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Recovery of Infectious Hepatitis C Virus From Injection Paraphernalia: Implications for Prevention Programs Serving People Who Inject Drugs
R. Heimer, M. Binka, S. Koester, JC. Grund, A. Patel, E. Paintsil, BD. Lindenbach,
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, Research Support, N.I.H., Extramural
Grantová podpora
UL1 TR001863
NCATS NIH HHS - United States
NLK
Free Medical Journals
od 1997 do Před 1 rokem
Open Access Digital Library
od 1997-04-01
PubMed
28968665
DOI
10.1093/infdis/jix427
Knihovny.cz E-zdroje
- MeSH
- Hepacivirus izolace a purifikace fyziologie MeSH
- hepatitida C přenos MeSH
- injekční stříkačky virologie MeSH
- intravenózní abúzus drog komplikace MeSH
- lidé MeSH
- mikrobiální viabilita * MeSH
- mikrobiologie životního prostředí * MeSH
- přenos infekční nemoci MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- Research Support, N.I.H., Extramural MeSH
Background: Controlling hepatitis C virus (HCV) transmission among people who inject drugs (PWID) has focused on preventing sharing syringes and drug preparation paraphernalia, but it is unclear whether HCV incidence linked to sharing paraphernalia reflects contamination of the paraphernalia or syringe-mediated contamination when drugs are shared. Methods: In experiments designed to replicate real-world injection practices when drugs are shared, the residual contents of HCV-contaminated syringes with detachable or fixed needled were passed through the "cookers" and filters used by PWID in preparing drugs for injection and then introduced into a second syringe. All items were tested for the presence of infectious HCV using a chimeric HCV with a luciferase gene. Results: Hepatitis C virus could not be recovered from cookers regardless of input syringe type or cooker design. Recovery was higher when comparing detachable needles to fixed needles for residue in input syringes (73.8% vs 0%), filters (15.4% vs 1.4%), and receptive syringes (93.8% vs 45.7%). Conclusions: Our results, consistent with the hypothesis that sharing paraphernalia does not directly result in HCV transmission but is a surrogate for transmissions resulting from sharing drugs, have important implications for HCV prevention efforts and programs that provide education and safe injection supplies for PWID populations.
Department of Anthropology University of Colorado Denver
Department of Microbial Pathogenesis Yale University School of Medicine New Haven Connecticut
Citace poskytuje Crossref.org
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