here, we demonstrate the divergent prebiotic synthesis of arabinonucleic acid (ANA) nucleosides. The complete set of canonical nucleosides is delivered from one reaction sequence, with regiospecific glycosidation and complete furanosyl selectivity. We observe photochemical 8-mercaptopurine reduction is efficient for the canonical purines (A, G), but not the non-canonical purine inosine (I). Our results demonstrate that synthesis of ANA may have been facile under conditions that comply with plausible geochemical environments on early Earth and, given that ANA is capable of encoding RNA/DNA compatible information and evolving to yield catalytic ANA-zymes, ANA may have played a critical role during the origins of life.

References provided by Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc19012299
003      
CZ-PrNML
005      
20190405092822.0
007      
ta
008      
190405s2018 enk f 000 0|eng||
009      
AR
024    7_
$a 10.1038/s41467-018-06374-z $2 doi
035    __
$a (PubMed)30287815
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a enk
100    1_
$a Roberts, Samuel J $u Department of Chemistry, University College London, 20 Gordon Street, London, WC1H 0AJ, UK.
245    10
$a Selective prebiotic conversion of pyrimidine and purine anhydronucleosides into Watson-Crick base-pairing arabino-furanosyl nucleosides in water / $c SJ. Roberts, R. Szabla, ZR. Todd, S. Stairs, DK. Bučar, J. Šponer, DD. Sasselov, MW. Powner,
520    9_
$a Prebiotic nucleotide synthesis is crucial to understanding the origins of life on Earth. There are numerous candidates for life's first nucleic acid, however, currently no prebiotic method to selectively and concurrently synthesise the canonical Watson-Crick base-pairing pyrimidine (C, U) and purine (A, G) nucleosides exists for any genetic polymer. Here, we demonstrate the divergent prebiotic synthesis of arabinonucleic acid (ANA) nucleosides. The complete set of canonical nucleosides is delivered from one reaction sequence, with regiospecific glycosidation and complete furanosyl selectivity. We observe photochemical 8-mercaptopurine reduction is efficient for the canonical purines (A, G), but not the non-canonical purine inosine (I). Our results demonstrate that synthesis of ANA may have been facile under conditions that comply with plausible geochemical environments on early Earth and, given that ANA is capable of encoding RNA/DNA compatible information and evolving to yield catalytic ANA-zymes, ANA may have played a critical role during the origins of life.
650    _2
$a arabinonukleosidy $x biosyntéza $7 D001087
650    _2
$a merkaptopurin $7 D015122
650    12
$a původ života $7 D000069497
650    _2
$a oxidace-redukce $7 D010084
650    _2
$a fotochemické procesy $7 D055668
655    _2
$a časopisecké články $7 D016428
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Szabla, Rafał $u Institute of Physics, Polish Academy of Sciences, Al. Lotników 32/46, PL-02668, Warsaw, Poland. Institute of Biophysics of the Czech Academy of Sciences, Královopolská 135, 61265, Brno, Czech Republic.
700    1_
$a Todd, Zoe R $u Harvard-Smithsonian Center for Astrophysics, Department of Astronomy, Harvard University, 60 Garden Street, Cambridge, MA, 02138, USA.
700    1_
$a Stairs, Shaun $u Department of Chemistry, University College London, 20 Gordon Street, London, WC1H 0AJ, UK.
700    1_
$a Bučar, Dejan-Krešimir $u Department of Chemistry, University College London, 20 Gordon Street, London, WC1H 0AJ, UK.
700    1_
$a Šponer, Jiří $u Institute of Biophysics of the Czech Academy of Sciences, Královopolská 135, 61265, Brno, Czech Republic.
700    1_
$a Sasselov, Dimitar D $u Harvard-Smithsonian Center for Astrophysics, Department of Astronomy, Harvard University, 60 Garden Street, Cambridge, MA, 02138, USA.
700    1_
$a Powner, Matthew W $u Department of Chemistry, University College London, 20 Gordon Street, London, WC1H 0AJ, UK. matthew.powner@ucl.ac.uk.
773    0_
$w MED00184850 $t Nature communications $x 2041-1723 $g Roč. 9, č. 1 (2018), s. 4073
856    41
$u https://pubmed.ncbi.nlm.nih.gov/30287815 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20190405 $b ABA008
991    __
$a 20190405092831 $b ABA008
999    __
$a ok $b bmc $g 1391609 $s 1050604
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2018 $b 9 $c 1 $d 4073 $e 20181004 $i 2041-1723 $m Nature communications $n Nat Commun $x MED00184850
LZP    __
$a Pubmed-20190405

Find record

Citation metrics

Archiving options