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Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard
P. Andrade, C. Pinho, G. Pérez I de Lanuza, S. Afonso, J. Brejcha, CJ. Rubin, O. Wallerman, P. Pereira, SJ. Sabatino, A. Bellati, D. Pellitteri-Rosa, Z. Bosakova, I. Bunikis, MA. Carretero, N. Feiner, P. Marsik, F. Paupério, D. Salvi, L. Soler,...
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, práce podpořená grantem
NLK
Free Medical Journals
od 1915 do Před 6 měsíci
Freely Accessible Science Journals
od 1915 do Před 6 měsíci
PubMed Central
od 1915 do Před 6 měsíci
Europe PubMed Central
od 1915 do Před 6 měsíci
Open Access Digital Library
od 1915-01-01
Open Access Digital Library
od 1915-01-15
PubMed
30819892
DOI
10.1073/pnas.1820320116
Knihovny.cz E-zdroje
- MeSH
- alkoholoxidoreduktasy genetika fyziologie MeSH
- barva MeSH
- dioxygenasy genetika MeSH
- ještěři genetika metabolismus MeSH
- karotenoidy genetika metabolismus MeSH
- pigmentace kůže genetika MeSH
- pigmentace genetika MeSH
- polymorfismus genetický genetika MeSH
- pteriny metabolismus MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
Reptiles use pterin and carotenoid pigments to produce yellow, orange, and red colors. These conspicuous colors serve a diversity of signaling functions, but their molecular basis remains unresolved. Here, we show that the genomes of sympatric color morphs of the European common wall lizard (Podarcis muralis), which differ in orange and yellow pigmentation and in their ecology and behavior, are virtually undifferentiated. Genetic differences are restricted to two small regulatory regions near genes associated with pterin [sepiapterin reductase (SPR)] and carotenoid [beta-carotene oxygenase 2 (BCO2)] metabolism, demonstrating that a core gene in the housekeeping pathway of pterin biosynthesis has been coopted for bright coloration in reptiles and indicating that these loci exert pleiotropic effects on other aspects of physiology. Pigmentation differences are explained by extremely divergent alleles, and haplotype analysis revealed abundant transspecific allele sharing with other lacertids exhibiting color polymorphisms. The evolution of these conspicuous color ornaments is the result of ancient genetic variation and cross-species hybridization.
Departamento de Biologia Faculdade de Ciências Universidade do Porto 4169 007 Porto Portugal
Department of Biology Lund University 223 62 Lund Sweden
Department of Earth and Environmental Sciences University of Pavia 27100 Pavia Italy
Science for Life Laboratory National Bioinformatics Infrastructure Sweden 751 23 Uppsala Sweden
Citace poskytuje Crossref.org
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- $a Andrade, Pedro $u CIBIO/InBIO, Centro de Investigação em Biodiversidade e Recursos Genéticos, Universidade do Porto, 4485-661 Vairão, Portugal. Departamento de Biologia, Faculdade de Ciências, Universidade do Porto, 4169-007 Porto, Portugal.
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