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Widespread white matter microstructural differences in schizophrenia across 4322 individuals: results from the ENIGMA Schizophrenia DTI Working Group
S. Kelly, N. Jahanshad, A. Zalesky, P. Kochunov, I. Agartz, C. Alloza, OA. Andreassen, C. Arango, N. Banaj, S. Bouix, CA. Bousman, RM. Brouwer, J. Bruggemann, J. Bustillo, W. Cahn, V. Calhoun, D. Cannon, V. Carr, S. Catts, J. Chen, JX. Chen, X....
Molecular psychiatry.
2018 ;
23 (5) :
1261-1269.
[pub] 20171017
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články, Research Support, N.I.H., Extramural, práce podpořená grantem, Research Support, U.S. Gov't, Non-P.H.S.
Perzistentní odkaz
https://www.medvik.cz/link/bmc19013053
PubMed
29038599
DOI
10.1038/mp.2017.170
Knihovny.cz E-zdroje
- MeSH
- bílá hmota patofyziologie ultrastruktura MeSH
- corpus callosum patofyziologie MeSH
- difuzní magnetická rezonance metody MeSH
- dospělí MeSH
- kohortové studie MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladý dospělý MeSH
- mozek patofyziologie MeSH
- počítačové zpracování obrazu MeSH
- schizofrenie diagnostické zobrazování patofyziologie MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- zobrazování difuzních tenzorů metody MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Research Support, N.I.H., Extramural MeSH
- Research Support, U.S. Gov't, Non-P.H.S. MeSH
The regional distribution of white matter (WM) abnormalities in schizophrenia remains poorly understood, and reported disease effects on the brain vary widely between studies. In an effort to identify commonalities across studies, we perform what we believe is the first ever large-scale coordinated study of WM microstructural differences in schizophrenia. Our analysis consisted of 2359 healthy controls and 1963 schizophrenia patients from 29 independent international studies; we harmonized the processing and statistical analyses of diffusion tensor imaging (DTI) data across sites and meta-analyzed effects across studies. Significant reductions in fractional anisotropy (FA) in schizophrenia patients were widespread, and detected in 20 of 25 regions of interest within a WM skeleton representing all major WM fasciculi. Effect sizes varied by region, peaking at (d=0.42) for the entire WM skeleton, driven more by peripheral areas as opposed to the core WM where regions of interest were defined. The anterior corona radiata (d=0.40) and corpus callosum (d=0.39), specifically its body (d=0.39) and genu (d=0.37), showed greatest effects. Significant decreases, to lesser degrees, were observed in almost all regions analyzed. Larger effect sizes were observed for FA than diffusivity measures; significantly higher mean and radial diffusivity was observed for schizophrenia patients compared with controls. No significant effects of age at onset of schizophrenia or medication dosage were detected. As the largest coordinated analysis of WM differences in a psychiatric disorder to date, the present study provides a robust profile of widespread WM abnormalities in schizophrenia patients worldwide. Interactive three-dimensional visualization of the results is available at www.enigma-viewer.org.
Beijing Huilongguan Hospital Beijing China
Brain and Mind Centre University of Sydney Sydney NSW Australia
Center for Addiction and Mental Health Toronto ON Canada
Chongqing Three Gorges Central Hospital Chongqing China
Department of Computer Science and Electrical Engineering University of Maryland Baltimore MD USA
Department of Computer Science and Engineering The Ohio State University Columbus OH USA
Department of Psychiatry and Human Behavior University of California Irvine Irvine CA USA
Department of Psychiatry and Mental Health University of Cape Town Cape Town South Africa
Department of Psychiatry Brigham and Women's Hospital Harvard Medical School Boston MA USA
Department of Psychiatry Osaka University Graduate School of Medicine Osaka Japan
Department of Psychiatry Seoul National University College of Medicine Seoul Republic of Korea
Department of Psychiatry Trinity College Dublin Dublin Ireland
Department of Psychiatry University of Iowa Iowa City IA USA
Department of Psychiatry University of Minnesota Minneapolis MN USA
Department of Psychiatry University of Pennsylvania Philadelphia PA USA
Department of Psychiatry Yale University School of Medicine New Haven CT USA
Discipline of Psychiatry School of Medicine University of Queensland Herston QLD Australia
Division of Cerebral Integration National Institute for Physiological Sciences Aichi Japan
Erasmus University Medical Center Rotterdam The Netherlands
Instituto de Alta Tecnología Médica Medellín Colombia
Luoyang 5th People's Hospital Henan Province China
Murdoch Childrens Research Institute The Royal Children's Hospital Parkville VIC Australia
Neuropsychiatry Unit Royal Melbourne Hospital Parkville VIC Australia
Psychology Department and Neuroscience Institute Georgia State University Atlanta GA USA
Santa Lucia Foundation Rome Italy
University of California VAMC San Francisco CA USA
University of Edinburgh Edinburgh UK
University of Iowa Iowa City IA USA
University of New Mexico Albuquerque NM USA
University of New South Wales School of Psychiatry Sydney NSW Australia
University of Oslo Oslo Norway
University of Western Australia Perth WA Australia
VABHS Harvard Medical School Boston MA USA
Citace poskytuje Crossref.org
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- $a Widespread white matter microstructural differences in schizophrenia across 4322 individuals: results from the ENIGMA Schizophrenia DTI Working Group / $c S. Kelly, N. Jahanshad, A. Zalesky, P. Kochunov, I. Agartz, C. Alloza, OA. Andreassen, C. Arango, N. Banaj, S. Bouix, CA. Bousman, RM. Brouwer, J. Bruggemann, J. Bustillo, W. Cahn, V. Calhoun, D. Cannon, V. Carr, S. Catts, J. Chen, JX. Chen, X. Chen, C. Chiapponi, KK. Cho, V. Ciullo, AS. Corvin, B. Crespo-Facorro, V. Cropley, P. De Rossi, CM. Diaz-Caneja, EW. Dickie, S. Ehrlich, FM. Fan, J. Faskowitz, H. Fatouros-Bergman, L. Flyckt, JM. Ford, JP. Fouche, M. Fukunaga, M. Gill, DC. Glahn, R. Gollub, ED. Goudzwaard, H. Guo, RE. Gur, RC. Gur, TP. Gurholt, R. Hashimoto, SN. Hatton, FA. Henskens, DP. Hibar, IB. Hickie, LE. Hong, J. Horacek, FM. Howells, HE. Hulshoff Pol, CL. Hyde, D. Isaev, A. Jablensky, PR. Jansen, J. Janssen, EG. Jönsson, LA. Jung, RS. Kahn, Z. Kikinis, K. Liu, P. Klauser, C. Knöchel, M. Kubicki, J. Lagopoulos, C. Langen, S. Lawrie, RK. Lenroot, KO. Lim, C. Lopez-Jaramillo, A. Lyall, V. Magnotta, RCW. Mandl, DH. Mathalon, RW. McCarley, S. McCarthy-Jones, C. McDonald, S. McEwen, A. McIntosh, T. Melicher, RI. Mesholam-Gately, PT. Michie, B. Mowry, BA. Mueller, DT. Newell, P. O'Donnell, V. Oertel-Knöchel, L. Oestreich, SA. Paciga, C. Pantelis, O. Pasternak, G. Pearlson, GR. Pellicano, A. Pereira, J. Pineda Zapata, F. Piras, SG. Potkin, A. Preda, PE. Rasser, DR. Roalf, R. Roiz, A. Roos, D. Rotenberg, TD. Satterthwaite, P. Savadjiev, U. Schall, RJ. Scott, ML. Seal, LJ. Seidman, C. Shannon Weickert, CD. Whelan, ME. Shenton, JS. Kwon, G. Spalletta, F. Spaniel, E. Sprooten, M. Stäblein, DJ. Stein, S. Sundram, Y. Tan, S. Tan, S. Tang, HS. Temmingh, LT. Westlye, S. Tønnesen, D. Tordesillas-Gutierrez, NT. Doan, J. Vaidya, NEM. van Haren, CD. Vargas, D. Vecchio, D. Velakoulis, A. Voineskos, JQ. Voyvodic, Z. Wang, P. Wan, D. Wei, TW. Weickert, H. Whalley, T. White, TJ. Whitford, JD. Wojcik, H. Xiang, Z. Xie, H. Yamamori, F. Yang, N. Yao, G. Zhang, J. Zhao, TGM. van Erp, J. Turner, PM. Thompson, G. Donohoe,
- 520 9_
- $a The regional distribution of white matter (WM) abnormalities in schizophrenia remains poorly understood, and reported disease effects on the brain vary widely between studies. In an effort to identify commonalities across studies, we perform what we believe is the first ever large-scale coordinated study of WM microstructural differences in schizophrenia. Our analysis consisted of 2359 healthy controls and 1963 schizophrenia patients from 29 independent international studies; we harmonized the processing and statistical analyses of diffusion tensor imaging (DTI) data across sites and meta-analyzed effects across studies. Significant reductions in fractional anisotropy (FA) in schizophrenia patients were widespread, and detected in 20 of 25 regions of interest within a WM skeleton representing all major WM fasciculi. Effect sizes varied by region, peaking at (d=0.42) for the entire WM skeleton, driven more by peripheral areas as opposed to the core WM where regions of interest were defined. The anterior corona radiata (d=0.40) and corpus callosum (d=0.39), specifically its body (d=0.39) and genu (d=0.37), showed greatest effects. Significant decreases, to lesser degrees, were observed in almost all regions analyzed. Larger effect sizes were observed for FA than diffusivity measures; significantly higher mean and radial diffusivity was observed for schizophrenia patients compared with controls. No significant effects of age at onset of schizophrenia or medication dosage were detected. As the largest coordinated analysis of WM differences in a psychiatric disorder to date, the present study provides a robust profile of widespread WM abnormalities in schizophrenia patients worldwide. Interactive three-dimensional visualization of the results is available at www.enigma-viewer.org.
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- 700 1_
- $a Pellicano, G R $u Laboratory of Neuropsychiatry, Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Rome, Italy.
- 700 1_
- $a Pereira, A $u The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, VIC, Australia.
- 700 1_
- $a Pineda Zapata, J $u Instituto de Alta Tecnología Médica, Medellín, Colombia.
- 700 1_
- $a Piras, F $u Laboratory of Neuropsychiatry, Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Rome, Italy. School of Biomedical Sciences, Faculty of Health, the University of Newcastle, Callaghan, NSW, Australia.
- 700 1_
- $a Potkin, S G $u Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, CA, USA.
- 700 1_
- $a Preda, A $u Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, CA, USA.
- 700 1_
- $a Rasser, P E $u Hunter Medical Research Institute, Newcastle, NSW, Australia. Priority Centre for Brain and Mental Health Research, The University of Newcastle, Newcastle, NSW, Australia.
- 700 1_
- $a Roalf, D R $u Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA.
- 700 1_
- $a Roiz, R $u University Hospital Marqués de Valdecilla, IDIVAL, Department of Medicine and Psychiatry, School of Medicine, University of Cantabria, Santander, Spain. CIBERSAM, Centro Investigación Biomédica en Red Salud Mental, Santander, Spain.
- 700 1_
- $a Roos, A $u SU/UCT MRC Unit on Anxiety and Stress Disorders, Department of Psychiatry, Stellenbosch University, Stellenbosch, South Africa.
- 700 1_
- $a Rotenberg, D $u Center for Addiction and Mental Health, Toronto, ON, Canada.
- 700 1_
- $a Satterthwaite, T D $u Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA.
- 700 1_
- $a Savadjiev, P $u Departments of Psychiatry and Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
- 700 1_
- $a Schall, U $u Hunter Medical Research Institute, Newcastle, NSW, Australia. Priority Centre for Brain and Mental Health Research, The University of Newcastle, Newcastle, NSW, Australia.
- 700 1_
- $a Scott, R J $u Hunter Medical Research Institute, Newcastle, NSW, Australia. School of Biomedical Sciences, Faculty of Health, the University of Newcastle, Callaghan, NSW, Australia.
- 700 1_
- $a Seal, M L $u Murdoch Childrens Research Institute, The Royal Children's Hospital, Parkville, VIC, Australia.
- 700 1_
- $a Seidman, L J $u Harvard Medical School, Boston, MA, USA. Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. Harvard Medical School and Massachusetts Mental Health Center Public Psychiatry Division of the Beth Israel Deaconess, Medical Center, Boston, MA, USA.
- 700 1_
- $a Shannon Weickert, C $u Schizophrenia Research Institute, Sydney, NSW, Australia. Neuroscience Research Australia, Sydney, NSW, Australia. School of Psychiatry, University of New South Wales, Sydney, NSW, Australia.
- 700 1_
- $a Whelan, C D $u Imaging Genetics Center, Stevens Neuroimaging & Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.
- 700 1_
- $a Shenton, M E $u Departments of Psychiatry and Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. VA Boston Healthcare System, Boston, MA, USA.
- 700 1_
- $a Kwon, J S $u Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea.
- 700 1_
- $a Spalletta, G $u Laboratory of Neuropsychiatry, Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Rome, Italy. Division of Neuropsychiatry, Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA.
- 700 1_
- $a Spaniel, F $u National Institute of Mental Health, Klecany, Czech Republic. Third Faculty of Medicine, Charles University, Prague, Czech Republic.
- 700 1_
- $a Sprooten, E $u Olin Neuropsychiatric Research Center, Institute of Living, Hartford Hospital and Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
- 700 1_
- $a Stäblein, M $u Laboratory for Neuroimaging, Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe University, Frankfurt/Main, Germany.
- 700 1_
- $a Stein, D J $u Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa. Department of Psychiatry and MRC Unit on Anxiety and Stress Disorders, University of Cape Town, Cape Town, South Africa.
- 700 1_
- $a Sundram, S $u Florey Institute of Neuroscience and Mental Health, Parkville, VIC, Australia. Department of Psychiatry, School of Clinical Sciences, Monash University and Monash Health, Clayton, VIC, Australia.
- 700 1_
- $a Tan, Y $u Beijing Huilongguan Hospital, Beijing, China.
- 700 1_
- $a Tan, S $u Beijing Huilongguan Hospital, Beijing, China.
- 700 1_
- $a Tang, S $u Chongqing Three Gorges Central Hospital, Chongqing, China.
- 700 1_
- $a Temmingh, H S $u Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa.
- 700 1_
- $a Westlye, L T $u NORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, Norway. Department of Psychology, University of Oslo, Oslo, Norway.
- 700 1_
- $a Tønnesen, S $u NORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
- 700 1_
- $a Tordesillas-Gutierrez, D $u CIBERSAM, Centro Investigación Biomédica en Red Salud Mental, Santander, Spain. Neuroimaging Unit, Technological Facilities, Valdecilla Biomedical Research Institute IDIVAL, Santander, Spain.
- 700 1_
- $a Doan, N T $u NORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
- 700 1_
- $a Vaidya, J $u Department of Psychiatry, University of Iowa, Iowa City, IA, USA.
- 700 1_
- $a van Haren, N E M $u Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.
- 700 1_
- $a Vargas, C D $u Research Group in Psychiatry (GIPSI), Department of Psychiatry, Faculty of Medicine, Universidad de Antioquia, Medellín, Colombia.
- 700 1_
- $a Vecchio, D $u Laboratory of Neuropsychiatry, Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Rome, Italy.
- 700 1_
- $a Velakoulis, D $u Neuropsychiatry Unit, Royal Melbourne Hospital, Parkville, VIC, Australia.
- 700 1_
- $a Voineskos, A $u Kimel Family Translational Imaging-Genetics Research Laboratory, Campbell Family Mental Health Research Institute, CAMH Department of Psychiatry, University of Toronto, Toronto, ON, Canada.
- 700 1_
- $a Voyvodic, J Q $u Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.
- 700 1_
- $a Wang, Z $u Beijing Huilongguan Hospital, Beijing, China.
- 700 1_
- $a Wan, P $u Zhumadian Psychiatry Hospital, Henan Province, China.
- 700 1_
- $a Wei, D $u Luoyang Fifth People's Hospital, Henan Province, China.
- 700 1_
- $a Weickert, T W $u Schizophrenia Research Institute, Sydney, NSW, Australia. Neuroscience Research Australia, Sydney, NSW, Australia. School of Psychiatry, University of New South Wales, Sydney, NSW, Australia.
- 700 1_
- $a Whalley, H $u University of Edinburgh, Edinburgh, UK.
- 700 1_
- $a White, T $u Erasmus University Medical Center, Rotterdam, The Netherlands.
- 700 1_
- $a Whitford, T J $u University of New South Wales, School of Psychiatry, Sydney, NSW, Australia.
- 700 1_
- $a Wojcik, J D $u Harvard Medical School and Massachusetts Mental Health Center Public Psychiatry Division of the Beth Israel Deaconess, Medical Center, Boston, MA, USA.
- 700 1_
- $a Xiang, H $u Chongqing Three Gorges Central Hospital, Chongqing, China.
- 700 1_
- $a Xie, Z $u Worldwide Research and Development, Pfizer, Cambridge, MA, USA.
- 700 1_
- $a Yamamori, H $u Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan.
- 700 1_
- $a Yang, F $u Beijing Huilongguan Hospital, Beijing, China.
- 700 1_
- $a Yao, N $u Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
- 700 1_
- $a Zhang, G $u Department of Computer Science and Electrical Engineering, University of Maryland, Baltimore, MD, USA.
- 700 1_
- $a Zhao, J $u Centre for Neuroimaging and Cognitive Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, National University of Ireland Galway, Galway, Ireland. School of Psychology, Shaanxi Normal University and Key Laboratory for Behavior and Cognitive Neuroscience of Shaanxi Province, Xi'an, Shaanxi, China.
- 700 1_
- $a van Erp, T G M $u Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, CA, USA.
- 700 1_
- $a Turner, J $u Psychology Department & Neuroscience Institute, Georgia State University, Atlanta, GA, USA.
- 700 1_
- $a Thompson, P M $u Imaging Genetics Center, Stevens Neuroimaging & Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.
- 700 1_
- $a Donohoe, G $u Centre for Neuroimaging and Cognitive Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, National University of Ireland Galway, Galway, Ireland.
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