Cognitive control processes play an essential role not only in controlling actions but also in guiding attentional selection processes. Interestingly, these processes are strongly affected by organizational principles of the cerebral cortex and related functional asymmetries, but the neurobiological foundations are elusive. We ask whether neurobiological mechanisms that affect functional cerebral asymmetries will also modulate effects of top-down control processes on functional cerebral asymmetries. To this end, we examined potential effects of the imprinted gene leucine-rich repeat transmembrane neuronal 1 (LRRTM1) on attentional biasing processes in a forced attention dichotic listening task in 983 healthy adult participants of Caucasian descent using the "iDichotic smartphone app." The results show that functional cerebral asymmetries in the language domain are associated with the rs6733871 LRRTM1 polymorphism when cognitive control and top-down attentional mechanisms modulate processes in bottom-up attentional selection processes that are dependent on functional cerebral asymmetries. There is no evidence for an effect of LRRTM1 on functional cerebral asymmetries in the language domain unrelated to cognitive control processes. The results suggest that cognitive control processes are an important factor to consider when being interested in the molecular genetic basis of functional cerebral architecture.

Cognitive Neurophysiology Department of Child and Adolescent Psychiatry Faculty of Medicine TU Dresden Schubertstrasse 42 01309 Dresden Germany

Department of Biological and Medical Psychology University of Bergen Bergen Norway

Department of Human Genetics Ruhr University Bochum Bochum Germany

Department of Psychiatry Haukekland University Hospital Bergen Norway

Department of Psychology University of Oslo Oslo Norway

Experimental Neurobiology National Institute of Mental Health Klecany Czech Republic

Institute of Cognitive Neuroscience Biopsychology Department of Psychology Ruhr University Bochum Bochum Germany

NORMENT Center of Excellence University of Oslo Oslo Norway

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