Detail
Article
Online article
FT
Medvik - BMC
  • Something wrong with this record ?

Cell membrane-derived microvesicles in systemic inflammatory response

M. Šibíková, J. Živný, J. Janota

. 2018 ; 64 (4) : 113-124.

Language English Country Czech Republic

Document type Journal Article, Review

Persistent link   https://www.medvik.cz/link/bmc19021851

Grant support
NV16-27800A MZ0 CEP Register

Human body reacts to physical, chemical and biological insults with a complex inflammatory reaction. Crucial components and executors of this response are endothelial cells, platelets, white blood cells, plasmatic coagulation system, and complement. Endothelial injury and inflammation are associated with elevated blood levels of cell membrane-derived microvesicles. Increased concentrations of microvesicles were found in several inflammatory reactions and diseases including acute coronary syndromes, stroke, vasculitis, venous thromboembolism, multiple sclerosis, rheumatoid arthritis, systemic lupus erythematosus, anti-phospholipid antibody syndrome, inflammatory bowel disease, thrombotic thrombocytopenic purpura, viral myocarditis, sepsis, disseminated intravascular coagulation, polytrauma, and burns. Microvesicles can modulate a variety of cellular processes, thereby having an impact on pathogenesis of diseases associated with inflammation. Microvesicles are important mediators and potential biomarkers of systemic inflammation. Measurement of inflammatory cell-derived microvesicles may be utilized in diagnostic algorithms and used for detection and determination of severity in diseases associated with inflammatory responses, as well as for prediction of their outcome. This review focuses on the mechanisms of release of microvesicles in diseases associated with systemic inflammation and their potential role in the regulation of cellular and humoral interactions.

000      
00000naa a2200000 a 4500
001      
bmc19021851
003      
CZ-PrNML
005      
20191105130245.0
007      
ta
008      
190607s2018 xr d f 000 0|eng||
009      
AR
035    __
$a (PubMed)30724157
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xr
100    1_
$a Šibíková, Michaela. $u Third Faculty of Medicine, First Faculty of Medicine, Charles University, Prague, Czech Republic $7 xx0237022
245    10
$a Cell membrane-derived microvesicles in systemic inflammatory response / $c M. Šibíková, J. Živný, J. Janota
520    9_
$a Human body reacts to physical, chemical and biological insults with a complex inflammatory reaction. Crucial components and executors of this response are endothelial cells, platelets, white blood cells, plasmatic coagulation system, and complement. Endothelial injury and inflammation are associated with elevated blood levels of cell membrane-derived microvesicles. Increased concentrations of microvesicles were found in several inflammatory reactions and diseases including acute coronary syndromes, stroke, vasculitis, venous thromboembolism, multiple sclerosis, rheumatoid arthritis, systemic lupus erythematosus, anti-phospholipid antibody syndrome, inflammatory bowel disease, thrombotic thrombocytopenic purpura, viral myocarditis, sepsis, disseminated intravascular coagulation, polytrauma, and burns. Microvesicles can modulate a variety of cellular processes, thereby having an impact on pathogenesis of diseases associated with inflammation. Microvesicles are important mediators and potential biomarkers of systemic inflammation. Measurement of inflammatory cell-derived microvesicles may be utilized in diagnostic algorithms and used for detection and determination of severity in diseases associated with inflammatory responses, as well as for prediction of their outcome. This review focuses on the mechanisms of release of microvesicles in diseases associated with systemic inflammation and their potential role in the regulation of cellular and humoral interactions.
650    _2
$a zvířata $7 D000818
650    _2
$a mikropartikule $x metabolismus $7 D055252
650    _2
$a lidé $7 D006801
650    _2
$a zánět $x krev $x patologie $7 D007249
650    _2
$a sepse $x patologie $7 D018805
650    _2
$a syndrom systémové zánětlivé reakce $x patologie $7 D018746
655    _2
$a časopisecké články $7 D016428
655    _2
$a přehledy $7 D016454
700    1_
$a Živný, Jan $u Institute of Pathological Physiology, First Faculty of Medicine, Charles University, Prague, Czech Republic $7 xx0115576
700    1_
$a Janota, Jan $7 stk2007405368 $u Institute of Pathological Physiology, First Faculty of Medicine, Charles University, Prague, Czech Republic; Department of Neonatology, Thomayer Hospital, Prague, Czech Republic
773    0_
$w MED00011004 $t Folia biologica $x 0015-5500 $g Roč. 64, č. 4 (2018), s. 113-124
856    41
$u https://pubmed.ncbi.nlm.nih.gov/30724157 $y Pubmed
856    41
$u https://fb.cuni.cz/file/5876/fb2018a0015.pdf $y plný text volně přístupný
910    __
$a ABA008 $b A 970 $c 89 $y 4 $z 0
990    __
$a 20190607 $b ABA008
991    __
$a 20191105130514 $b ABA008
999    __
$a ok $b bmc $g 1415466 $s 1060206
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2018 $b 64 $c 4 $d 113-124 $i 0015-5500 $m Folia biologica (Praha) $n Folia biol. (Praha) $x MED00011004
GRA    __
$a NV16-27800A $p MZ0
LZP    __
$b NLK118 $a Pubmed-20190607

Find record

Citation metrics

Archiving options