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Interleukin-6: a molecule with complex biological impact in cancer

L. Lacina, J. Brábek, V. Král, O. Kodet, K. Smetana,

. 2019 ; 34 (2) : 125-136. [pub] 20180904

Jazyk angličtina Země Španělsko

Typ dokumentu časopisecké články, přehledy

Perzistentní odkaz   https://www.medvik.cz/link/bmc19028234

Grantová podpora
16-05534S Grant Agency of the Czech Republic
15-28933A Ministry of Health of the Czech Republic
16-29032A Ministry of Health of the Czech Republic
CZ.1.05/1.1.00/02.0109 BIOCEV
LQ1604 BIOCEV-FAR
NV15-28933A MZ0 CEP - Centrální evidence projektů
NV16-29032A MZ0 CEP - Centrální evidence projektů

Interleukin-6 is a multifaceted cytokine, usually reported as a pro-inflammatory molecule. However, certain anti-inflammatory activities were also attributed to IL-6. The levels of IL-6 in serum as well as in other biological fluids are elevated in an age-dependent manner. Notably, it is consistently reported also as a key feature of the senescence-associated secretory phenotype. In the elderly, this cytokine participates in the initiation of catabolism resulting in, e.g. sarcopenia. It can cross the blood-brain barrier, and so it is in causal association with, e.g. depression, bipolar disorder, schizophrenia, and anorexia. In the cancer patient, IL-6 is produced by cancer and stromal cells and actively participates in their crosstalk. IL-6 supports tumour growth and metastasising in terminal patients, and it significantly engages in cancer cachexia (including anorexia) and depression associated with malignancy. The pharmacological treatment impairing IL-6 signalling represents a potential mechanism of anti-tumour therapy targeting cancer growth, metastatic spread, metabolic deterioration and terminal cachexia in patients.

Citace poskytuje Crossref.org

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