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Fluorine-containing block/branched polyamphiphiles forming bioinspired complexes with biopolymers

O. Paiuk, N. Mitina, M. Slouf, E. Pavlova, N. Finiuk, N. Kinash, A. Karkhut, N. Manko, T. Gromovoy, O. Hevus, Y. Shermolovich, R. Stoika, A. Zaichenko,

. 2019 ; 174 (-) : 393-400. [pub] 20181120

Language English Country Netherlands

Document type Journal Article

Persistent link   https://www.medvik.cz/link/bmc19028037

Colloidal-chemical characteristics of block/branched cationic and non-ionic polyamphiphiles containing poly(fluorine-alkyl methacrylate) (poly(FMA)) block and their intermolecular complexes with biopolymers were studied. The dependences of their surface activity and micelle size on the length of hydrophobic and hydrophilic blocks, as well as the length of side fluorine-alkyl branches were established. Poly(FMA)-block-poly(DMAEMA) was used for formation of interpolyelectrolyte complexes with plasmid DNA (pDNA) via their electrostatic interaction. Novel non-viral polyplexes were tested as gene delivery systems for mammalian cells. The results of DLS, TEM and MALDI-ToF studies demonstrated disaggregation of lysozyme (LYZ) aggregates in the presence of poly(FMA)-block-poly(NVP) and formation of the polyamphiphile…LYS complex possessing antibacterial action.

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$a Colloidal-chemical characteristics of block/branched cationic and non-ionic polyamphiphiles containing poly(fluorine-alkyl methacrylate) (poly(FMA)) block and their intermolecular complexes with biopolymers were studied. The dependences of their surface activity and micelle size on the length of hydrophobic and hydrophilic blocks, as well as the length of side fluorine-alkyl branches were established. Poly(FMA)-block-poly(DMAEMA) was used for formation of interpolyelectrolyte complexes with plasmid DNA (pDNA) via their electrostatic interaction. Novel non-viral polyplexes were tested as gene delivery systems for mammalian cells. The results of DLS, TEM and MALDI-ToF studies demonstrated disaggregation of lysozyme (LYZ) aggregates in the presence of poly(FMA)-block-poly(NVP) and formation of the polyamphiphile…LYS complex possessing antibacterial action.
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$a Mitina, Nataliya $u Lviv Polytechnic National University, S. Bandery str., 12, 79013, Lviv, Ukraine.
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$a Slouf, Miroslav $u Institute of Macromolecular Chemistry, Czech Academy of Sciences, Heyrovskeho nam. 2, 16206 Prague 6, Czech Republic.
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$a Pavlova, Ewa $u Institute of Macromolecular Chemistry, Czech Academy of Sciences, Heyrovskeho nam. 2, 16206 Prague 6, Czech Republic.
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$a Finiuk, Nataliya $u Institute of Cell Biology, NAS of Ukraine, Drahomanova str., 14/16, 79005, Lviv, Ukraine.
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$a Gromovoy, Taras $u Chuiko Institute of Surface Chemistry, NAS of Ukraine, Naumova str. 17, 03164, Kyiv, Ukraine.
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