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Automated Family-Wide Annotation of Secondary Structure Elements
A. Midlik, I. Hutařová Vařeková, J. Hutař, TR. Moturu, V. Navrátilová, J. Koča, K. Berka, R. Svobodová Vařeková,
Methods in molecular biology.
2019 ;
1958 (-) :
47-71.
[pub] -
Language English Country United States
Document type Journal Article, Research Support, Non-U.S. Gov't
Persistent link
https://www.medvik.cz/link/bmc19034665
- MeSH
- Algorithms MeSH
- Amino Acid Motifs * MeSH
- Molecular Sequence Annotation methods MeSH
- Catalytic Domain genetics MeSH
- Proteins chemistry genetics MeSH
- Software MeSH
- Computational Biology methods MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
Secondary structure elements (SSEs) are inherent parts of protein structures, and their arrangement is characteristic for each protein family. Therefore, annotation of SSEs can facilitate orientation in the vast number of homologous structures which is now available for many protein families. It also provides a way to identify and annotate the key regions, like active sites and channels, and subsequently answer the key research questions, such as understanding of molecular function and its variability.This chapter introduces the concept of SSE annotation and describes the workflow for obtaining SSE annotation for the members of a selected protein family using program SecStrAnnotator.
References provided by Crossref.org
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