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Late preterm prelabor rupture of fetal membranes: fetal inflammatory response and neonatal outcome
I. Musilova, C. Andrys, M. Drahosova, B. Zednikova, H. Hornychova, L. Pliskova, H. Zemlickova, B. Jacobsson, M. Kacerovsky,
Language English Country United States
Document type Journal Article, Research Support, Non-U.S. Gov't
NLK
Free Medical Journals
from 1967 to 1 year ago
ProQuest Central
from 2016-01-01 to 1 year ago
Health & Medicine (ProQuest)
from 2016-01-01 to 1 year ago
Public Health Database (ProQuest)
from 2016-01-01 to 1 year ago
PubMed
29186106
DOI
10.1038/pr.2017.300
Knihovny.cz E-resources
- MeSH
- Chlamydia trachomatis MeSH
- Chorioamnionitis microbiology MeSH
- Adult MeSH
- Enzyme-Linked Immunosorbent Assay MeSH
- Fetal Blood chemistry MeSH
- Gestational Age MeSH
- Interleukin-6 blood MeSH
- Humans MeSH
- Mycoplasma hominis MeSH
- Infant, Newborn MeSH
- Placenta pathology MeSH
- Amniotic Fluid microbiology MeSH
- Fetal Membranes, Premature Rupture microbiology MeSH
- Prospective Studies MeSH
- Pregnancy MeSH
- Ureaplasma metabolism MeSH
- Vasculitis microbiology MeSH
- Pregnancy Outcome MeSH
- Inflammation microbiology MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Infant, Newborn MeSH
- Pregnancy MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
BackgroundTo characterize the influence of microbial invasion of the amniotic cavity (MIAC) and/or intra-amniotic inflammation (IAI) on the intensity of the fetal inflammatory response and the association between the presence of the fetal inflammatory response syndrome (FIRS) and short-term neonatal morbidity in the preterm prelabor rupture of membranes (PPROM) between the gestational ages of 34 and 37 weeks.MethodsOne hundred and fifty-nine women were included in the study. The umbilical cord blood interleukin (IL)-6 concentrations were determined using enzyme-linked immunosorbent assay kits. FIRS was defined based on the umbilical cord blood IL-6 concentration and the presence of funisitis and/or chorionic plate vasculitis.ResultsWomen with both MIAC and IAI had the highest median umbilical cord blood IL-6 concentrations and highest rates of FIRS. Women with FIRS had the higher rates of early-onset sepsis and intraventricular hemorrhage grades I and II when FIRS was characterized based on the umbilical cord blood IL-6 concentrations and the histopathological findings.ConclusionThe presence of both MIAC and IAI was associated with a higher fetal inflammatory response and a higher rate of FIRS. Different aspects of short-term neonatal morbidity were related to FIRS when defined by umbilical cord blood IL-6 concentrations and the histopathology of the placenta.
References provided by Crossref.org
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- $a BackgroundTo characterize the influence of microbial invasion of the amniotic cavity (MIAC) and/or intra-amniotic inflammation (IAI) on the intensity of the fetal inflammatory response and the association between the presence of the fetal inflammatory response syndrome (FIRS) and short-term neonatal morbidity in the preterm prelabor rupture of membranes (PPROM) between the gestational ages of 34 and 37 weeks.MethodsOne hundred and fifty-nine women were included in the study. The umbilical cord blood interleukin (IL)-6 concentrations were determined using enzyme-linked immunosorbent assay kits. FIRS was defined based on the umbilical cord blood IL-6 concentration and the presence of funisitis and/or chorionic plate vasculitis.ResultsWomen with both MIAC and IAI had the highest median umbilical cord blood IL-6 concentrations and highest rates of FIRS. Women with FIRS had the higher rates of early-onset sepsis and intraventricular hemorrhage grades I and II when FIRS was characterized based on the umbilical cord blood IL-6 concentrations and the histopathological findings.ConclusionThe presence of both MIAC and IAI was associated with a higher fetal inflammatory response and a higher rate of FIRS. Different aspects of short-term neonatal morbidity were related to FIRS when defined by umbilical cord blood IL-6 concentrations and the histopathology of the placenta.
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