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Cortical abnormalities in bipolar disorder: an MRI analysis of 6503 individuals from the ENIGMA Bipolar Disorder Working Group
DP. Hibar, LT. Westlye, NT. Doan, N. Jahanshad, JW. Cheung, CRK. Ching, A. Versace, AC. Bilderbeck, A. Uhlmann, B. Mwangi, B. Krämer, B. Overs, CB. Hartberg, C. Abé, D. Dima, D. Grotegerd, E. Sprooten, E. Bøen, E. Jimenez, FM. Howells, G....
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články, Research Support, N.I.H., Extramural, práce podpořená grantem
Grantová podpora
K23 MH074644
NIMH NIH HHS - United States
P41 EB015922
NIBIB NIH HHS - United States
K23 MH098130
NIMH NIH HHS - United States
R01 MH095454
NIMH NIH HHS - United States
106469
CIHR - Canada
R01 MH104284
NIMH NIH HHS - United States
K08 MH086786
NIMH NIH HHS - United States
142255
CIHR - Canada
P30 NS062691
NINDS NIH HHS - United States
R01 MH101111
NIMH NIH HHS - United States
MR/J008915/1
Medical Research Council - United Kingdom
U54 EB020403
NIBIB NIH HHS - United States
103703
CIHR - Canada
K01 MH096077
NIMH NIH HHS - United States
K23 MH085096
NIMH NIH HHS - United States
R01 MH075007
NIMH NIH HHS - United States
Wellcome Trust - United Kingdom
64410
CIHR - Canada
R01 MH107703
NIMH NIH HHS - United States
R01 MH085667
NIMH NIH HHS - United States
R01 MH090553
NIMH NIH HHS - United States
R01 MH076971
NIMH NIH HHS - United States
NLK
ProQuest Central
od 2000-01-01 do Před 1 rokem
Open Access Digital Library
od 1997-01-01
Health & Medicine (ProQuest)
od 2000-01-01 do Před 1 rokem
Psychology Database (ProQuest)
od 2000-01-01 do Před 1 rokem
PubMed
28461699
DOI
10.1038/mp.2017.73
Knihovny.cz E-zdroje
- MeSH
- bipolární porucha diagnostické zobrazování metabolismus patologie MeSH
- čelní lalok patologie MeSH
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- magnetická rezonanční tomografie metody MeSH
- mladiství MeSH
- mladý dospělý MeSH
- mozek patologie MeSH
- mozková kůra patofyziologie MeSH
- neurozobrazování MeSH
- prefrontální mozková kůra patologie MeSH
- psychotické poruchy patologie MeSH
- šedá hmota patologie MeSH
- sexuální faktory MeSH
- spánkový lalok patologie MeSH
- studie případů a kontrol MeSH
- věkové faktory MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Research Support, N.I.H., Extramural MeSH
Despite decades of research, the pathophysiology of bipolar disorder (BD) is still not well understood. Structural brain differences have been associated with BD, but results from neuroimaging studies have been inconsistent. To address this, we performed the largest study to date of cortical gray matter thickness and surface area measures from brain magnetic resonance imaging scans of 6503 individuals including 1837 unrelated adults with BD and 2582 unrelated healthy controls for group differences while also examining the effects of commonly prescribed medications, age of illness onset, history of psychosis, mood state, age and sex differences on cortical regions. In BD, cortical gray matter was thinner in frontal, temporal and parietal regions of both brain hemispheres. BD had the strongest effects on left pars opercularis (Cohen's d=-0.293; P=1.71 × 10-21), left fusiform gyrus (d=-0.288; P=8.25 × 10-21) and left rostral middle frontal cortex (d=-0.276; P=2.99 × 10-19). Longer duration of illness (after accounting for age at the time of scanning) was associated with reduced cortical thickness in frontal, medial parietal and occipital regions. We found that several commonly prescribed medications, including lithium, antiepileptic and antipsychotic treatment showed significant associations with cortical thickness and surface area, even after accounting for patients who received multiple medications. We found evidence of reduced cortical surface area associated with a history of psychosis but no associations with mood state at the time of scanning. Our analysis revealed previously undetected associations and provides an extensive analysis of potential confounding variables in neuroimaging studies of BD.
Bipolar Center Wiener Neustadt Wiener Neustadt Austria
Centre for Affective Disorders King's College London London UK
Department of Adult Psychiatry Poznan University of Medical Sciences Poznan Poland
Department of Clinical Neuroscience Osher Centre Karolinska Institutet Stockholm Sweden
Department of Clinical Radiology University of Münster Münster Germany
Department of Psychiatric Research Diakonhjemmet Hospital Oslo Norway
Department of Psychiatry and Human Behavior University of California Irvine CA USA
Department of Psychiatry and Mental Health University of Cape Town Cape Town South Africa
Department of Psychiatry and Psychotherapy University Medical Center Göttingen Göttingen Germany
Department of Psychiatry Dalhousie University Halifax NS Canada
Department of Psychiatry Faculty of Medicine University of São Paulo São Paulo Brazil
Department of Psychiatry Icahn School of Medicine at Mount Sinai New York NY USA
Department of Psychiatry University of Adelaide Adelaide SA Australia
Department of Psychiatry University of Münster Münster Germany
Department of Psychiatry University of Pennsylvania Philadelphia PA USA
Department of Psychiatry University of Pittsburgh School of Medicine Pittsburgh PA USA
Department of Psychiatry VU University Medical Center Amsterdam The Netherlands
Department of Psychology University of Exeter Exeter UK
Division of Psychiatry University of Edinburgh Edinburgh UK
Hospital Clinic IDIBAPS University of Barcelona CIBERSAM Barcelona Spain
Institute of Psychiatry Psychology and Neuroscience King's College London London UK
IRCCS E Medea Scientific Institute San Vito al Tagliamento Italy
Janssen Research and Development Titusville NJ USA
MRC Centre for Neuropsychiatric Genetics and Genomics Cardiff University Cardiff UK
Neuroscience Research Australia Sydney NSW Australia
School of Psychiatry and Black Dog Institute University of New South Wales Sydney NSW Australia
Citace poskytuje Crossref.org
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