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Metabolism of obeticholic acid in brown bullhead (Ameiurus nebulosus)
S. Mach, A. Jegorov, Z. Šimek,
Language English Country Germany
Document type Journal Article
NLK
ProQuest Central
from 1997-03-01 to 1 year ago
Health & Medicine (ProQuest)
from 1997-03-01 to 1 year ago
Public Health Database (ProQuest)
from 1997-03-01 to 1 year ago
- MeSH
- Water Pollutants, Chemical pharmacokinetics toxicity MeSH
- Ecotoxicology methods MeSH
- Glycine metabolism MeSH
- Mass Spectrometry MeSH
- Ictaluridae metabolism MeSH
- Chenodeoxycholic Acid analogs & derivatives analysis pharmacokinetics toxicity MeSH
- Taurine metabolism MeSH
- Chromatography, High Pressure Liquid MeSH
- Bile chemistry MeSH
- Animals MeSH
- Check Tag
- Animals MeSH
- Publication type
- Journal Article MeSH
Analysis of brown bullhead (Ameiurus nebulosus) bile by ultra performance liquid chromatography high-resolution mass spectrometry (UPLC/HRMS) revealed a series of bile acids similar to those found in humans. Accordingly, we chose this fish as a model organism to examine the metabolism of obeticholic acid, a bile acid used to treat a number of human liver diseases and the one that has the potential to occur as an environmental contaminant. The taurine and glycine conjugates of obeticholic acid and keto-obeticholic acid were identified, as well as the D-cysteinolic acid conjugate of obeticholic acid, likely a metabolite specific to fish. In addition, metabolites of obeticholic acid (sulphate and glucuronide) and several hydroxy-obeticholic acid derivatives were found, representing typical pathways of primary and secondary steroid metabolism. Brown bullhead exposed to obeticholic acid at a dose of 100 mg/kg gave no overt signs of distress or toxicity.
RECETOX Masaryk University Brno Kamenice 126 3 625 00 Brno Czech Republic
Teva Czech Industries s r o Ostravská 29 747 70 Opava Czech Republic
References provided by Crossref.org
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- $a Analysis of brown bullhead (Ameiurus nebulosus) bile by ultra performance liquid chromatography high-resolution mass spectrometry (UPLC/HRMS) revealed a series of bile acids similar to those found in humans. Accordingly, we chose this fish as a model organism to examine the metabolism of obeticholic acid, a bile acid used to treat a number of human liver diseases and the one that has the potential to occur as an environmental contaminant. The taurine and glycine conjugates of obeticholic acid and keto-obeticholic acid were identified, as well as the D-cysteinolic acid conjugate of obeticholic acid, likely a metabolite specific to fish. In addition, metabolites of obeticholic acid (sulphate and glucuronide) and several hydroxy-obeticholic acid derivatives were found, representing typical pathways of primary and secondary steroid metabolism. Brown bullhead exposed to obeticholic acid at a dose of 100 mg/kg gave no overt signs of distress or toxicity.
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