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Cognitive Control Processes and Functional Cerebral Asymmetries: Association with Variation in the Handedness-Associated Gene LRRTM1
C. Beste, L. Arning, WM. Gerding, JT. Epplen, A. Mertins, MC. Röder, JJ. Bless, K. Hugdahl, R. Westerhausen, O. Güntürkün, S. Ocklenburg,
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, práce podpořená grantem
NLK
ProQuest Central
od 1997-02-01 do Před 1 rokem
Medline Complete (EBSCOhost)
od 2010-02-01 do Před 1 rokem
Health & Medicine (ProQuest)
od 1997-02-01 do Před 1 rokem
Psychology Database (ProQuest)
od 1997-02-01 do Před 1 rokem
- MeSH
- akustická stimulace metody MeSH
- dospělí MeSH
- funkční lateralita fyziologie MeSH
- jazyk (prostředek komunikace) MeSH
- kognice fyziologie MeSH
- lidé MeSH
- membránové proteiny genetika MeSH
- mladiství MeSH
- mladý dospělý MeSH
- mozková kůra fyziologie MeSH
- pozornost fyziologie MeSH
- proteiny nervové tkáně genetika MeSH
- průzkumy a dotazníky MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
Cognitive control processes play an essential role not only in controlling actions but also in guiding attentional selection processes. Interestingly, these processes are strongly affected by organizational principles of the cerebral cortex and related functional asymmetries, but the neurobiological foundations are elusive. We ask whether neurobiological mechanisms that affect functional cerebral asymmetries will also modulate effects of top-down control processes on functional cerebral asymmetries. To this end, we examined potential effects of the imprinted gene leucine-rich repeat transmembrane neuronal 1 (LRRTM1) on attentional biasing processes in a forced attention dichotic listening task in 983 healthy adult participants of Caucasian descent using the "iDichotic smartphone app." The results show that functional cerebral asymmetries in the language domain are associated with the rs6733871 LRRTM1 polymorphism when cognitive control and top-down attentional mechanisms modulate processes in bottom-up attentional selection processes that are dependent on functional cerebral asymmetries. There is no evidence for an effect of LRRTM1 on functional cerebral asymmetries in the language domain unrelated to cognitive control processes. The results suggest that cognitive control processes are an important factor to consider when being interested in the molecular genetic basis of functional cerebral architecture.
Department of Biological and Medical Psychology University of Bergen Bergen Norway
Department of Human Genetics Ruhr University Bochum Bochum Germany
Citace poskytuje Crossref.org
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- $a Beste, Christian $u Cognitive Neurophysiology, Department of Child and Adolescent Psychiatry, Faculty of Medicine, TU Dresden, Schubertstrasse 42, 01309, Dresden, Germany. christian.beste@uniklinikum-dresden.de. Experimental Neurobiology, National Institute of Mental Health, Klecany, Czech Republic. christian.beste@uniklinikum-dresden.de.
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- $a Cognitive control processes play an essential role not only in controlling actions but also in guiding attentional selection processes. Interestingly, these processes are strongly affected by organizational principles of the cerebral cortex and related functional asymmetries, but the neurobiological foundations are elusive. We ask whether neurobiological mechanisms that affect functional cerebral asymmetries will also modulate effects of top-down control processes on functional cerebral asymmetries. To this end, we examined potential effects of the imprinted gene leucine-rich repeat transmembrane neuronal 1 (LRRTM1) on attentional biasing processes in a forced attention dichotic listening task in 983 healthy adult participants of Caucasian descent using the "iDichotic smartphone app." The results show that functional cerebral asymmetries in the language domain are associated with the rs6733871 LRRTM1 polymorphism when cognitive control and top-down attentional mechanisms modulate processes in bottom-up attentional selection processes that are dependent on functional cerebral asymmetries. There is no evidence for an effect of LRRTM1 on functional cerebral asymmetries in the language domain unrelated to cognitive control processes. The results suggest that cognitive control processes are an important factor to consider when being interested in the molecular genetic basis of functional cerebral architecture.
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- $a Arning, Larissa $u Department of Human Genetics, Ruhr-University Bochum, Bochum, Germany.
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- $a Hugdahl, Kenneth $u Department of Biological and Medical Psychology, University of Bergen, Bergen, Norway. NORMENT Center of Excellence, University of Oslo, Oslo, Norway. Department of Psychiatry, Haukekland University Hospital, Bergen, Norway.
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- $a Westerhausen, René $u Department of Psychology, University of Oslo, Oslo, Norway.
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