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Fluorine polymer probes for magnetic resonance imaging: quo vadis?
D. Jirak, A. Galisova, K. Kolouchova, D. Babuka, M. Hruby,
Jazyk angličtina Země Německo
Typ dokumentu časopisecké články, přehledy
- MeSH
- fluor chemie MeSH
- fluorokarbony chemie MeSH
- koncentrace vodíkových iontů MeSH
- kontrastní látky chemie MeSH
- lidé MeSH
- molekulární sondy chemie MeSH
- molekulární zobrazování přístrojové vybavení metody MeSH
- myši MeSH
- polymery chemie MeSH
- radiační rozptyl MeSH
- reaktivní formy kyslíku metabolismus MeSH
- světlo MeSH
- teplota MeSH
- zobrazování fluorovou magnetickou rezonancí metody trendy MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- myši MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
Over the last few years, the development and relevance of 19F magnetic resonance imaging (MRI) for use in clinical practice has emerged. MRI using fluorinated probes enables the achievement of a specific signal with high contrast in MRI images. However, to ensure sufficient sensitivity of 19F MRI, fluorine probes with a high content of chemically equivalent fluorine atoms are required. The majority of 19F MRI agents are perfluorocarbon emulsions, which have a broad range of applications in molecular imaging, although the content of fluorine atoms in these molecules is limited. In this review, we focus mainly on polymer probes that allow higher fluorine content and represent versatile platforms with properties tailorable to a plethora of biomedical in vivo applications. We discuss the chemical development, up to the first imaging applications, of these promising fluorine probes, including injectable polymers that form depots that are intended for possible use in cancer therapy.
Citace poskytuje Crossref.org
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- $a Jirak, Daniel $u Institute for Clinical and Experimental Medicine, Vídeňská 9, 140 21, Prague 4, Czech Republic. daniel.jirak@ikem.cz. Institute of Biophysics and Informatics, 1st Medicine Faculty, Charles University, Salmovská 1, 120 00, Prague, Czech Republic. daniel.jirak@ikem.cz. Faculty of Health Studies, Technical University of Liberec, Studentská 1402/2, 461 17, Liberec 1, Czech Republic. daniel.jirak@ikem.cz.
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- $a Fluorine polymer probes for magnetic resonance imaging: quo vadis? / $c D. Jirak, A. Galisova, K. Kolouchova, D. Babuka, M. Hruby,
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- $a Over the last few years, the development and relevance of 19F magnetic resonance imaging (MRI) for use in clinical practice has emerged. MRI using fluorinated probes enables the achievement of a specific signal with high contrast in MRI images. However, to ensure sufficient sensitivity of 19F MRI, fluorine probes with a high content of chemically equivalent fluorine atoms are required. The majority of 19F MRI agents are perfluorocarbon emulsions, which have a broad range of applications in molecular imaging, although the content of fluorine atoms in these molecules is limited. In this review, we focus mainly on polymer probes that allow higher fluorine content and represent versatile platforms with properties tailorable to a plethora of biomedical in vivo applications. We discuss the chemical development, up to the first imaging applications, of these promising fluorine probes, including injectable polymers that form depots that are intended for possible use in cancer therapy.
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