Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

Common variable immunodeficiency patients display elevated plasma levels of granulocyte activation markers elastase and myeloperoxidase

J. Litzman, Z. Chovancová, P. Bejdák, M. Litzman, Z. Hel, M. Vlková,

. 2019 ; 33 (-) : 2058738419843381. [pub] -

Jazyk angličtina Země Anglie, Velká Británie

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc19034644

Grantová podpora
NV15-28732A MZ0 CEP - Centrální evidence projektů

Common variable immunodeficiency disorders (CVIDs) represent a group of primary immunodeficiency diseases characterized by hypogammaglobulinemia and dysfunctional immune response to invading pathogens. Previous studies have indicated that CVID is associated with microbial translocation and systemic myeloid cell activation. The goal of this study was to determine whether patients with CVID display elevated systemic levels of markers of granulocyte activation and whether the levels are further influenced by intravenous immunoglobulin (IVIg) infusions. The plasma levels of granulocyte activation markers elastase and myeloperoxidase were determined using enzyme-linked immunosorbent assay (ELISA) in 46 CVID patients and 44 healthy controls. All CVID patients were in a stable state with no apparent acute infection. In addition, granulocyte activation markers' plasma levels in 24 CVID patients were determined prior to and 1 h following IVIg administration. Neutrophil elastase and myeloperoxidase plasma levels were significantly higher in CVID patients than in healthy controls. Systemic elastase levels were further increased following IVIg administration. In vitro stimulation of 13 CVID patients' whole blood using IVIg in a therapeutically relevant dose for 2 h resulted in a significant increase in plasma elastase levels compared to unstimulated blood. The data presented here indicate that CVID is associated with chronic granulocytic activation which is further exacerbated by administering IVIg. Increased myeloperoxidase and elastase levels may contribute to associated comorbidities in CVID patients.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc19034644
003      
CZ-PrNML
005      
20240909102237.0
007      
ta
008      
191007s2019 enk f 000 0|eng||
009      
AR
024    7_
$a 10.1177/2058738419843381 $2 doi
035    __
$a (PubMed)30968712
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a enk
100    1_
$a Litzman, Jiří $u 1 Department of Clinical Immunology and Allergology, St. Anne's University Hospital, Brno, Czech Republic. 2 Department of Clinicla Immunology and Allergology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
245    10
$a Common variable immunodeficiency patients display elevated plasma levels of granulocyte activation markers elastase and myeloperoxidase / $c J. Litzman, Z. Chovancová, P. Bejdák, M. Litzman, Z. Hel, M. Vlková,
520    9_
$a Common variable immunodeficiency disorders (CVIDs) represent a group of primary immunodeficiency diseases characterized by hypogammaglobulinemia and dysfunctional immune response to invading pathogens. Previous studies have indicated that CVID is associated with microbial translocation and systemic myeloid cell activation. The goal of this study was to determine whether patients with CVID display elevated systemic levels of markers of granulocyte activation and whether the levels are further influenced by intravenous immunoglobulin (IVIg) infusions. The plasma levels of granulocyte activation markers elastase and myeloperoxidase were determined using enzyme-linked immunosorbent assay (ELISA) in 46 CVID patients and 44 healthy controls. All CVID patients were in a stable state with no apparent acute infection. In addition, granulocyte activation markers' plasma levels in 24 CVID patients were determined prior to and 1 h following IVIg administration. Neutrophil elastase and myeloperoxidase plasma levels were significantly higher in CVID patients than in healthy controls. Systemic elastase levels were further increased following IVIg administration. In vitro stimulation of 13 CVID patients' whole blood using IVIg in a therapeutically relevant dose for 2 h resulted in a significant increase in plasma elastase levels compared to unstimulated blood. The data presented here indicate that CVID is associated with chronic granulocytic activation which is further exacerbated by administering IVIg. Increased myeloperoxidase and elastase levels may contribute to associated comorbidities in CVID patients.
650    _2
$a dospělí $7 D000328
650    _2
$a senioři $7 D000368
650    _2
$a senioři nad 80 let $7 D000369
650    _2
$a biologické markery $x krev $7 D015415
650    _2
$a běžná variabilní imunodeficience $x krev $x diagnóza $x farmakoterapie $7 D017074
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a lidé $7 D006801
650    _2
$a intravenózní imunoglobuliny $x aplikace a dávkování $7 D016756
650    _2
$a leukocytární elastasa $x krev $7 D019272
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a lidé středního věku $7 D008875
650    _2
$a peroxidasa $x krev $7 D009195
650    _2
$a mladý dospělý $7 D055815
655    _2
$a časopisecké články $7 D016428
700    1_
$a Chovancová, Zita $u 1 Department of Clinical Immunology and Allergology, St. Anne's University Hospital, Brno, Czech Republic. 2 Department of Clinicla Immunology and Allergology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
700    1_
$a Bejdák, Petr $u 1 Department of Clinical Immunology and Allergology, St. Anne's University Hospital, Brno, Czech Republic. 2 Department of Clinicla Immunology and Allergology, Faculty of Medicine, Masaryk University, Brno, Czech Republic. $7 xx0322341
700    1_
$a Litzman, Marek $u 3 Department of Economics, Faculty of Business and Economics, Mendel University in Brno, Brno, Czech Republic.
700    1_
$a Hel, Zdeněk $u 4 Departments of Pathology and Microbiology, The University of Alabama at Birmingham, Birmingham, AL, USA.
700    1_
$a Vlková, Marcela $u 1 Department of Clinical Immunology and Allergology, St. Anne's University Hospital, Brno, Czech Republic. 2 Department of Clinicla Immunology and Allergology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
773    0_
$w MED00002332 $t International journal of immunopathology and pharmacology $x 2058-7384 $g Roč. 33 (2019), s. 2058738419843381
856    41
$u https://pubmed.ncbi.nlm.nih.gov/30968712 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20191007 $b ABA008
991    __
$a 20240909102235 $b ABA008
999    __
$a ok $b bmc $g 1451304 $s 1073194
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2019 $b 33 $c - $d 2058738419843381 $e - $i 2058-7384 $m International journal of immunopathology and pharmacology $n Int. j. immunopathol. pharmacol. $x MED00002332
GRA    __
$a NV15-28732A $p MZ0
LZP    __
$a Pubmed-20191007
Zpět

Najít záznam

Citační ukazatele

Možnosti archivace