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Neurochemical responses to chromatic and achromatic stimuli in the human visual cortex
P. Bednařík, I. Tkáč, F. Giove, LE. Eberly, DK. Deelchand, FR. Barreto, S. Mangia,
Language English Country United States
Document type Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't
NLK
Free Medical Journals
from 2010
PubMed Central
from 2010 to 1 year ago
Europe PubMed Central
from 2010 to 1 year ago
Open Access Digital Library
from 1996-01-01
- MeSH
- Color * MeSH
- Energy Metabolism MeSH
- Glucose metabolism MeSH
- Aspartic Acid metabolism MeSH
- Glutamic Acid metabolism MeSH
- Lactic Acid metabolism MeSH
- Humans MeSH
- Magnetic Resonance Spectroscopy MeSH
- Magnetic Resonance Imaging MeSH
- Brain Chemistry physiology MeSH
- Neurons physiology MeSH
- Oxidation-Reduction MeSH
- Electron Transport Complex IV metabolism MeSH
- Photic Stimulation * MeSH
- Healthy Volunteers MeSH
- Evoked Potentials, Visual MeSH
- Visual Cortex metabolism physiology MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Research Support, N.I.H., Extramural MeSH
In the present study, we aimed at determining the metabolic responses of the human visual cortex during the presentation of chromatic and achromatic stimuli, known to preferentially activate two separate clusters of neuronal populations (called "blobs" and "interblobs") with distinct sensitivity to color or luminance features. Since blobs and interblobs have different cytochrome-oxidase (COX) content and micro-vascularization level (i.e., different capacities for glucose oxidation), different functional metabolic responses during chromatic vs. achromatic stimuli may be expected. The stimuli were optimized to evoke a similar load of neuronal activation as measured by the bold oxygenation level dependent (BOLD) contrast. Metabolic responses were assessed using functional 1H MRS at 7 T in 12 subjects. During both chromatic and achromatic stimuli, we observed the typical increases in glutamate and lactate concentration, and decreases in aspartate and glucose concentration, that are indicative of increased glucose oxidation. However, within the detection sensitivity limits, we did not observe any difference between metabolic responses elicited by chromatic and achromatic stimuli. We conclude that the higher energy demands of activated blobs and interblobs are supported by similar increases in oxidative metabolism despite the different capacities of these neuronal populations.
Division of Biostatistics School of Public Health University of Minnesota Minneapolis MN USA
Physics Department University of Sao Paulo Ribeirao Preto SP Brazil
References provided by Crossref.org
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- $a Bednařík, Petr, $d 1979- $7 mub2016934215 $u 1 Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN, USA. 2 Division of Endocrinology and Diabetes, Department of Medicine, University of Minnesota, Minneapolis, MN, USA. 3 CEITEC - Central European Institute of Technology, Masaryk University, Brno, Czech Republic.
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- $a In the present study, we aimed at determining the metabolic responses of the human visual cortex during the presentation of chromatic and achromatic stimuli, known to preferentially activate two separate clusters of neuronal populations (called "blobs" and "interblobs") with distinct sensitivity to color or luminance features. Since blobs and interblobs have different cytochrome-oxidase (COX) content and micro-vascularization level (i.e., different capacities for glucose oxidation), different functional metabolic responses during chromatic vs. achromatic stimuli may be expected. The stimuli were optimized to evoke a similar load of neuronal activation as measured by the bold oxygenation level dependent (BOLD) contrast. Metabolic responses were assessed using functional 1H MRS at 7 T in 12 subjects. During both chromatic and achromatic stimuli, we observed the typical increases in glutamate and lactate concentration, and decreases in aspartate and glucose concentration, that are indicative of increased glucose oxidation. However, within the detection sensitivity limits, we did not observe any difference between metabolic responses elicited by chromatic and achromatic stimuli. We conclude that the higher energy demands of activated blobs and interblobs are supported by similar increases in oxidative metabolism despite the different capacities of these neuronal populations.
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