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Peripapillary microcirculation in Leber hereditary optic neuropathy
B. Kousal, H. Kolarova, M. Meliska, J. Bydzovsky, P. Diblik, J. Kulhanek, M. Votruba, T. Honzik, P. Liskova,
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu srovnávací studie, časopisecké články, pozorovací studie
Grantová podpora
NV16-32341A
MZ0
CEP - Centrální evidence projektů
Digitální knihovna NLK
Plný text - Článek
NLK
Free Medical Journals
od 2008 do Před 1 rokem
Medline Complete (EBSCOhost)
od 2008-02-01 do Před 1 rokem
Wiley Free Content
od 2008 do Před 1 rokem
PubMed
30259673
DOI
10.1111/aos.13817
Knihovny.cz E-zdroje
- MeSH
- discus nervi optici krevní zásobení diagnostické zobrazování MeSH
- dítě MeSH
- dospělí MeSH
- fluoresceinová angiografie metody MeSH
- fundus oculi MeSH
- Leberova atrofie zrakového nervu diagnóza patofyziologie MeSH
- lidé MeSH
- mikrocévy diagnostické zobrazování MeSH
- mikrocirkulace fyziologie MeSH
- mladiství MeSH
- mladý dospělý MeSH
- nervová vlákna patologie MeSH
- optická koherentní tomografie metody MeSH
- prospektivní studie MeSH
- retinální cévy diagnostické zobrazování patofyziologie MeSH
- retinální gangliové buňky patologie MeSH
- zraková ostrost * MeSH
- zraková pole MeSH
- Check Tag
- dítě MeSH
- dospělí MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- pozorovací studie MeSH
- srovnávací studie MeSH
PURPOSE: In this prospective observational comparative case series, we aimed to study the peripapillary capillary network with spectral-domain optical coherence tomography angiography (OCT-A) in Leber hereditary optic neuropathy (LHON). METHODS: Twelve eyes of six individuals, of these three males (five eyes) after clinical onset of visual impairment were imaged by OCT-A with scans centred on optic discs. Control group consisted of 6 eyes with no visual impairment. RESULTS: The three affected individuals lost vision 6 years (at age 22 years), 2 years and 3 months (at age 26 years) and 1 year and 2 months (at age 30 years) prior to OCT-A examination. All five affected eyes had alterations in density of the radial peripapillary microvascular network at the level of retinal nerve fibre layer, including an eye of a patient treated with idebenone that underwent almost full recovery (best corrected visual acuity 0.87). Interestingly, the other eye showed normal ocular findings 14 months after onset. Results of OCT-A examination in this eye were unfortunately inconclusive due to a delineation error. At the level of the ganglion cell layer differences could be also noted, but only in two severely affected individuals. There were no differences between unaffected mutation carriers and control eyes. CONCLUSION: Optical coherence tomography angiography scans confirmed that the peripapillary microvascular network is highly abnormal in eyes manifesting visual impairment due to LHON. These findings support the hypothesis that microangiopathy contributes to the development of vision loss in this mitochondrial disorder.
Citace poskytuje Crossref.org
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- $a Kousal, Bohdan $u Department of Ophthalmology, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic. Department of Paediatrics and Adolescent Medicine, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic.
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