Detail
Article
Online article
FT
Medvik - BMC
  • Something wrong with this record ?

Expression of matrix metalloproteinases and endogenous Inhibitors in abdominal aortic aneurysm and aortoiliac occlusive disease (syndrome Leriche)

N. Vasic, S. Glumac, S. Pejic, LJ. Amidzic, LJ. Tadic Latinovic, B. Dozic, S. Hinic, Z. Maksimovic

. 2017 ; 63 (5-6) : 209-216. [pub] -

Language English Country Czech Republic

Document type Journal Article

Persistent link   https://www.medvik.cz/link/bmc19026292

Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) play a complex role in the pathogenesis of atherosclerosis. We compared (1) the histopathological findings in patients with abdominal aortic aneurysms (AAA) and aortoiliac occlusive disease (AOD); (2) the expression of MMP-2/MMP-9 and TIMP-1/TIMP-2 in aortic layers, inflammatory cells and smooth muscle cells (SMCs), aiming to identify the common underlying pathogenic mechanisms of the disease development. Samples were obtained from 30 patients with AAA and 30 with AOD. Aortic histology and immunohistochemistry were performed to evaluate inflammatory changes and MMP and TIMP expression. Thrombosis and ulceration were more frequent in AOD than in AAA. The MMP-9 expression was elevated in all aortic layers of AAA patients and in media/adventitia of AOD patients, mainly followed by lower expression of its inhibitor TIMP-1. Higher MMP-9 expression was also found in SMCs and macrophages of both AAA and AOD specimens, while higher TIMP-1/TIMP-2 were predominantly observed in the lymphocytes and macrophages of the aneurysm. These results showed that both conditions exhibited increased MMP-9 expression; however, the MMP expression pattern differed to some degree between the aneurysms and occlusive disease. The variations in molecular mechanisms underlying dilatative/stenosing disease warrant further investigation.

000      
00000naa a2200000 a 4500
001      
bmc19026292
003      
CZ-PrNML
005      
20190807100055.0
007      
ta
008      
190801s2017 xr a f 000 0|eng||
009      
AR
035    __
$a (PubMed)29687775
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xr
100    1_
$a Vasic, N. $u Department of Vascular Surgery; University Clinical Centre of the Republic of Srpska, Banja Luka, Bosnia and Herzegovina
245    10
$a Expression of matrix metalloproteinases and endogenous Inhibitors in abdominal aortic aneurysm and aortoiliac occlusive disease (syndrome Leriche) / $c N. Vasic, S. Glumac, S. Pejic, LJ. Amidzic, LJ. Tadic Latinovic, B. Dozic, S. Hinic, Z. Maksimovic
520    9_
$a Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) play a complex role in the pathogenesis of atherosclerosis. We compared (1) the histopathological findings in patients with abdominal aortic aneurysms (AAA) and aortoiliac occlusive disease (AOD); (2) the expression of MMP-2/MMP-9 and TIMP-1/TIMP-2 in aortic layers, inflammatory cells and smooth muscle cells (SMCs), aiming to identify the common underlying pathogenic mechanisms of the disease development. Samples were obtained from 30 patients with AAA and 30 with AOD. Aortic histology and immunohistochemistry were performed to evaluate inflammatory changes and MMP and TIMP expression. Thrombosis and ulceration were more frequent in AOD than in AAA. The MMP-9 expression was elevated in all aortic layers of AAA patients and in media/adventitia of AOD patients, mainly followed by lower expression of its inhibitor TIMP-1. Higher MMP-9 expression was also found in SMCs and macrophages of both AAA and AOD specimens, while higher TIMP-1/TIMP-2 were predominantly observed in the lymphocytes and macrophages of the aneurysm. These results showed that both conditions exhibited increased MMP-9 expression; however, the MMP expression pattern differed to some degree between the aneurysms and occlusive disease. The variations in molecular mechanisms underlying dilatative/stenosing disease warrant further investigation.
650    _2
$a aneurysma břišní aorty $x metabolismus $7 D017544
650    _2
$a nemoci aorty $x metabolismus $7 D001018
650    _2
$a arteriální okluzní nemoci $x metabolismus $7 D001157
650    _2
$a lidé $7 D006801
650    _2
$a imunohistochemie $7 D007150
650    _2
$a matrixová metaloproteinasa 9 $x metabolismus $7 D020780
650    _2
$a matrixové metaloproteinasy $x metabolismus $7 D020782
650    _2
$a myocyty hladké svaloviny $x metabolismus $7 D032389
650    _2
$a tkáňový inhibitor metaloproteinasy 1 $x metabolismus $7 D019715
650    _2
$a tkáňový inhibitor metaloproteinasy 2 $x metabolismus $7 D019716
655    _2
$a časopisecké články $7 D016428
700    1_
$a Glumac, S. $u Institute of Pathology, School of Medicine, University Clinical Hospital Centre "Bezanijska kosa"; University of Belgrade, Belgrade, Serbia
700    1_
$a Pejic, S. $u Laboratory for Molecular Biology and Endocrinology, "Vinca" Institute of Nuclear Sciences, University Clinical Hospital Centre "Bezanijska kosa"; University of Belgrade, Belgrade, Serbia
700    1_
$a Amidzic, L. J. $u Department of Clinical Pathology; University Clinical Centre of the Republic of Srpska, Banja Luka, Bosnia and Herzegovina
700    1_
$a Tadic Latinovic, L. J. $u Department of Clinical Pathology; University Clinical Centre of the Republic of Srpska, Banja Luka, Bosnia and Herzegovina
700    1_
$a Dozic, B. $u Institute of Pathology, School of Dental Medicine, University Clinical Hospital Centre "Bezanijska kosa"; University of Belgrade, Belgrade, Serbia
700    1_
$a Hinic, S. $u Department of Cardiology, University Clinical Hospital Centre "Bezanijska kosa"; University of Belgrade, Belgrade, Serbia
700    1_
$a Maksimovic, Z. $u Clinic for Vascular and Endovascular Surgery, Serbian Clinical Centre; University of Belgrade, Belgrade, Serbia
773    0_
$w MED00011004 $t Folia biologica $x 0015-5500 $g Roč. 63, č. 5-6 (2017), s. 209-216
856    41
$u https://pubmed.ncbi.nlm.nih.gov/29687775 $y Pubmed
856    41
$u https://fb.cuni.cz/file/5858/fb2017a0029.pdf $y plný text volně přístupný
910    __
$a ABA008 $b A 970 $c 89 $y 4 $z 0
990    __
$a 20190801 $b ABA008
991    __
$a 20190805153337 $b ABA008
999    __
$a ok $b bmc $g 1430042 $s 1064724
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2017 $b 63 $c 5-6 $d 209-216 $e - $i 0015-5500 $m Folia biologica (Praha) $n Folia biol. (Praha) $x MED00011004
LZP    __
$b NLK111 $a Pubmed-20190801

Find record

Citation metrics

Archiving options