Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

Ticks infected via co-feeding transmission can transmit Lyme borreliosis to vertebrate hosts

A. Belli, A. Sarr, O. Rais, ROM. Rego, MJ. Voordouw,

. 2017 ; 7 (1) : 5006. [pub] 20170710

Jazyk angličtina Země Anglie, Velká Británie

Typ dokumentu srovnávací studie, časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc19013130

Vector-borne pathogens establish systemic infections in host tissues to maximize transmission to arthropod vectors. Co-feeding transmission occurs when the pathogen is transferred between infected and naive vectors that feed in close spatiotemporal proximity on a host that has not yet developed a systemic infection. Borrelia afzelii is a tick-borne spirochete bacterium that causes Lyme borreliosis (LB) and is capable of co-feeding transmission. Whether ticks that acquire LB pathogens via co-feeding are actually infectious to vertebrate hosts has never been tested. We created nymphs that had been experimentally infected as larvae with B. afzelii via co-feeding or systemic transmission, and compared their performance over one complete LB life cycle. Co-feeding nymphs had a spirochete load that was 26 times lower than systemic nymphs but both nymphs were highly infectious to mice (i.e., probability of nymph-to-host transmission of B. afzelii was ~100%). The mode of transmission had no effect on the other infection phenotypes of the LB life cycle. Ticks that acquire B. afzelii via co-feeding transmission are highly infectious to rodents, and the resulting rodent infection is highly infectious to larval ticks. This is the first study to show that B. afzelii can use co-feeding transmission to complete its life cycle.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc19013130
003      
CZ-PrNML
005      
20190405092911.0
007      
ta
008      
190405s2017 enk f 000 0|eng||
009      
AR
024    7_
$a 10.1038/s41598-017-05231-1 $2 doi
035    __
$a (PubMed)28694446
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a enk
100    1_
$a Belli, Alessandro $u Laboratory of Ecology and Evolution of Parasites, Institute of Biology, University of Neuchâtel, Neuchâtel, Switzerland.
245    10
$a Ticks infected via co-feeding transmission can transmit Lyme borreliosis to vertebrate hosts / $c A. Belli, A. Sarr, O. Rais, ROM. Rego, MJ. Voordouw,
520    9_
$a Vector-borne pathogens establish systemic infections in host tissues to maximize transmission to arthropod vectors. Co-feeding transmission occurs when the pathogen is transferred between infected and naive vectors that feed in close spatiotemporal proximity on a host that has not yet developed a systemic infection. Borrelia afzelii is a tick-borne spirochete bacterium that causes Lyme borreliosis (LB) and is capable of co-feeding transmission. Whether ticks that acquire LB pathogens via co-feeding are actually infectious to vertebrate hosts has never been tested. We created nymphs that had been experimentally infected as larvae with B. afzelii via co-feeding or systemic transmission, and compared their performance over one complete LB life cycle. Co-feeding nymphs had a spirochete load that was 26 times lower than systemic nymphs but both nymphs were highly infectious to mice (i.e., probability of nymph-to-host transmission of B. afzelii was ~100%). The mode of transmission had no effect on the other infection phenotypes of the LB life cycle. Ticks that acquire B. afzelii via co-feeding transmission are highly infectious to rodents, and the resulting rodent infection is highly infectious to larval ticks. This is the first study to show that B. afzelii can use co-feeding transmission to complete its life cycle.
650    _2
$a krmivo pro zvířata $x mikrobiologie $7 D000821
650    _2
$a zvířata $7 D000818
650    _2
$a arachnida jako vektory $x mikrobiologie $x fyziologie $7 D001096
650    _2
$a zdroje nemoci $x mikrobiologie $7 D004197
650    _2
$a stadia vývoje $7 D008018
650    _2
$a lymeská nemoc $x mikrobiologie $x přenos $7 D008193
650    _2
$a myši $7 D051379
650    _2
$a nymfa $x mikrobiologie $x fyziologie $7 D009758
650    _2
$a klíšťata $x mikrobiologie $x fyziologie $7 D013987
655    _2
$a srovnávací studie $7 D003160
655    _2
$a časopisecké články $7 D016428
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Sarr, Anouk $u Laboratory of Ecology and Evolution of Parasites, Institute of Biology, University of Neuchâtel, Neuchâtel, Switzerland.
700    1_
$a Rais, Olivier $u Laboratory of Ecology and Epidemiology of Parasites, Institute of Biology, University of Neuchâtel, Neuchâtel, Switzerland.
700    1_
$a Rego, Ryan O M $u Institute of Parasitology, ASCR, Biology Centre, Ceske Budejovice, Czech Republic.
700    1_
$a Voordouw, Maarten J $u Laboratory of Ecology and Evolution of Parasites, Institute of Biology, University of Neuchâtel, Neuchâtel, Switzerland. maarten.voordouw@unine.ch.
773    0_
$w MED00182195 $t Scientific reports $x 2045-2322 $g Roč. 7, č. 1 (2017), s. 5006
856    41
$u https://pubmed.ncbi.nlm.nih.gov/28694446 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20190405 $b ABA008
991    __
$a 20190405092920 $b ABA008
999    __
$a ok $b bmc $g 1392440 $s 1051435
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2017 $b 7 $c 1 $d 5006 $e 20170710 $i 2045-2322 $m Scientific reports $n Sci Rep $x MED00182195
LZP    __
$a Pubmed-20190405

Najít záznam

Citační ukazatele

Pouze přihlášení uživatelé

Možnosti archivace