• Je něco špatně v tomto záznamu ?

Neurochemical responses to chromatic and achromatic stimuli in the human visual cortex

P. Bednařík, I. Tkáč, F. Giove, LE. Eberly, DK. Deelchand, FR. Barreto, S. Mangia,

. 2018 ; 38 (2) : 347-359. [pub] 20170224

Jazyk angličtina Země Spojené státy americké

Typ dokumentu časopisecké články, Research Support, N.I.H., Extramural, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc19013176

In the present study, we aimed at determining the metabolic responses of the human visual cortex during the presentation of chromatic and achromatic stimuli, known to preferentially activate two separate clusters of neuronal populations (called "blobs" and "interblobs") with distinct sensitivity to color or luminance features. Since blobs and interblobs have different cytochrome-oxidase (COX) content and micro-vascularization level (i.e., different capacities for glucose oxidation), different functional metabolic responses during chromatic vs. achromatic stimuli may be expected. The stimuli were optimized to evoke a similar load of neuronal activation as measured by the bold oxygenation level dependent (BOLD) contrast. Metabolic responses were assessed using functional 1H MRS at 7 T in 12 subjects. During both chromatic and achromatic stimuli, we observed the typical increases in glutamate and lactate concentration, and decreases in aspartate and glucose concentration, that are indicative of increased glucose oxidation. However, within the detection sensitivity limits, we did not observe any difference between metabolic responses elicited by chromatic and achromatic stimuli. We conclude that the higher energy demands of activated blobs and interblobs are supported by similar increases in oxidative metabolism despite the different capacities of these neuronal populations.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc19013176
003      
CZ-PrNML
005      
20191014135522.0
007      
ta
008      
190405s2018 xxu f 000 0|eng||
009      
AR
024    7_
$a 10.1177/0271678X17695291 $2 doi
035    __
$a (PubMed)28273721
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxu
100    1_
$a Bednařík, Petr, $d 1979- $7 mub2016934215 $u 1 Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN, USA. 2 Division of Endocrinology and Diabetes, Department of Medicine, University of Minnesota, Minneapolis, MN, USA. 3 CEITEC - Central European Institute of Technology, Masaryk University, Brno, Czech Republic.
245    10
$a Neurochemical responses to chromatic and achromatic stimuli in the human visual cortex / $c P. Bednařík, I. Tkáč, F. Giove, LE. Eberly, DK. Deelchand, FR. Barreto, S. Mangia,
520    9_
$a In the present study, we aimed at determining the metabolic responses of the human visual cortex during the presentation of chromatic and achromatic stimuli, known to preferentially activate two separate clusters of neuronal populations (called "blobs" and "interblobs") with distinct sensitivity to color or luminance features. Since blobs and interblobs have different cytochrome-oxidase (COX) content and micro-vascularization level (i.e., different capacities for glucose oxidation), different functional metabolic responses during chromatic vs. achromatic stimuli may be expected. The stimuli were optimized to evoke a similar load of neuronal activation as measured by the bold oxygenation level dependent (BOLD) contrast. Metabolic responses were assessed using functional 1H MRS at 7 T in 12 subjects. During both chromatic and achromatic stimuli, we observed the typical increases in glutamate and lactate concentration, and decreases in aspartate and glucose concentration, that are indicative of increased glucose oxidation. However, within the detection sensitivity limits, we did not observe any difference between metabolic responses elicited by chromatic and achromatic stimuli. We conclude that the higher energy demands of activated blobs and interblobs are supported by similar increases in oxidative metabolism despite the different capacities of these neuronal populations.
650    _2
$a kyselina asparagová $x metabolismus $7 D001224
650    _2
$a mozek - chemie $x fyziologie $7 D001923
650    12
$a barva $7 D003116
650    _2
$a respirační komplex IV $x metabolismus $7 D003576
650    _2
$a energetický metabolismus $7 D004734
650    _2
$a zrakové evokované potenciály $7 D005074
650    _2
$a glukosa $x metabolismus $7 D005947
650    _2
$a kyselina glutamová $x metabolismus $7 D018698
650    _2
$a zdraví dobrovolníci pro lékařské studie $7 D064368
650    _2
$a lidé $7 D006801
650    _2
$a kyselina mléčná $x metabolismus $7 D019344
650    _2
$a magnetická rezonanční tomografie $7 D008279
650    _2
$a magnetická rezonanční spektroskopie $7 D009682
650    _2
$a neurony $x fyziologie $7 D009474
650    _2
$a oxidace-redukce $7 D010084
650    12
$a světelná stimulace $7 D010775
650    _2
$a zrakové korové centrum $x metabolismus $x fyziologie $7 D014793
655    _2
$a časopisecké články $7 D016428
655    _2
$a Research Support, N.I.H., Extramural $7 D052061
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Tkáč, Ivan $u 1 Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN, USA.
700    1_
$a Giove, Federico $u 4 MARBILab, Museo storico della fisica e Centro di studi e ricerche Enrico Fermi, Rome, Italy. 5 Fondazione Santa Lucia IRCCS, Rome, Italy.
700    1_
$a Eberly, Lynn E $u 6 Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN, USA.
700    1_
$a Deelchand, Dinesh K $u 1 Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN, USA.
700    1_
$a Barreto, Felipe R $u 7 Physics Department, University of Sao Paulo, Ribeirao Preto, SP, Brazil.
700    1_
$a Mangia, Silvia $u 1 Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN, USA.
773    0_
$w MED00009982 $t Journal of cerebral blood flow and metabolism official journal of the International Society of Cerebral Blood Flow and Metabolism $x 1559-7016 $g Roč. 38, č. 2 (2018), s. 347-359
856    41
$u https://pubmed.ncbi.nlm.nih.gov/28273721 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20190405 $b ABA008
991    __
$a 20191014135946 $b ABA008
999    __
$a ok $b bmc $g 1392486 $s 1051481
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2018 $b 38 $c 2 $d 347-359 $e 20170224 $i 1559-7016 $m Journal of cerebral blood flow and metabolism $n J Cereb Blood Flow Metab $x MED00009982
LZP    __
$a Pubmed-20190405

Najít záznam

Citační ukazatele

Nahrávání dat ...

Možnosti archivace

Nahrávání dat ...