Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

Changing the threshold-Signals and mechanisms of mast cell priming

I. Halova, E. Rönnberg, L. Draberova, H. Vliagoftis, GP. Nilsson, P. Draber,

. 2018 ; 282 (1) : 73-86.

Jazyk angličtina Země Anglie, Velká Británie

Typ dokumentu časopisecké články, práce podpořená grantem, přehledy

Perzistentní odkaz   https://www.medvik.cz/link/bmc19012844

Mast cells play a key role in allergy and other inflammatory diseases involving engagement of multivalent antigen with IgE bound to high-affinity IgE receptors (FcεRIs). Aggregation of FcεRIs on mast cells initiates a cascade of signaling events that eventually lead to degranulation, secretion of leukotrienes and prostaglandins, and cytokine and chemokine production contributing to the inflammatory response. Exposure to pro-inflammatory cytokines, chemokines, bacterial and viral products, as well as some other biological products and drugs, induces mast cell transition from the basal state into a primed one, which leads to enhanced response to IgE-antigen complexes. Mast cell priming changes the threshold for antigen-mediated activation by various mechanisms, depending on the priming agent used, which alone usually do not induce mast cell degranulation. In this review, we describe the priming processes induced in mast cells by various cytokines (stem cell factor, interleukins-4, -6 and -33), chemokines, other agents acting through G protein-coupled receptors (adenosine, prostaglandin E2 , sphingosine-1-phosphate, and β-2-adrenergic receptor agonists), toll-like receptors, and various drugs affecting the cytoskeleton. We will review the current knowledge about the molecular mechanisms behind priming of mast cells leading to degranulation and cytokine production and discuss the biological effects of mast cell priming induced by several cytokines.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc19012844
003      
CZ-PrNML
005      
20190412092422.0
007      
ta
008      
190405s2018 enk f 000 0|eng||
009      
AR
024    7_
$a 10.1111/imr.12625 $2 doi
035    __
$a (PubMed)29431203
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a enk
100    1_
$a Halova, Ivana $u Department of Signal Transduction, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic.
245    10
$a Changing the threshold-Signals and mechanisms of mast cell priming / $c I. Halova, E. Rönnberg, L. Draberova, H. Vliagoftis, GP. Nilsson, P. Draber,
520    9_
$a Mast cells play a key role in allergy and other inflammatory diseases involving engagement of multivalent antigen with IgE bound to high-affinity IgE receptors (FcεRIs). Aggregation of FcεRIs on mast cells initiates a cascade of signaling events that eventually lead to degranulation, secretion of leukotrienes and prostaglandins, and cytokine and chemokine production contributing to the inflammatory response. Exposure to pro-inflammatory cytokines, chemokines, bacterial and viral products, as well as some other biological products and drugs, induces mast cell transition from the basal state into a primed one, which leads to enhanced response to IgE-antigen complexes. Mast cell priming changes the threshold for antigen-mediated activation by various mechanisms, depending on the priming agent used, which alone usually do not induce mast cell degranulation. In this review, we describe the priming processes induced in mast cells by various cytokines (stem cell factor, interleukins-4, -6 and -33), chemokines, other agents acting through G protein-coupled receptors (adenosine, prostaglandin E2 , sphingosine-1-phosphate, and β-2-adrenergic receptor agonists), toll-like receptors, and various drugs affecting the cytoskeleton. We will review the current knowledge about the molecular mechanisms behind priming of mast cells leading to degranulation and cytokine production and discuss the biological effects of mast cell priming induced by several cytokines.
650    12
$a degranulace buněk $7 D015550
650    _2
$a chemokiny $x metabolismus $7 D018925
650    _2
$a cytokiny $x metabolismus $7 D016207
650    _2
$a alergie $x imunologie $7 D006967
650    _2
$a imunizace $7 D007114
650    _2
$a imunoglobulin E $x metabolismus $7 D007073
650    _2
$a mediátory zánětu $x metabolismus $7 D018836
650    _2
$a mastocyty $x imunologie $7 D008407
650    _2
$a receptory spřažené s G-proteiny $x metabolismus $7 D043562
650    _2
$a receptory IgE $x metabolismus $7 D017455
650    _2
$a signální transdukce $7 D015398
650    _2
$a toll-like receptory $x metabolismus $7 D051193
655    _2
$a časopisecké články $7 D016428
655    _2
$a práce podpořená grantem $7 D013485
655    _2
$a přehledy $7 D016454
700    1_
$a Rönnberg, Elin $u Immunology and Allergy Unit, Department of Medicine, Karolinska Institutet and Clinical Immunology and Transfusion Medicine, Karolinska University Hospital, Stockholm, Sweden.
700    1_
$a Draberova, Lubica $u Department of Signal Transduction, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic.
700    1_
$a Vliagoftis, Harissios $u Immunology and Allergy Unit, Department of Medicine, Karolinska Institutet and Clinical Immunology and Transfusion Medicine, Karolinska University Hospital, Stockholm, Sweden. Alberta Respiratory Center and Department of Medicine, University of Alberta, Edmonton, AB, Canada.
700    1_
$a Nilsson, Gunnar P $u Immunology and Allergy Unit, Department of Medicine, Karolinska Institutet and Clinical Immunology and Transfusion Medicine, Karolinska University Hospital, Stockholm, Sweden. Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
700    1_
$a Draber, Petr $u Department of Signal Transduction, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic.
773    0_
$w MED00002193 $t Immunological reviews $x 1600-065X $g Roč. 282, č. 1 (2018), s. 73-86
856    41
$u https://pubmed.ncbi.nlm.nih.gov/29431203 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20190405 $b ABA008
991    __
$a 20190412092440 $b ABA008
999    __
$a ok $b bmc $g 1392154 $s 1051149
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2018 $b 282 $c 1 $d 73-86 $i 1600-065X $m Immunological reviews $n Immunol Rev $x MED00002193
LZP    __
$a Pubmed-20190405

Najít záznam

Citační ukazatele

Možnosti archivace