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Neurochemical responses to chromatic and achromatic stimuli in the human visual cortex
P. Bednařík, I. Tkáč, F. Giove, LE. Eberly, DK. Deelchand, FR. Barreto, S. Mangia,
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, Research Support, N.I.H., Extramural, práce podpořená grantem
NLK
Free Medical Journals
od 2010
PubMed Central
od 2010 do Před 1 rokem
Europe PubMed Central
od 2010 do Před 1 rokem
Open Access Digital Library
od 1996-01-01
PubMed
28273721
DOI
10.1177/0271678x17695291
Knihovny.cz E-zdroje
- MeSH
- barva * MeSH
- energetický metabolismus MeSH
- glukosa metabolismus MeSH
- kyselina asparagová metabolismus MeSH
- kyselina glutamová metabolismus MeSH
- kyselina mléčná metabolismus MeSH
- lidé MeSH
- magnetická rezonanční spektroskopie MeSH
- magnetická rezonanční tomografie MeSH
- mozek - chemie fyziologie MeSH
- neurony fyziologie MeSH
- oxidace-redukce MeSH
- respirační komplex IV metabolismus MeSH
- světelná stimulace * MeSH
- zdraví dobrovolníci pro lékařské studie MeSH
- zrakové evokované potenciály MeSH
- zrakové korové centrum metabolismus fyziologie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Research Support, N.I.H., Extramural MeSH
In the present study, we aimed at determining the metabolic responses of the human visual cortex during the presentation of chromatic and achromatic stimuli, known to preferentially activate two separate clusters of neuronal populations (called "blobs" and "interblobs") with distinct sensitivity to color or luminance features. Since blobs and interblobs have different cytochrome-oxidase (COX) content and micro-vascularization level (i.e., different capacities for glucose oxidation), different functional metabolic responses during chromatic vs. achromatic stimuli may be expected. The stimuli were optimized to evoke a similar load of neuronal activation as measured by the bold oxygenation level dependent (BOLD) contrast. Metabolic responses were assessed using functional 1H MRS at 7 T in 12 subjects. During both chromatic and achromatic stimuli, we observed the typical increases in glutamate and lactate concentration, and decreases in aspartate and glucose concentration, that are indicative of increased glucose oxidation. However, within the detection sensitivity limits, we did not observe any difference between metabolic responses elicited by chromatic and achromatic stimuli. We conclude that the higher energy demands of activated blobs and interblobs are supported by similar increases in oxidative metabolism despite the different capacities of these neuronal populations.
Division of Biostatistics School of Public Health University of Minnesota Minneapolis MN USA
Physics Department University of Sao Paulo Ribeirao Preto SP Brazil
Citace poskytuje Crossref.org
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- $a Bednařík, Petr, $d 1979- $7 mub2016934215 $u 1 Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN, USA. 2 Division of Endocrinology and Diabetes, Department of Medicine, University of Minnesota, Minneapolis, MN, USA. 3 CEITEC - Central European Institute of Technology, Masaryk University, Brno, Czech Republic.
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- $a In the present study, we aimed at determining the metabolic responses of the human visual cortex during the presentation of chromatic and achromatic stimuli, known to preferentially activate two separate clusters of neuronal populations (called "blobs" and "interblobs") with distinct sensitivity to color or luminance features. Since blobs and interblobs have different cytochrome-oxidase (COX) content and micro-vascularization level (i.e., different capacities for glucose oxidation), different functional metabolic responses during chromatic vs. achromatic stimuli may be expected. The stimuli were optimized to evoke a similar load of neuronal activation as measured by the bold oxygenation level dependent (BOLD) contrast. Metabolic responses were assessed using functional 1H MRS at 7 T in 12 subjects. During both chromatic and achromatic stimuli, we observed the typical increases in glutamate and lactate concentration, and decreases in aspartate and glucose concentration, that are indicative of increased glucose oxidation. However, within the detection sensitivity limits, we did not observe any difference between metabolic responses elicited by chromatic and achromatic stimuli. We conclude that the higher energy demands of activated blobs and interblobs are supported by similar increases in oxidative metabolism despite the different capacities of these neuronal populations.
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