• Je něco špatně v tomto záznamu ?

Counterattacking the tick bite: towards a rational design of anti-tick vaccines targeting pathogen transmission

ROM. Rego, JJA. Trentelman, J. Anguita, AM. Nijhof, H. Sprong, B. Klempa, O. Hajdusek, J. Tomás-Cortázar, T. Azagi, M. Strnad, S. Knorr, R. Sima, M. Jalovecka, S. Fumačová Havlíková, M. Ličková, M. Sláviková, P. Kopacek, L. Grubhoffer, JW. Hovius,

. 2019 ; 12 (1) : 229. [pub] 20190514

Jazyk angličtina Země Anglie, Velká Británie

Typ dokumentu časopisecké články, přehledy

Perzistentní odkaz   https://www.medvik.cz/link/bmc19027619

Grantová podpora
602272-2 FP7 Health
17-21244S Grantová Agentura České Republiky
17-27386S Grantová Agentura České Republiky
17-27393S Grantová Agentura České Republiky
2/0191/17 Slovenská Akadémia Vied
522003007 ZonMW

Hematophagous arthropods are responsible for the transmission of a variety of pathogens that cause disease in humans and animals. Ticks of the Ixodes ricinus complex are vectors for some of the most frequently occurring human tick-borne diseases, particularly Lyme borreliosis and tick-borne encephalitis virus (TBEV). The search for vaccines against these diseases is ongoing. Efforts during the last few decades have primarily focused on understanding the biology of the transmitted viruses, bacteria and protozoans, with the goal of identifying targets for intervention. Successful vaccines have been developed against TBEV and Lyme borreliosis, although the latter is no longer available for humans. More recently, the focus of intervention has shifted back to where it was initially being studied which is the vector. State of the art technologies are being used for the identification of potential vaccine candidates for anti-tick vaccines that could be used either in humans or animals. The study of the interrelationship between ticks and the pathogens they transmit, including mechanisms of acquisition, persistence and transmission have come to the fore, as this knowledge may lead to the identification of critical elements of the pathogens' life-cycle that could be targeted by vaccines. Here, we review the status of our current knowledge on the triangular relationships between ticks, the pathogens they carry and the mammalian hosts, as well as methods that are being used to identify anti-tick vaccine candidates that can prevent the transmission of tick-borne pathogens.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc19027619
003      
CZ-PrNML
005      
20190815105527.0
007      
ta
008      
190813s2019 enk f 000 0|eng||
009      
AR
024    7_
$a 10.1186/s13071-019-3468-x $2 doi
035    __
$a (PubMed)31088506
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a enk
100    1_
$a Rego, Ryan O M $u Biology Centre, Institute of Parasitology, Czech Academy of Sciences, Branišovská 31, 37005, Ceske Budejovice, Czech Republic. ryanrego@paru.cas.cz.
245    10
$a Counterattacking the tick bite: towards a rational design of anti-tick vaccines targeting pathogen transmission / $c ROM. Rego, JJA. Trentelman, J. Anguita, AM. Nijhof, H. Sprong, B. Klempa, O. Hajdusek, J. Tomás-Cortázar, T. Azagi, M. Strnad, S. Knorr, R. Sima, M. Jalovecka, S. Fumačová Havlíková, M. Ličková, M. Sláviková, P. Kopacek, L. Grubhoffer, JW. Hovius,
520    9_
$a Hematophagous arthropods are responsible for the transmission of a variety of pathogens that cause disease in humans and animals. Ticks of the Ixodes ricinus complex are vectors for some of the most frequently occurring human tick-borne diseases, particularly Lyme borreliosis and tick-borne encephalitis virus (TBEV). The search for vaccines against these diseases is ongoing. Efforts during the last few decades have primarily focused on understanding the biology of the transmitted viruses, bacteria and protozoans, with the goal of identifying targets for intervention. Successful vaccines have been developed against TBEV and Lyme borreliosis, although the latter is no longer available for humans. More recently, the focus of intervention has shifted back to where it was initially being studied which is the vector. State of the art technologies are being used for the identification of potential vaccine candidates for anti-tick vaccines that could be used either in humans or animals. The study of the interrelationship between ticks and the pathogens they transmit, including mechanisms of acquisition, persistence and transmission have come to the fore, as this knowledge may lead to the identification of critical elements of the pathogens' life-cycle that could be targeted by vaccines. Here, we review the status of our current knowledge on the triangular relationships between ticks, the pathogens they carry and the mammalian hosts, as well as methods that are being used to identify anti-tick vaccine candidates that can prevent the transmission of tick-borne pathogens.
650    _2
$a zvířata $7 D000818
650    _2
$a proteiny členovců $x imunologie $7 D060829
650    _2
$a Borrelia $7 D001898
650    _2
$a infekce přenášené vektorem $7 D004199
650    _2
$a viry klíšťové encefalitidy $7 D004669
650    _2
$a klíšťová encefalitida $x prevence a kontrola $7 D004675
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a lidé $7 D006801
650    _2
$a klíště $x mikrobiologie $x virologie $7 D018884
650    _2
$a lymeská nemoc $x prevence a kontrola $7 D008193
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a sliny $7 D012463
650    _2
$a kousnutí klíštětem $x prevence a kontrola $7 D064927
650    _2
$a nemoci přenášené klíšťaty $x prevence a kontrola $x přenos $7 D017282
650    _2
$a vakcíny $x imunologie $7 D014612
655    _2
$a časopisecké články $7 D016428
655    _2
$a přehledy $7 D016454
700    1_
$a Trentelman, Jos J A $u Amsterdam UMC, Location AMC, Center for Experimental and Molecular Medicine, Amsterdam, The Netherlands.
700    1_
$a Anguita, Juan $u CIC bioGUNE, 48160, Derio, Spain. Ikerbasque, Basque Foundation for Science, 48012, Bilbao, Spain.
700    1_
$a Nijhof, Ard M $u Institute for Parasitology and Tropical Veterinary Medicine, Freie Universität Berlin, Berlin, Germany.
700    1_
$a Sprong, Hein $u Centre for Zoonoses and Environmental Microbiology, Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands.
700    1_
$a Klempa, Boris $u Institute of Virology, Biomedical Research Center of the Slovak Academy of Sciences, Bratislava, Slovakia.
700    1_
$a Hajdusek, Ondrej $u Biology Centre, Institute of Parasitology, Czech Academy of Sciences, Branišovská 31, 37005, Ceske Budejovice, Czech Republic.
700    1_
$a Tomás-Cortázar, Julen $u CIC bioGUNE, 48160, Derio, Spain.
700    1_
$a Azagi, Tal $u Centre for Zoonoses and Environmental Microbiology, Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands.
700    1_
$a Strnad, Martin $u Biology Centre, Institute of Parasitology, Czech Academy of Sciences, Branišovská 31, 37005, Ceske Budejovice, Czech Republic. Faculty of Science, University of South Bohemia, Branišovská 31, 37005, Ceske Budejovice, Czech Republic.
700    1_
$a Knorr, Sarah $u Institute for Parasitology and Tropical Veterinary Medicine, Freie Universität Berlin, Berlin, Germany.
700    1_
$a Sima, Radek $u Biology Centre, Institute of Parasitology, Czech Academy of Sciences, Branišovská 31, 37005, Ceske Budejovice, Czech Republic.
700    1_
$a Jalovecka, Marie $u Biology Centre, Institute of Parasitology, Czech Academy of Sciences, Branišovská 31, 37005, Ceske Budejovice, Czech Republic. Faculty of Science, University of South Bohemia, Branišovská 31, 37005, Ceske Budejovice, Czech Republic.
700    1_
$a Fumačová Havlíková, Sabína $u Institute of Virology, Biomedical Research Center of the Slovak Academy of Sciences, Bratislava, Slovakia.
700    1_
$a Ličková, Martina $u Institute of Virology, Biomedical Research Center of the Slovak Academy of Sciences, Bratislava, Slovakia.
700    1_
$a Sláviková, Monika $u Institute of Virology, Biomedical Research Center of the Slovak Academy of Sciences, Bratislava, Slovakia.
700    1_
$a Kopacek, Petr $u Biology Centre, Institute of Parasitology, Czech Academy of Sciences, Branišovská 31, 37005, Ceske Budejovice, Czech Republic. Faculty of Science, University of South Bohemia, Branišovská 31, 37005, Ceske Budejovice, Czech Republic.
700    1_
$a Grubhoffer, Libor $u Biology Centre, Institute of Parasitology, Czech Academy of Sciences, Branišovská 31, 37005, Ceske Budejovice, Czech Republic. Faculty of Science, University of South Bohemia, Branišovská 31, 37005, Ceske Budejovice, Czech Republic.
700    1_
$a Hovius, Joppe W $u Amsterdam UMC, Location AMC, Center for Experimental and Molecular Medicine, Amsterdam, The Netherlands.
773    0_
$w MED00165371 $t Parasites & vectors $x 1756-3305 $g Roč. 12, č. 1 (2019), s. 229
856    41
$u https://pubmed.ncbi.nlm.nih.gov/31088506 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20190813 $b ABA008
991    __
$a 20190815105755 $b ABA008
999    __
$a ok $b bmc $g 1432768 $s 1066079
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2019 $b 12 $c 1 $d 229 $e 20190514 $i 1756-3305 $m Parasites & vectors $n Parasit Vectors $x MED00165371
GRA    __
$a 602272-2 $p FP7 Health
GRA    __
$a 17-21244S $p Grantová Agentura České Republiky
GRA    __
$a 17-27386S $p Grantová Agentura České Republiky
GRA    __
$a 17-27393S $p Grantová Agentura České Republiky
GRA    __
$a 2/0191/17 $p Slovenská Akadémia Vied
GRA    __
$a 522003007 $p ZonMW
LZP    __
$a Pubmed-20190813

Najít záznam

Citační ukazatele

Možnosti archivace