The treatment of some inborn metabolism errors requires cholesterol substitution therapy. Cholesterol plays a vital role in the human body. Therefore, the majority of cholesterol determination techniques are targeted to blood and blood serum. Nevertheless, cholesterol determination in food is important as well. In this paper, cholesterol determination using differential pulse voltammetry (DPV) in dairy products (e.g., milk, clotted cream, yogurt, butter, etc.) is reported with a novel nonenzymatic sensor based on diphosphonic acid of 1,4-diacetylglycoluril (DPADGU) as an electrode surface modifier. Stable anodic response was obtained from cholesterol on the modified carbon-based electrode. The sensor has high stability, sensitivity (20 μA mol L-1 cm-2), and a wide linear range from 1 up to 200 μM. The LOD and LOQ values are 1.5 and 5.1 μM, respectively. The developed methods were successfully applied to the above mentioned dairy products. Graphical abstract ᅟ.

Department of Organic Chemistry and Polymers Faculty of Chemistry Karaganda State University Universitetskaya St 28 Karaganda Kazakhstan 100028

Physical and Analytical Chemistry Department Institute of Natural Resources Tomsk Polytechnic University Lenin av 30 634050 Tomsk Russia

Physical and Analytical Chemistry Department Institute of Natural Resources Tomsk Polytechnic University Lenin av 30 634050 Tomsk Russia Department of Solid State Chemistry University of Chemistry and Technology Technická 5 166 28 Prague 6 Czech Republic

Physical and Analytical Chemistry Department Institute of Natural Resources Tomsk Polytechnic University Lenin av 30 634050 Tomsk Russia Faculty of Science Department of Analytical Chemistry UNESCO Laboratory of Environmental Electrochemistry Charles University Albertov 6 128 43 Prague 2 Czech Republic

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