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Diagnosis and severity criteria for sinusoidal obstruction syndrome/veno-occlusive disease in pediatric patients: a new classification from the European society for blood and marrow transplantation
S. Corbacioglu, E. Carreras, M. Ansari, A. Balduzzi, S. Cesaro, JH. Dalle, F. Dignan, B. Gibson, T. Guengoer, B. Gruhn, A. Lankester, F. Locatelli, A. Pagliuca, C. Peters, PG. Richardson, AS. Schulz, P. Sedlacek, J. Stein, KW. Sykora, J....
Language English Country England, Great Britain
Document type Journal Article, Research Support, Non-U.S. Gov't
NLK
Free Medical Journals
from 1997 to 1 year ago
Freely Accessible Science Journals
from 1997 to 1 year ago
ProQuest Central
from 2000-01-01 to 1 year ago
Open Access Digital Library
from 1997-01-01
Health & Medicine (ProQuest)
from 2000-01-01 to 1 year ago
PubMed
28759025
DOI
10.1038/bmt.2017.161
Knihovny.cz E-resources
- MeSH
- Incidence MeSH
- Hepatic Veno-Occlusive Disease classification diagnosis pathology MeSH
- Humans MeSH
- Risk Factors MeSH
- Treatment Outcome MeSH
- Check Tag
- Humans MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Geographicals
- Europe MeSH
The advances in hematopoietic cell transplantation (HCT) over the last decade have led to a transplant-related mortality below 15%. Hepatic sinusoidal obstruction syndrome/veno-occlusive disease (SOS/VOD) is a life-threatening complication of HCT that belongs to a group of diseases increasingly identified as transplant-related, systemic endothelial diseases. In most cases, SOS/VOD resolves within weeks; however, severe SOS/VOD results in multi-organ dysfunction/failure with a mortality rate >80%. A timely diagnosis of SOS/VOD is of critical importance, given the availability of therapeutic options with favorable tolerability. Current diagnostic criteria are used for adults and children. However, over the last decade it has become clear that SOS/VOD is significantly different between the age groups in terms of incidence, genetic predisposition, clinical presentation, prevention, treatment and outcome. Improved understanding of SOS/VOD and the availability of effective treatment questions the use of the Baltimore and Seattle criteria for diagnosing SOS/VOD in children. The aim of this position paper is to propose new diagnostic and severity criteria for SOS/VOD in children on behalf of the European Society for Blood and Marrow Transplantation.
Children's Hospital University of Helsinki Helsinki Finland
Department of Clinical Haematology Manchester Royal Infirmary Manchester UK
Department of Haematology King's College Hospital London UK
Department of Pediatric Oncohematology Giambattista Rossi University Hospital Verona Italy
Department of Pediatrics Leiden University Medical Center Leiden The Netherlands
Department of Pediatrics St Anna Kinderspital Vienna Austria
Department of Pediatrics University Children's Hospital Ulm Germany
Department of Pediatrics University Hospital Motol Prague Czech Republic
Department of Pediatrics University Hospital of Jena Jena Germany
Division of Blood and Marrow Transplantation University Children's Hospital Zurich Switzerland
Hemato Oncology Unit Department of Pediatrics University Hospital of Geneva Geneva Switzerland
Hôpital Saint Antoine APHP Université Pierre and Marie Curie INSERM UMRS 938 Paris France
Pediatric Clinic University of Milano Bicocca San Gerardo Hospital Milan Italy
Pediatric Hematology Oncology Children's Hospital Medical School Hannover Germany
Pediatric Stem Cell Transplantation Unit Bahçeşehir University School of Medicine Istanbul Turkey
Royal Hospital for Sick Children Glasgow UK
Royal Manchester Children's Hospital Manchester UK
Section of Hematology and Coagulation Sahlgrenska University Hospital Gothenburg Sweden
References provided by Crossref.org
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