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High hydrostatic pressure in cancer immunotherapy and biomedicine

I. Adkins, N. Hradilova, O. Palata, L. Sadilkova, L. Palova-Jelinkova, R. Spisek,

. 2018 ; 36 (3) : 577-582. [pub] 20180201

Jazyk angličtina Země Anglie, Velká Británie

Typ dokumentu časopisecké články, práce podpořená grantem, přehledy

Perzistentní odkaz   https://www.medvik.cz/link/bmc19012859

High hydrostatic pressure (HHP) has been known to affect biological systems for >100 years. In this review, we describe the technology of HHP and its effect macromolecules and physiology of eukaryotic cells. We discuss the use of HHP in cancer immunotherapy to kill tumor cells for generation of whole cell and dendritic cell-based vaccines. We further summarize the current use and perspectives of HHP application in biomedicine, specifically in orthopedic surgery and for the viral, microbial and protozoan inactivation to develop vaccines against infectious diseases.

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$a High hydrostatic pressure (HHP) has been known to affect biological systems for >100 years. In this review, we describe the technology of HHP and its effect macromolecules and physiology of eukaryotic cells. We discuss the use of HHP in cancer immunotherapy to kill tumor cells for generation of whole cell and dendritic cell-based vaccines. We further summarize the current use and perspectives of HHP application in biomedicine, specifically in orthopedic surgery and for the viral, microbial and protozoan inactivation to develop vaccines against infectious diseases.
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$a Hradilova, Nada $u Sotio a.s, Prague, Czech Republic; Department of Immunology, 2nd Faculty of Medicine, Charles University, University Hospital Motol, Prague, Czech Republic.
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$a Palata, Ondrej $u Sotio a.s, Prague, Czech Republic; Department of Immunology, 2nd Faculty of Medicine, Charles University, University Hospital Motol, Prague, Czech Republic.
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$a Sadilkova, Lenka $u Sotio a.s, Prague, Czech Republic.
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$a Palova-Jelinkova, Lenka $u Department of Immunology, 2nd Faculty of Medicine, Charles University, University Hospital Motol, Prague, Czech Republic.
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$a Spisek, Radek $u Sotio a.s, Prague, Czech Republic; Department of Immunology, 2nd Faculty of Medicine, Charles University, University Hospital Motol, Prague, Czech Republic.
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